Entry - *609043 - RELAXIN/INSULIN-LIKE FAMILY PEPTIDE RECEPTOR 4; RXFP4 - OMIM

 
 
* 609043

RELAXIN/INSULIN-LIKE FAMILY PEPTIDE RECEPTOR 4; RXFP4


Alternative titles; symbols

RELAXIN 3 RECEPTOR 2; RLN3R2
RLN3 RECEPTOR 2
G PROTEIN-COUPLED RECEPTOR 100; GPR100
G PROTEIN-COUPLED RECEPTOR 142; GPCR142


HGNC Approved Gene Symbol: RXFP4

Cytogenetic location: 1q22     Genomic coordinates (GRCh38): 1:155,941,638-155,943,087 (from NCBI)


TEXT

▼ Description

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).


▼ Cloning and Expression

By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR100. The deduced 374-amino acid protein assumes a classic 7-transmembrane (TM) topology and contains an NSxxNPxxY motif in TM7. In place of the DRY motif in the intracellular side of TM3, GPR100 contains an ARY motif. GPR100 shares 78% amino acid identity with mouse Gpr100. The TM domains of mouse and human GPR100 are nearly 100% conserved, with most differences in the N and C termini. EST database analysis indicated that GPR100 is expressed in bone marrow.


▼ Gene Structure

Fredriksson et al. (2003) determined that the mouse and human GPR120 genes contain a single coding exon.


▼ Mapping

By genomic sequence analysis, Fredriksson et al. (2003) mapped the GPR100 gene to chromosome 1q22. They mapped the mouse Gpr100 gene to chromosome 3.


▼ REFERENCES

  1. Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed: 14623098, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 11/23/2004
Edit History:
carol : 05/30/2017
mgross : 06/27/2005
mgross : 11/23/2004

* 609043

RELAXIN/INSULIN-LIKE FAMILY PEPTIDE RECEPTOR 4; RXFP4


Alternative titles; symbols

RELAXIN 3 RECEPTOR 2; RLN3R2
RLN3 RECEPTOR 2
G PROTEIN-COUPLED RECEPTOR 100; GPR100
G PROTEIN-COUPLED RECEPTOR 142; GPCR142


HGNC Approved Gene Symbol: RXFP4

Cytogenetic location: 1q22     Genomic coordinates (GRCh38): 1:155,941,638-155,943,087 (from NCBI)


TEXT

Description

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003).


Cloning and Expression

By searching databases for sequences similar to rhodopsin-like GPRs, Fredriksson et al. (2003) identified GPR100. The deduced 374-amino acid protein assumes a classic 7-transmembrane (TM) topology and contains an NSxxNPxxY motif in TM7. In place of the DRY motif in the intracellular side of TM3, GPR100 contains an ARY motif. GPR100 shares 78% amino acid identity with mouse Gpr100. The TM domains of mouse and human GPR100 are nearly 100% conserved, with most differences in the N and C termini. EST database analysis indicated that GPR100 is expressed in bone marrow.


Gene Structure

Fredriksson et al. (2003) determined that the mouse and human GPR120 genes contain a single coding exon.


Mapping

By genomic sequence analysis, Fredriksson et al. (2003) mapped the GPR100 gene to chromosome 1q22. They mapped the mouse Gpr100 gene to chromosome 3.


REFERENCES

  1. Fredriksson, R., Hoglund, P. J., Gloriam, D. E. I., Lagerstrom, M. C., Schioth, H. B. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 554: 381-388, 2003. [PubMed: 14623098] [Full Text: https://doi.org/10.1016/s0014-5793(03)01196-7]


Creation Date:
Patricia A. Hartz : 11/23/2004

Edit History:
carol : 05/30/2017
mgross : 06/27/2005
mgross : 11/23/2004



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 2, 2024