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Agonist activity at AhR in mouse Hepa2Dluc cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]TCDD from mouse AhR expressed in mouse Hepa1c1c7 cells cytosol incubated for 2 hrs by competitive radioligand binding assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Activation of AhR in mouse Hepa1c1c7 cells assessed as induction of XRE-dependent reporter activity incubated for 4 hrs by Renilla/Firefly based dual-luciferase reporter assay
Activation of AhR in mouse NIH3T3 cells assessed as induction of XRE-dependent reporter activity incubated for 4 hrs by Renilla/Firefly based dual-luciferase reporter assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Activation of AhR in purmorphamine-treated mouse C3H 10T1/2 cells assessed as upregulation of Cyp1B1 mRNA levels measured after 96 hrs by RT-qPCR analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of AhR in purmorphamine-treated mouse C3H 10T1/2 cells assessed as translocation of AhR from cytoplasm to nucleus at 1 nM incubated for 24 hrs by immunostaining based analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding Assay from Article : "Photoaffinity labeling of the Ah receptor."
Assay data:8 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Displacement of 2-azido-3-[125I]7,8-dibromodibenzo-pdioxin from C57BL/6J mouse liver AhR relative to TCDD
Displacement of [3H]TCDD from mouse AhR
Displacement of 2-azido-3-[125I]7,8-dibromodibenzo-pdioxin from C57BL/6J mouse liver AhR incubated for 20 mins by gamma counting based autoradiography
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of 2-azido-3-[125I]7,8-dibromodibenzo-pdioxin from C57BL/6J mouse liver AhR
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Agonist activity at AHR in FVB/N mouse primary mammary epithelial cells assessed as upregulation of desmoglein-3 protein level at 10 uM after 144 hrs by Western blot analysis in presence of FGF2
Assay data:4 Active, 6 Tested
Agonist activity at AHR in FVB/N mouse primary mammary epithelial cells assessed as upregulation of desmoglein-3 protein level at 10 nM after 144 hrs by Western blot analysis in presence of FGF2
Agonist activity at AHR in FVB/N mouse primary mammary epithelial cells assessed as blockade of mammary branching morphogenesis after 144 hrs by microscopic analysis in presence of FGF2
Assay data:4 Active, 5 Tested
Agonist activity at AHR in mouse HC11 cells assessed as upregulation of Cyp1a1 gene expression at 10 uM after 48 hrs by RT-PCR analysis relative to control
Assay data:25 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Agonist activity at Ah receptor in genetically engineered mouse cells expressing firefly luciferase gene by CALUX transactivational assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 5 Tested
Induction of Ah receptor in mouse Hepa-1c1c7 cells assessed as induction of CYP1A1 activity at 1 uM after 48 hrs by EROD assay relative to control
Assay data:3 Tested
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