Alternative titles; symbols
HGNC Approved Gene Symbol: LCE3E
Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,565,654-152,566,780 (from NCBI)
For background information on the LCE gene cluster, see 612603.
By database analysis to identify human orthologs of mouse genes encoding late envelope proteins (LEPs), Marshall et al. (2001) identified LCE3E, which they called LEP17. RT-PCR detected LEP17 in human skin, esophagus, and heart.
Using real-time PCR, Jackson et al. (2005) detected very low LCE3E expression in adult and fetal skin. Low LCE3E expression was also detected in internal epithelia, including vulva, tongue, and esophagus.
Jackson et al. (2005) showed that expression of LCE3E was upregulated in cultured normal human keratinocytes by ultraviolet radiation. At 48 hours after irradiation, the level of LCE3E was upregulated over 350-fold compared with mock-irradiated controls. LCE3E expression was not regulated by calcium.
Jackson et al. (2005) determined that LCE3E is a single-exon gene.
By genomic sequence analysis, Marshall et al. (2001) mapped the LCE3E gene within the LCE gene cluster on chromosome 1q21. Jackson et al. (2005) determined that the LCE3E gene lies within intron 1 of the LCE3C gene (612615) and is oriented in the opposite direction. They stated that the mouse Lce3e gene maps to a syntenic LCE gene cluster on chromosome 3F1.
Jackson, B., Tilli, C. M. L. J., Hardman, M. J., Avilion, A. A., MacLeod, M. C., Ashcroft, G. S., Byrne, C. Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation. J. Invest. Derm. 124: 1062-1070, 2005. [PubMed: 15854049] [Full Text: https://doi.org/10.1111/j.0022-202X.2005.23699.x]
Marshall, D., Hardman, M. J., Nield, K. M., Byrne, C. Differentially expressed late constituents of the epidermal cornified envelope. Proc. Nat. Acad. Sci. 98: 13031-13036, 2001. [PubMed: 11698679] [Full Text: https://doi.org/10.1073/pnas.231489198]