Entry - *609045 - G PROTEIN-COUPLED RECEPTOR 141; GPR141 - OMIM

 
 
* 609045

G PROTEIN-COUPLED RECEPTOR 141; GPR141


Alternative titles; symbols

PGR13


HGNC Approved Gene Symbol: GPR141

Cytogenetic location: 7p14.1     Genomic coordinates (GRCh38): 7:37,683,766-37,743,835 (from NCBI)


TEXT

▼ Description

GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).


▼ Cloning and Expression

By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR141. The deduced 299-amino acid protein assumes a classic 7-transmembrane (TM) topology. Instead of the DRY motif in the intracellular side of TM3, GPR141 has a TRY motif, and it has no classic NSxxNPxxY motif in TM7. GPR141 shares 67% amino acid identity with mouse Gpr141. EST database analysis indicated that GPR141 is expressed in bone marrow.


▼ Gene Structure

Fredriksson et al. (2003) determined that the mouse and human GPR141 genes contain a single coding exon.


▼ Mapping

By genomic sequence analysis, Fredriksson et al. (2003) mapped the GPR141 gene to chromosome 7p14.1. They mapped the mouse Gpr141 gene to chromosome 13.


▼ REFERENCES

  1. Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed: 14623098, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 11/23/2004
Edit History:
mgross : 11/23/2004

* 609045

G PROTEIN-COUPLED RECEPTOR 141; GPR141


Alternative titles; symbols

PGR13


HGNC Approved Gene Symbol: GPR141

Cytogenetic location: 7p14.1     Genomic coordinates (GRCh38): 7:37,683,766-37,743,835 (from NCBI)


TEXT

Description

GPR141 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).


Cloning and Expression

By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR141. The deduced 299-amino acid protein assumes a classic 7-transmembrane (TM) topology. Instead of the DRY motif in the intracellular side of TM3, GPR141 has a TRY motif, and it has no classic NSxxNPxxY motif in TM7. GPR141 shares 67% amino acid identity with mouse Gpr141. EST database analysis indicated that GPR141 is expressed in bone marrow.


Gene Structure

Fredriksson et al. (2003) determined that the mouse and human GPR141 genes contain a single coding exon.


Mapping

By genomic sequence analysis, Fredriksson et al. (2003) mapped the GPR141 gene to chromosome 7p14.1. They mapped the mouse Gpr141 gene to chromosome 13.


REFERENCES

  1. Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed: 14623098] [Full Text: https://doi.org/10.1016/s0014-5793(03)01196-7]


Creation Date:
Patricia A. Hartz : 11/23/2004

Edit History:
mgross : 11/23/2004



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 2, 2024