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Polysubstance abuse, susceptibility to(PSAB)

MedGen UID:
339856
•Concept ID:
C1847831
•
Finding
Synonyms: Drug addiction, susceptibility to; PSAB
 
Gene (location): FAAH (1p33)
 
Monarch Initiative: MONDO:0011685
OMIM®: 606581

Recent clinical studies

Etiology

Neuroscience in addiction research.
Valentino RJ, Nair SG, Volkow ND
J Neural Transm (Vienna) 2024 May;131(5):453-459. Epub 2023 Nov 10 doi: 10.1007/s00702-023-02713-7. PMID: 37947883
Comorbid Health Conditions and Treatment Utilization among Individuals with Opioid Use Disorder Experiencing Homelessness.
Ali MM, Sutherland H, Rosenoff E
Subst Use Misuse 2021;56(4):571-574. Epub 2021 Feb 26 doi: 10.1080/10826084.2021.1884723. PMID: 33637031
Catechol-O-methyltransferase and dopamine receptor D4 gene variants: Possible association with substance abuse in Bangladeshi male.
Sonia JA, Kabir T, Islam MMT, Kabir Y
PLoS One 2021;16(2):e0246462. Epub 2021 Feb 5 doi: 10.1371/journal.pone.0246462. PMID: 33544778Free PMC Article
Genetic overlap and causality between substance use disorder and attention-deficit and hyperactivity disorder.
Vilar-Ribó L, Sánchez-Mora C, Rovira P, Richarte V, Corrales M, Fadeuilhe C, Arribas L, Casas M, Ramos-Quiroga JA, Ribasés M, Soler Artigas M
Am J Med Genet B Neuropsychiatr Genet 2021 Apr;186(3):140-150. Epub 2020 Nov 27 doi: 10.1002/ajmg.b.32827. PMID: 33244849
Longitudinal associations between susceptibility to tobacco use and the onset of other substances among U.S. youth.
Silveira ML, Conway KP, Everard CD, Sim HY, Kimmel HL, Compton WM
Prev Med 2020 Jun;135:106074. Epub 2020 Apr 1 doi: 10.1016/j.ypmed.2020.106074. PMID: 32243937Free PMC Article

Diagnosis

Genetic overlap and causality between substance use disorder and attention-deficit and hyperactivity disorder.
Vilar-Ribó L, Sánchez-Mora C, Rovira P, Richarte V, Corrales M, Fadeuilhe C, Arribas L, Casas M, Ramos-Quiroga JA, Ribasés M, Soler Artigas M
Am J Med Genet B Neuropsychiatr Genet 2021 Apr;186(3):140-150. Epub 2020 Nov 27 doi: 10.1002/ajmg.b.32827. PMID: 33244849
Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
Liu K, Zhao J, Chen C, Xu J, Bell RL, Hall FS, Koob GF, Volkow ND, Qing H, Lin Z
EBioMedicine 2020 Nov;61:103066. Epub 2020 Oct 21 doi: 10.1016/j.ebiom.2020.103066. PMID: 33096475Free PMC Article
The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism (ANKK1Taq1A) and Personality Traits in Addicted Subjects.
Grzywacz A, Chmielowiec J, Chmielowiec K, Mroczek B, Masiak J, Suchanecka A, Sipak-Szmigiel O, Szumilas K, Trybek G
Int J Environ Res Public Health 2019 Jul 27;16(15) doi: 10.3390/ijerph16152687. PMID: 31357601Free PMC Article
Attention deficit hyperactivity disorder and severity of substance use: the role of comorbid psychopathology.
Torok M, Darke S, Kaye S
Psychol Addict Behav 2012 Dec;26(4):974-9. Epub 2012 Apr 9 doi: 10.1037/a0027846. PMID: 22486329
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
Enoch MA, Hodgkinson CA, Yuan Q, Shen PH, Goldman D, Roy A
Biol Psychiatry 2010 Jan 1;67(1):20-7. doi: 10.1016/j.biopsych.2009.08.019. PMID: 19833324Free PMC Article

Therapy

Genetic overlap and causality between substance use disorder and attention-deficit and hyperactivity disorder.
Vilar-Ribó L, Sánchez-Mora C, Rovira P, Richarte V, Corrales M, Fadeuilhe C, Arribas L, Casas M, Ramos-Quiroga JA, Ribasés M, Soler Artigas M
Am J Med Genet B Neuropsychiatr Genet 2021 Apr;186(3):140-150. Epub 2020 Nov 27 doi: 10.1002/ajmg.b.32827. PMID: 33244849
Stress hormone responses to corticotropin-releasing hormone in substance abusers without severe comorbid psychiatric disease.
Contoreggi C, Herning RI, Na P, Gold PW, Chrousos G, Negro PJ, Better W, Cadet JL
Biol Psychiatry 2003 Nov 1;54(9):873-8. doi: 10.1016/s0006-3223(03)00167-7. PMID: 14573313
The relationship of cocaine to headache in polysubstance abusers.
Dhopesh V, Maany I, Herring C
Headache 1991 Jan;31(1):17-9. doi: 10.1111/j.1526-4610.1991.hed3101017.x. PMID: 2016163

Prognosis

Longitudinal associations between susceptibility to tobacco use and the onset of other substances among U.S. youth.
Silveira ML, Conway KP, Everard CD, Sim HY, Kimmel HL, Compton WM
Prev Med 2020 Jun;135:106074. Epub 2020 Apr 1 doi: 10.1016/j.ypmed.2020.106074. PMID: 32243937Free PMC Article
Executive functions and substance use: Relations in late adolescence and early adulthood.
Gustavson DE, Stallings MC, Corley RP, Miyake A, Hewitt JK, Friedman NP
J Abnorm Psychol 2017 Feb;126(2):257-270. Epub 2017 Jan 2 doi: 10.1037/abn0000250. PMID: 28045282Free PMC Article
Attention deficit hyperactivity disorder and severity of substance use: the role of comorbid psychopathology.
Torok M, Darke S, Kaye S
Psychol Addict Behav 2012 Dec;26(4):974-9. Epub 2012 Apr 9 doi: 10.1037/a0027846. PMID: 22486329
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
Enoch MA, Hodgkinson CA, Yuan Q, Shen PH, Goldman D, Roy A
Biol Psychiatry 2010 Jan 1;67(1):20-7. doi: 10.1016/j.biopsych.2009.08.019. PMID: 19833324Free PMC Article
Cannabis and schizophrenia: impact on onset, course, psychopathology and outcomes.
Bersani G, Orlandi V, Kotzalidis GD, Pancheri P
Eur Arch Psychiatry Clin Neurosci 2002 Apr;252(2):86-92. doi: 10.1007/s00406-002-0366-5. PMID: 12111342

Clinical prediction guides

Genetic overlap and causality between substance use disorder and attention-deficit and hyperactivity disorder.
Vilar-Ribó L, Sánchez-Mora C, Rovira P, Richarte V, Corrales M, Fadeuilhe C, Arribas L, Casas M, Ramos-Quiroga JA, Ribasés M, Soler Artigas M
Am J Med Genet B Neuropsychiatr Genet 2021 Apr;186(3):140-150. Epub 2020 Nov 27 doi: 10.1002/ajmg.b.32827. PMID: 33244849
Longitudinal associations between susceptibility to tobacco use and the onset of other substances among U.S. youth.
Silveira ML, Conway KP, Everard CD, Sim HY, Kimmel HL, Compton WM
Prev Med 2020 Jun;135:106074. Epub 2020 Apr 1 doi: 10.1016/j.ypmed.2020.106074. PMID: 32243937Free PMC Article
Executive functions and substance use: Relations in late adolescence and early adulthood.
Gustavson DE, Stallings MC, Corley RP, Miyake A, Hewitt JK, Friedman NP
J Abnorm Psychol 2017 Feb;126(2):257-270. Epub 2017 Jan 2 doi: 10.1037/abn0000250. PMID: 28045282Free PMC Article
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence.
Enoch MA, Hodgkinson CA, Yuan Q, Shen PH, Goldman D, Roy A
Biol Psychiatry 2010 Jan 1;67(1):20-7. doi: 10.1016/j.biopsych.2009.08.019. PMID: 19833324Free PMC Article
"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.
Uhl GR, Drgon T, Johnson C, Fatusin OO, Liu QR, Contoreggi C, Li CY, Buck K, Crabbe J
Biochem Pharmacol 2008 Jan 1;75(1):98-111. Epub 2007 Jul 25 doi: 10.1016/j.bcp.2007.06.042. PMID: 17764662Free PMC Article

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      Clinical tests in GTR
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    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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