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OBESITY (BMIQ9), SUSCEPTIBILITY TO(BMIQ9)

MedGen UID:
393673
•Concept ID:
C2677162
•
Finding
Synonyms: BMIQ9; Body mass index quantitative trait locus 9; Obesity, Susceptibility to, MC3R-Related
 
Gene (location): MC3R (20q13.2)
 
OMIM®: 602025

Recent clinical studies

Etiology

Genetics of Obesity: What We Have Learned Over Decades of Research.
Bouchard C
Obesity (Silver Spring) 2021 May;29(5):802-820. doi: 10.1002/oby.23116. PMID: 33899337
The hematologic consequences of obesity.
Purdy JC, Shatzel JJ
Eur J Haematol 2021 Mar;106(3):306-319. Epub 2020 Dec 13 doi: 10.1111/ejh.13560. PMID: 33270290Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Obesity and female infertility: potential mediators of obesity's impact.
Broughton DE, Moley KH
Fertil Steril 2017 Apr;107(4):840-847. Epub 2017 Mar 11 doi: 10.1016/j.fertnstert.2017.01.017. PMID: 28292619
Physical activity and obesity in children.
Hills AP, Andersen LB, Byrne NM
Br J Sports Med 2011 Sep;45(11):866-70. doi: 10.1136/bjsports-2011-090199. PMID: 21836171

Diagnosis

Current Treatments for Patients with Genetic Obesity.
Faccioli N, Poitou C, Clément K, Dubern B
J Clin Res Pediatr Endocrinol 2023 May 29;15(2):108-119. Epub 2023 May 16 doi: 10.4274/jcrpe.galenos.2023.2023-3-2. PMID: 37191347Free PMC Article
Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity.
Tilg H, Adolph TE, Dudek M, Knolle P
Nat Metab 2021 Dec;3(12):1596-1607. Epub 2021 Dec 20 doi: 10.1038/s42255-021-00501-9. PMID: 34931080
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Stress and Obesity: Are There More Susceptible Individuals?
van der Valk ES, Savas M, van Rossum EFC
Curr Obes Rep 2018 Jun;7(2):193-203. doi: 10.1007/s13679-018-0306-y. PMID: 29663153Free PMC Article

Therapy

Current Treatments for Patients with Genetic Obesity.
Faccioli N, Poitou C, Clément K, Dubern B
J Clin Res Pediatr Endocrinol 2023 May 29;15(2):108-119. Epub 2023 May 16 doi: 10.4274/jcrpe.galenos.2023.2023-3-2. PMID: 37191347Free PMC Article
Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome.
Green M, Arora K, Prakash S
Int J Mol Sci 2020 Apr 21;21(8) doi: 10.3390/ijms21082890. PMID: 32326175Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716
Obesity and female infertility: potential mediators of obesity's impact.
Broughton DE, Moley KH
Fertil Steril 2017 Apr;107(4):840-847. Epub 2017 Mar 11 doi: 10.1016/j.fertnstert.2017.01.017. PMID: 28292619
Obesity pandemic: causes, consequences, and solutions-but do we have the will?
Meldrum DR, Morris MA, Gambone JC
Fertil Steril 2017 Apr;107(4):833-839. Epub 2017 Mar 11 doi: 10.1016/j.fertnstert.2017.02.104. PMID: 28292617

Prognosis

Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Emotional eating and obesity in adults: the role of depression, sleep and genes.
Konttinen H
Proc Nutr Soc 2020 Aug;79(3):283-289. Epub 2020 Mar 26 doi: 10.1017/S0029665120000166. PMID: 32213213
Epigenetics in Human Obesity and Type 2 Diabetes.
Ling C, Rönn T
Cell Metab 2019 May 7;29(5):1028-1044. Epub 2019 Apr 11 doi: 10.1016/j.cmet.2019.03.009. PMID: 30982733Free PMC Article
Determinants and Consequences of Obesity.
Hruby A, Manson JE, Qi L, Malik VS, Rimm EB, Sun Q, Willett WC, Hu FB
Am J Public Health 2016 Sep;106(9):1656-62. Epub 2016 Jul 26 doi: 10.2105/AJPH.2016.303326. PMID: 27459460Free PMC Article
Pathophysiology of human visceral obesity: an update.
Tchernof A, Després JP
Physiol Rev 2013 Jan;93(1):359-404. doi: 10.1152/physrev.00033.2011. PMID: 23303913

Clinical prediction guides

Young-onset colorectal cancer.
Spaander MCW, Zauber AG, Syngal S, Blaser MJ, Sung JJ, You YN, Kuipers EJ
Nat Rev Dis Primers 2023 Apr 27;9(1):21. doi: 10.1038/s41572-023-00432-7. PMID: 37105987Free PMC Article
Genetics of Obesity: What We Have Learned Over Decades of Research.
Bouchard C
Obesity (Silver Spring) 2021 May;29(5):802-820. doi: 10.1002/oby.23116. PMID: 33899337
The hematologic consequences of obesity.
Purdy JC, Shatzel JJ
Eur J Haematol 2021 Mar;106(3):306-319. Epub 2020 Dec 13 doi: 10.1111/ejh.13560. PMID: 33270290Free PMC Article
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities.
Opazo-Ríos L, Mas S, Marín-Royo G, Mezzano S, Gómez-Guerrero C, Moreno JA, Egido J
Int J Mol Sci 2020 Apr 10;21(7) doi: 10.3390/ijms21072632. PMID: 32290082Free PMC Article
Does obesity cause type 2 diabetes mellitus (T2DM)? Or is it the opposite?
Malone JI, Hansen BC
Pediatr Diabetes 2019 Feb;20(1):5-9. Epub 2018 Nov 5 doi: 10.1111/pedi.12787. PMID: 30311716

Recent systematic reviews

Infections and Autoimmunity-The Immune System and Vitamin D: A Systematic Review.
Wimalawansa SJ
Nutrients 2023 Sep 2;15(17) doi: 10.3390/nu15173842. PMID: 37686873Free PMC Article
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.
Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P
Cochrane Database Syst Rev 2022 Feb 1;2(2022) doi: 10.1002/14651858.CD014217. PMID: 36321557Free PMC Article
The Impact of Obesity on Thyroid Autoimmunity and Dysfunction: A Systematic Review and Meta-Analysis.
Song RH, Wang B, Yao QM, Li Q, Jia X, Zhang JA
Front Immunol 2019;10:2349. Epub 2019 Oct 1 doi: 10.3389/fimmu.2019.02349. PMID: 31681268Free PMC Article
Pregnancy after bariatric surgery and adverse perinatal outcomes: A systematic review and meta-analysis.
Akhter Z, Rankin J, Ceulemans D, Ngongalah L, Ackroyd R, Devlieger R, Vieira R, Heslehurst N
PLoS Med 2019 Aug;16(8):e1002866. Epub 2019 Aug 6 doi: 10.1371/journal.pmed.1002866. PMID: 31386658Free PMC Article
Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint EFP/ORCA workshop on the boundaries between caries and periodontal diseases.
Chapple IL, Bouchard P, Cagetti MG, Campus G, Carra MC, Cocco F, Nibali L, Hujoel P, Laine ML, Lingstrom P, Manton DJ, Montero E, Pitts N, Rangé H, Schlueter N, Teughels W, Twetman S, Van Loveren C, Van der Weijden F, Vieira AR, Schulte AG
J Clin Periodontol 2017 Mar;44 Suppl 18:S39-S51. doi: 10.1111/jcpe.12685. PMID: 28266114

Supplemental Content

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