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Asthma-related traits, susceptibility to, 5(ASRT5)

MedGen UID:
370858
Concept ID:
C1970224
Finding
Synonyms: ASRT5; ASTHMA SUSCEPTIBILITY 5
 
Gene (location): IRAK3 (12q14.3)
 
Monarch Initiative: MONDO:0012607
OMIM®: 611064

Definition

Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. [from OMIM]

Recent clinical studies

Etiology

Ooka T, Zhu Z, Liang L, Celedon JC, Harmon B, Hahn A, Rhee EP, Freishtat RJ, Camargo CA Jr, Hasegawa K
Front Immunol 2022;13:1111723. Epub 2023 Feb 2 doi: 10.3389/fimmu.2022.1111723. PMID: 36818476Free PMC Article
Yan Q, Forno E, Herrera-Luis E, Pino-Yanes M, Yang G, Oh S, Acosta-Pérez E, Hu D, Eng C, Huntsman S, Rodriguez-Santana JR, Cloutier MM, Canino G, Burchard EG, Chen W, Celedón JC
J Allergy Clin Immunol 2021 Mar;147(3):933-940. Epub 2020 Sep 2 doi: 10.1016/j.jaci.2020.08.020. PMID: 32890573Free PMC Article
Hernandez-Pacheco N, Flores C, Oh SS, Burchard EG, Pino-Yanes M
Curr Allergy Asthma Rep 2016 Jul;16(8):53. doi: 10.1007/s11882-016-0635-4. PMID: 27393700
Martínez-Aguilar NE, Del Río-Navarro BE, Navarro-Olivos E, García-Ortíz H, Orozco L, Jiménez-Morales S
J Asthma 2015 Apr;52(3):232-9. Epub 2014 Oct 8 doi: 10.3109/02770903.2014.966913. PMID: 25233048
Martinez FD
Proc Am Thorac Soc 2007 Jul;4(3):221-5. doi: 10.1513/pats.200702-035AW. PMID: 17607003Free PMC Article

Therapy

Yan Q, Forno E, Herrera-Luis E, Pino-Yanes M, Yang G, Oh S, Acosta-Pérez E, Hu D, Eng C, Huntsman S, Rodriguez-Santana JR, Cloutier MM, Canino G, Burchard EG, Chen W, Celedón JC
J Allergy Clin Immunol 2021 Mar;147(3):933-940. Epub 2020 Sep 2 doi: 10.1016/j.jaci.2020.08.020. PMID: 32890573Free PMC Article
Martinez FD
Proc Am Thorac Soc 2007 Jul;4(3):221-5. doi: 10.1513/pats.200702-035AW. PMID: 17607003Free PMC Article

Clinical prediction guides

Batra J, Sharma SK, Ghosh B
Pharmacogenomics 2006 Jul;7(5):673-82. doi: 10.2217/14622416.7.5.673. PMID: 16886893
Tsai HJ, Kho JY, Shaikh N, Choudhry S, Naqvi M, Navarro D, Matallana H, Castro R, Lilly CM, Watson HG, Meade K, Lenoir M, Thyne S, Ziv E, Burchard EG
Hum Genet 2006 Jan;118(5):626-39. Epub 2005 Nov 5 doi: 10.1007/s00439-005-0080-2. PMID: 16273390Free PMC Article

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