Alternative titles; symbols
HGNC Approved Gene Symbol: DNAJC4
Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,230,432-64,234,281 (from NCBI)
The E. coli heat-shock protein DnaJ is the founding member of a family of proteins that are associated with protein folding, complex assembly, and export. Prokaryotic and eukaryotic DnaJ homologs contain an approximately 70-amino acid J domain, which is thought to mediate interaction with 70-kD heat-shock proteins (e.g., 603012). During sequence characterization of the VEGFB (601398) promoter region in 11q13, Silins et al. (1997) identified an EST corresponding to the 3-prime untranslated region of a novel gene, HSPF2, which they named MCG18 for 'multiple endocrine neoplasia type 1 candidate gene-18.' Silins et al. (1998) sequenced the HSPF2 gene from a cosmid and identified additional HSPF2 ESTs. The HSPF2 gene is located approximately 250 bp centromeric of the VEGFB gene. The HSPF2 coding sequence is contained in 5 exons. The deduced 241-amino acid HSPF2 protein has a J domain followed by a predicted transmembrane domain. The human and mouse HSPF2 proteins are 71% identical. Northern blot analysis detected an approximately 1.4-kb HSPF2 transcript in all human cell lines examined.
Silins et al. (1997) identified the DNAJC4 gene on chromosome 11q13.
Silins, G., Grimmond, S., Egerton, M., Hayward, N. Analysis of the promoter region of the human VEGF-related factor gene. Biochem. Biophys. Res. Commun. 230: 413-418, 1997. [PubMed: 9016794] [Full Text: https://doi.org/10.1006/bbrc.1996.5979]
Silins, G., Grimmond, S., Hayward, N. Characterisation of a new human and murine member of the DnaJ family of proteins. Biochem. Biophys. Res. Commun. 243: 273-276, 1998. [PubMed: 9473517] [Full Text: https://doi.org/10.1006/bbrc.1997.8091]