Alternative titles; symbols
HGNC Approved Gene Symbol: PCDHB5
Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,135,206-141,138,615 (from NCBI)
Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of nonclassic cadherins. PCDHB5 is 1 of 16 tandemly arranged genes in the PCDHB gene cluster (604967) on chromosome 5q31. Unlike the PCDHA (see 604966) and PCDHG (see 604968) genes, which function as 'variable' exons that are spliced to downstream constant region exons to produce mRNAs, the PCDHB genes do not use constant region exons to produce mRNAs. Thus, each single-exon PCDHB gene encodes the extracellular, transmembrane, and short cytoplasmic domains of the protein (Wu et al., 2001). For further information on the PCDHB genes, see 604967.
By PCR of a brain cDNA library, Wu and Maniatis (1999) cloned full-length PCDHB5.
Wu et al. (2001) determined that human PCDHB5 is most paralogous to 6 mouse PCDHB genes, Pcdhb4, Pcdhb6, Pcdhb8, Pcdhb10, Pcdhb11, and Pcdhb12.
By genomic sequence analysis, Wu et al. (2001) mapped the PCDHB5 gene to chromosome 5q31. They localized the mouse PCDHB genes to chromosome 18c.
Wu, Q., Maniatis, T. A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 97: 779-790, 1999. [PubMed: 10380929] [Full Text: https://doi.org/10.1016/s0092-8674(00)80789-8]
Wu, Q., Zhang, T., Cheng, J.-F., Kim, Y., Grimwood, J., Schmutz, J., Dickson, M., Noonan, J. P., Zhang, M. Q., Myers, R. M., Maniatis, T. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Res. 11: 389-404, 2001. [PubMed: 11230163] [Full Text: https://doi.org/10.1101/gr.167301]