Entry - *613996 - NEUROBLASTOMA BREAKPOINT FAMILY, MEMBER 6; NBPF6 - OMIM

 
 
* 613996

NEUROBLASTOMA BREAKPOINT FAMILY, MEMBER 6; NBPF6


HGNC Approved Gene Symbol: NBPF6

Cytogenetic location: 1p13.3     Genomic coordinates (GRCh38): 1:108,421,491-108,471,920 (from NCBI)


TEXT

▼ Description

NBPF6 is a member of the NBPF gene family, which consists of 22 genes and pseudogenes that arose by gene duplication. NBPF genes contain numerous low-copy repetitive elements and show high intergenic and intragenic sequence identity in coding and noncoding regions (Vandepoele et al., 2005).


▼ Cloning and Expression

By searching an EST database for sequences similar to NBPF1 (610501), Vandepoele et al. (2005) identified NBPF6.


▼ Gene Structure

Vandepoele et al. (2005) determined that the NBPF6 gene contains 14 coding exons, 1 of which results from an internal duplication. NBPF6 lacks a LINE repeat insert present in other NBPF genes.


▼ Mapping

By genomic sequence analysis and FISH, Vandepoele et al. (2005) mapped the NBPF6 gene to an NBPF gene cluster on chromosome 1p12.


▼ REFERENCES

  1. Vandepoele, K., Van Roy, N., Staes, K., Speleman, F., van Roy, F. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. Molec. Biol. Evol. 22: 2265-2274, 2005. [PubMed: 16079250, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 5/24/2011
Edit History:
mgross : 05/25/2011
mgross : 5/24/2011

* 613996

NEUROBLASTOMA BREAKPOINT FAMILY, MEMBER 6; NBPF6


HGNC Approved Gene Symbol: NBPF6

Cytogenetic location: 1p13.3     Genomic coordinates (GRCh38): 1:108,421,491-108,471,920 (from NCBI)


TEXT

Description

NBPF6 is a member of the NBPF gene family, which consists of 22 genes and pseudogenes that arose by gene duplication. NBPF genes contain numerous low-copy repetitive elements and show high intergenic and intragenic sequence identity in coding and noncoding regions (Vandepoele et al., 2005).


Cloning and Expression

By searching an EST database for sequences similar to NBPF1 (610501), Vandepoele et al. (2005) identified NBPF6.


Gene Structure

Vandepoele et al. (2005) determined that the NBPF6 gene contains 14 coding exons, 1 of which results from an internal duplication. NBPF6 lacks a LINE repeat insert present in other NBPF genes.


Mapping

By genomic sequence analysis and FISH, Vandepoele et al. (2005) mapped the NBPF6 gene to an NBPF gene cluster on chromosome 1p12.


REFERENCES

  1. Vandepoele, K., Van Roy, N., Staes, K., Speleman, F., van Roy, F. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. Molec. Biol. Evol. 22: 2265-2274, 2005. [PubMed: 16079250] [Full Text: https://doi.org/10.1093/molbev/msi222]


Creation Date:
Patricia A. Hartz : 5/24/2011

Edit History:
mgross : 05/25/2011
mgross : 5/24/2011



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 4, 2024