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KAT-5 Enzyme Assay from US Patent US11685732: "MYST family histone acetyltransferase inhibitors"
Assay data:270 Active, 436 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Kat5 Assay from US Patent US11492346: "Benzisoxazole sulfonamide derivatives"
Assay data:43 Active, 24 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of KAT5 (unknown origin) using Histone H2A substrate at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity interaction (HAT panel) EUB0000329a KAT5
SummaryRelated BioAssays by Target
Inhibition of GST tagged human TIP60 expressed in Sf9 cells using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay
Assay data:2 Tested
Inhibition of TIP60 (unknown origin)
TIP60 (HAT) CEREP ligand profiling
Inhibition of KAT5 (unknown origin)
Displacement of [3H]-acetyl-CoA from recombinant Tip60 (unknown origin) at 150 uM using H4-20 as substrate after 5 mins by scintillation counting analysis relative to control
Inhibition of Tip60 (unknown origin) using [3H]-acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Tip60 (unknown origin)
Displacement of [3H]-acetyl-CoA from recombinant Tip60 (unknown origin) by scintillation counting analysis
Inhibition of Tip60 (unknown origin) at 500 uM relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human lysine acetyltransferase 5 (2.3.1.48 Histone acetyltransferases (HATs))
Inhibition of recombinant human GFP-tagged TIP60 expressed in chicken embryo DT40 cells using histone substrate at 500 uM incubated for 1 hr followed by ionizing radiation treatment by immunosorbent gel assay relative to control
Inhibition of recombinant N-terminal His-tagged TIP60 (unknown origin) expressed in baculovirus-infected insect cell system using histone substrate incubated for 10 mins by radiometric filter binding assay in presence of [3H]acetyl-CoA
Inhibition of full length TIP60 (unknown origin) expressed in Escherichia coli using N-terminal histone H4-20 peptide substrate incubated for 10 mins by liquid scintillation counting method in presence of [3H]acetyl-CoA
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