Entry - *619021 - ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 37; ANKRD37 - OMIM

 
 
* 619021

ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 37; ANKRD37


HGNC Approved Gene Symbol: ANKRD37

Cytogenetic location: 4q35.1     Genomic coordinates (GRCh38): 4:185,396,841-185,400,723 (from NCBI)


TEXT

▼ Description

ANKRD37 contains 4 ankyrin (see 612641) repeat domains, which are typically involved in protein-protein interactions and in signaling pathways (Li et al., 2005).


▼ Cloning and Expression

Li et al. (2005) cloned ANKRD37, which they called LRP2BP, from a human fetal brain cDNA library. The deduced 158-amino acid protein has a calculated molecular mass of 16.9 kD and contains 4 ankyrin repeat domains and 5 phosphorylation sites. RT-PCR detected LRP2BP expression mainly in human testis, small intestine, colon, and blood leukocytes. Epitope-tagged LRP2BP localized to both cytoplasm and nucleus of transfected HEK293 cells. ANKRD37 orthologs were identified in chimpanzee, mouse, rat, and frog.


▼ Gene Structure

Li et al. (2005) determined that the ANKRD37 gene contains 5 exons and spans 3.5 kb.


▼ Mapping

By genomic sequence analysis, Li et al. (2005) mapped the LRP2BP gene to chromosome 4q35.


▼ Nomenclature

Although Li et al. (2005) referred to ANKRD37 as LRP2BP, ANKRD37 is distinct from the LRP2BP gene (619020).


▼ REFERENCES

  1. Li, J., Ji, C., Zheng, H., Fei, X., Zheng, M., Dai, J., Gu, S., Xie, Y., Mao, Y. Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains. Cell. Molec. Biol. Lett. 10: 185-193, 2005. [PubMed: 15809689, related citations]


Contributors:
Matthew B. Gross - updated : 09/11/2020
Creation Date:
Bao Lige : 09/11/2020
Edit History:
mgross : 09/11/2020

* 619021

ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 37; ANKRD37


HGNC Approved Gene Symbol: ANKRD37

Cytogenetic location: 4q35.1     Genomic coordinates (GRCh38): 4:185,396,841-185,400,723 (from NCBI)


TEXT

Description

ANKRD37 contains 4 ankyrin (see 612641) repeat domains, which are typically involved in protein-protein interactions and in signaling pathways (Li et al., 2005).


Cloning and Expression

Li et al. (2005) cloned ANKRD37, which they called LRP2BP, from a human fetal brain cDNA library. The deduced 158-amino acid protein has a calculated molecular mass of 16.9 kD and contains 4 ankyrin repeat domains and 5 phosphorylation sites. RT-PCR detected LRP2BP expression mainly in human testis, small intestine, colon, and blood leukocytes. Epitope-tagged LRP2BP localized to both cytoplasm and nucleus of transfected HEK293 cells. ANKRD37 orthologs were identified in chimpanzee, mouse, rat, and frog.


Gene Structure

Li et al. (2005) determined that the ANKRD37 gene contains 5 exons and spans 3.5 kb.


Mapping

By genomic sequence analysis, Li et al. (2005) mapped the LRP2BP gene to chromosome 4q35.


Nomenclature

Although Li et al. (2005) referred to ANKRD37 as LRP2BP, ANKRD37 is distinct from the LRP2BP gene (619020).


REFERENCES

  1. Li, J., Ji, C., Zheng, H., Fei, X., Zheng, M., Dai, J., Gu, S., Xie, Y., Mao, Y. Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains. Cell. Molec. Biol. Lett. 10: 185-193, 2005. [PubMed: 15809689]


Contributors:
Matthew B. Gross - updated : 09/11/2020

Creation Date:
Bao Lige : 09/11/2020

Edit History:
mgross : 09/11/2020



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 5, 2024