Entry - *611001 - MYST/ESA1-ASSOCIATED FACTOR 6; MEAF6 - OMIM

 
 
* 611001

MYST/ESA1-ASSOCIATED FACTOR 6; MEAF6


Alternative titles; symbols

EAF6, S. CEREVISIAE, HOMOLOG OF; EAF6
CHROMOSOME 1 OPEN READING FRAME 149; C1ORF149


HGNC Approved Gene Symbol: MEAF6

Cytogenetic location: 1p34.3     Genomic coordinates (GRCh38): 1:37,489,993-37,514,766 (from NCBI)


TEXT

▼ Cloning and Expression

The NuA4 histone acetyltransferase (HAT) complex is responsible for acetylation of the N-terminal tails of histone H4 (see 602822) and H2A (see 613499) in yeast. Its catalytic subunit, Esa1, is homologous to human TIP60 (HTATIP; 601409). Using affinity purification, Western blot analysis, cell fractionation, immunoprecipitation, and mass spectrometry, Doyon et al. (2004) found that TIP60 and its splice variant, TIP60B/PLIP, were part of a multisubunit NuA4 complex with HAT activity in several human cell lines. They identified human homologs for 11 of the 12 yeast NuA4 subunits, including EAF6. The EAF6 protein contains 201 amino acids.


▼ Mapping

The International Radiation Hybrid Mapping Consortium mapped the C1ORF149 gene (MEAF6) to chromosome 1 (RH79090).

▼ REFERENCES

  1. Doyon, Y., Selleck, W., Lane, W. S., Tan, S., Cote, J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Molec. Cell. Biol. 24: 1884-1896, 2004. [PubMed: 14966270, images, related citations] [Full Text]


Creation Date:
Matthew B. Gross : 5/8/2007
Edit History:
alopez : 12/10/2014
mgross : 2/8/2013
mgross : 1/11/2013
wwang : 5/8/2007
mgross : 5/8/2007

* 611001

MYST/ESA1-ASSOCIATED FACTOR 6; MEAF6


Alternative titles; symbols

EAF6, S. CEREVISIAE, HOMOLOG OF; EAF6
CHROMOSOME 1 OPEN READING FRAME 149; C1ORF149


HGNC Approved Gene Symbol: MEAF6

Cytogenetic location: 1p34.3     Genomic coordinates (GRCh38): 1:37,489,993-37,514,766 (from NCBI)


TEXT

Cloning and Expression

The NuA4 histone acetyltransferase (HAT) complex is responsible for acetylation of the N-terminal tails of histone H4 (see 602822) and H2A (see 613499) in yeast. Its catalytic subunit, Esa1, is homologous to human TIP60 (HTATIP; 601409). Using affinity purification, Western blot analysis, cell fractionation, immunoprecipitation, and mass spectrometry, Doyon et al. (2004) found that TIP60 and its splice variant, TIP60B/PLIP, were part of a multisubunit NuA4 complex with HAT activity in several human cell lines. They identified human homologs for 11 of the 12 yeast NuA4 subunits, including EAF6. The EAF6 protein contains 201 amino acids.


Mapping

The International Radiation Hybrid Mapping Consortium mapped the C1ORF149 gene (MEAF6) to chromosome 1 (RH79090).

REFERENCES

  1. Doyon, Y., Selleck, W., Lane, W. S., Tan, S., Cote, J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Molec. Cell. Biol. 24: 1884-1896, 2004. [PubMed: 14966270] [Full Text: https://doi.org/10.1128/MCB.24.5.1884-1896.2004]


Creation Date:
Matthew B. Gross : 5/8/2007

Edit History:
alopez : 12/10/2014
mgross : 2/8/2013
mgross : 1/11/2013
wwang : 5/8/2007
mgross : 5/8/2007



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 31, 2024