Alternative titles; symbols
HGNC Approved Gene Symbol: OR1A2
Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:3,197,519-3,198,448 (from NCBI)
OR1A2 is 1 of several olfactory receptor superfamily genes clustered on chromosome 17p13.3. OR1A2 is a duplicated paralog of OR1A1 (618046) (Glusman et al., 2000).
By sequence analysis, Glusman et al. (2000) identified OR1A2 within an olfactory receptor gene cluster on chromosome 17.
By RT-PCR of human olfactory epithelium biopsy material, Schmiedeberg et al. (2007) identified OR1A2 and its paralog, OR1A1. Both OR1A1 and OR1A2 have 7 transmembrane domains with an extracellular N terminus and an intracellular C terminus. OR1A1 and OR1A2 are the closest human homologs to the mouse olfactory receptors Olfr43 and Olfr403.
Schmiedeberg et al. (2007) found that human OR1A1 and OR1A2 had odorant profiles similar to that of mouse Olfr43, centering around citronellic terpenoid structures with similar efficacies. Two evolutionary conserved amino acids corresponding to positions 121 and 122 in transmembrane domain 3 in human OR1A1 and mouse Olfr43 conferred similar responsiveness towards (S)-(-)-citronellol. Changes at these 2 residues determined the differential (S)-(-)-citronellol responsiveness between human OR1A1 and OR1A2. Structural analysis showed that the interaction sites for (S)-(-)-citronellol and (S)-(-)-citronellal differed in the 2 human receptors.
Glusman et al. (2000) reported that the OR1A2 gene contains 1 upstream noncoding exon that shares sequence similarity with an upstream noncoding exon of the OR1A1 gene.
By genomic sequence analysis, Glusman et al. (2000) mapped the OR1A2 gene within an olfactory receptor gene cluster on chromosome 17p13.3.
Glusman et al. (2000) determined that sequence expansion by repeated retroposition invasion about 58 to 65 million years ago produced 2 duplicated, functional genes: OR1A1 and OR1A2.
Glusman, G., Sosinsky, A., Ben-Asher, E., Avidan, N., Sonkin, D., Bahar, A., Rosenthal, A., Clifton, S., Roe, B., Ferraz, C., Demaille, J., Lancet, D. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. Genomics 63: 227-245, 2000. [PubMed: 10673334] [Full Text: https://doi.org/10.1006/geno.1999.6030]
Schmiedeberg, K., Shirokova, E., Weber, H.-P., Schilling, B., Meyerhof, W., Krautwurst, D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J. Struct. Biol. 159: 400-412, 2007. [PubMed: 17601748] [Full Text: https://doi.org/10.1016/j.jsb.2007.04.013]