Alternative titles; symbols
HGNC Approved Gene Symbol: RIMS3
Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,620,680-40,692,066 (from NCBI)
By sequencing clones obtained from a human immature myeloid cell line cDNA library, Nagase et al. (1996) cloned RIMS3, which they designated KIAA0237. The deduced 308-amino acid protein has a glycosyl hydrolase motif. Northern blot analysis detected RIMS3 expression in all tissues examined, with highest expression in brain.
Wang et al. (2000) cloned rat Rims3, which they called Nim3, and identified human RIMS3 by database analysis. The deduced protein contains a C2B domain and is highly homologous to the C-terminal parts of RIMS1 and RIMS2, but it lacks all of the N-terminal domains of RIMS1 and RIMS2. Northern blot analysis of rat tissues detected Rims3 expression in brain only.
Wang et al. (2000) found that rat Nim3 enhanced Ca(2+)-dependent secretion from transfected rat pheochromocytoma cells.
Wang and Sudhof (2003) determined that the RIMS3 gene contains 6 exons and spans 15.4 kb.
Using radiation hybrid analysis, Nagase et al. (1996) mapped the RIMS3 gene to chromosome 1. By genomic sequence analysis, Wang and Sudhof (2003) mapped the RIMS3 gene to human chromosome 1p34.1 and to mouse chromosome 4D2.2.
Nagase, T., Seki, N., Ishikawa, K., Ohira, M., Kawarabayasi, Y., Ohara, O., Tanaka, A., Kotani, H., Miyajima, N., Nomura, N. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. DNA Res. 3: 321-329, 1996. [PubMed: 9039502] [Full Text: https://doi.org/10.1093/dnares/3.5.321]
Wang, Y., Sudhof, T. C. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. Genomics 81: 126-137, 2003. [PubMed: 12620390] [Full Text: https://doi.org/10.1016/s0888-7543(02)00024-1]
Wang, Y., Sugita, S., Sudhof, T. C. The RIM/NIM family of neuronal C2 domain proteins: interactions with Rab3 and a new class of Src homology 3 domain proteins. J. Biol. Chem. 275: 20033-20044, 2000. [PubMed: 10748113] [Full Text: https://doi.org/10.1074/jbc.M909008199]