Alternative titles; symbols
HGNC Approved Gene Symbol: BMX
Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,500,807-15,556,519 (from NCBI)
Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC (600583), TXK (600058), ITK (186973), and BTK (300300). All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.
Tamagnone et al. (1994) reported the cloning of a human cDNA for a nonreceptor tyrosine kinase gene, which they designated BMX. The BMX cDNA was cloned by degenerate PCR and screening of a human bone marrow cDNA library and has an open reading frame of 675 amino acids. BMX and the other members of this superfamily each contain a so-called pleckstrin homology domain. By Northern blot analysis, Tamagnone et al. (1994) showed that BMX is transcribed in bone marrow as well as endothelial cells, and by Western blot analysis they detected an 80-kD protein corresponding to BMX in human endothelial cells. A similar size protein was identified in COS cells transfected with a BMX expression vector.
Tamagnone et al. (1994) concluded that BMX may play a role in the growth and differentiation of hematopoietic cells.
Tamagnone et al. (1994) mapped the BMX gene to Xp22.2 by fluorescence in situ hybridization.
Rajantie et al. (2001) studied the expression of Bmx in mice carrying an inactive Bmx-lacZ fusion gene. Expression was found in the endothelial cells of large arteries and in the endocardium starting between days 10.5 and 12.5 of embryogenesis and continuing in adult mice. Venular endothelium showed only a weak signal. Rajantie et al. (2001) noted no obvious phenotype with loss of Bmx function, suggesting that Bmx tyrosine kinase has a redundant role in arterial endothelial signal transduction.
Rajantie, I., Ekman, N., Iljin, K., Arighi, E., Gunji, Y., Kaukonen, J., Palotie, A., Dewerchin, M., Carmeliet, P., Alitalo, K. Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Molec. Cell. Biol. 21: 4647-4655, 2001. [PubMed: 11416142] [Full Text: https://doi.org/10.1128/MCB.21.14.4647-4655.2001]
Tamagnone, L., Lahtinen, I., Mustonen, T., Virtaneva, K., Francis, F., Muscatelli, F., Alitalo, R., Edvard Smith, C. I., Larsson, C., Alitalo, K. BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. Oncogene 9: 3683-3688, 1994. [PubMed: 7970727]