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Neurotrophic keratopathy

MedGen UID:
87384
•Concept ID:
C0339296
•
Disease or Syndrome
Synonym: Neurotrophic keratitis
SNOMED CT: Anesthetic keratopathy (128080005); Neurotrophic keratopathy (128080005); Neuroparalytic keratopathy (128080005); Neurotrophic keratitis (128080005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0015290
Orphanet: ORPHA137596

Definition

Neurotrophic keratopathy is a rare degenerative disease of the cornea characterized by reduction or loss of corneal sensitivity that can be asymptomatic or present with red-eye and, during the early stages of the disease, a minor decrease in visual acuity. It eventually leads to loss of vision. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurotrophic keratopathy
Follow this link to review classifications for Neurotrophic keratopathy in Orphanet.

Professional guidelines

PubMed

Cenegermin for the treatment of dry eye disease.
Coco G, Piccotti G, Romano V, Ferro Desideri L, Vagge A, Traverso CE, Pellegrini M, Bruscolini A, Marenco M, Giannaccare G
Drugs Today (Barc) 2023 Mar;59(3):113-123. doi: 10.1358/dot.2023.59.3.3521858. PMID: 36847622
Neurotrophic keratopathy; its pathophysiology and treatment.
Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S
Histol Histopathol 2010 Jun;25(6):771-80. doi: 10.14670/HH-25.771. PMID: 20376784
Management of neurotrophic keratopathy.
Lambiase A, Rama P, Aloe L, Bonini S
Curr Opin Ophthalmol 1999 Aug;10(4):270-6. doi: 10.1097/00055735-199908000-00009. PMID: 10621535

Recent clinical studies

Etiology

Neurotrophic keratopathy: An updated understanding.
Neurotrophic Keratopathy Study Group
Ocul Surf 2023 Oct;30:129-138. Epub 2023 Sep 4 doi: 10.1016/j.jtos.2023.09.001. PMID: 37666470
Neurotrophic keratopathy and refractive surgery.
Kristan J, Kang JJ
Curr Opin Ophthalmol 2021 Jul 1;32(4):315-318. doi: 10.1097/ICU.0000000000000769. PMID: 33989233
Descemetocele.
Agarwal R, Nagpal R, Todi V, Sharma N
Surv Ophthalmol 2021 Jan-Feb;66(1):2-19. Epub 2020 Oct 13 doi: 10.1016/j.survophthal.2020.10.004. PMID: 33058926
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Neurotrophic keratopathy.
Dua HS, Said DG, Messmer EM, Rolando M, Benitez-Del-Castillo JM, Hossain PN, Shortt AJ, Geerling G, Nubile M, Figueiredo FC, Rauz S, Mastropasqua L, Rama P, Baudouin C
Prog Retin Eye Res 2018 Sep;66:107-131. Epub 2018 Apr 23 doi: 10.1016/j.preteyeres.2018.04.003. PMID: 29698813

Diagnosis

Neurotrophic keratopathy: current challenges and future prospects.
NaPier E, Camacho M, McDevitt TF, Sweeney AR
Ann Med 2022 Dec;54(1):666-673. doi: 10.1080/07853890.2022.2045035. PMID: 35243932Free PMC Article
The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas.
Yu FX, Lee PSY, Yang L, Gao N, Zhang Y, Ljubimov AV, Yang E, Zhou Q, Xie L
Prog Retin Eye Res 2022 Jul;89:101039. Epub 2022 Jan 4 doi: 10.1016/j.preteyeres.2021.101039. PMID: 34991965Free PMC Article
Neurotrophic keratopathy and refractive surgery.
Kristan J, Kang JJ
Curr Opin Ophthalmol 2021 Jul 1;32(4):315-318. doi: 10.1097/ICU.0000000000000769. PMID: 33989233
Descemetocele.
Agarwal R, Nagpal R, Todi V, Sharma N
Surv Ophthalmol 2021 Jan-Feb;66(1):2-19. Epub 2020 Oct 13 doi: 10.1016/j.survophthal.2020.10.004. PMID: 33058926
Neurotrophic keratopathy.
Pushker N, Dada T, Vajpayee RB, Gupta V, Aggrawal T, Titiyal JS
CLAO J 2001 Apr;27(2):100-7. PMID: 11352446

Therapy

Neurotrophic keratopathy and refractive surgery.
Kristan J, Kang JJ
Curr Opin Ophthalmol 2021 Jul 1;32(4):315-318. doi: 10.1097/ICU.0000000000000769. PMID: 33989233
Diabetic keratopathy.
Yeung A, Dwarakanathan S
Dis Mon 2021 May;67(5):101135. Epub 2021 Feb 4 doi: 10.1016/j.disamonth.2021.101135. PMID: 33551178
Cenegermin: A Review in Neurotrophic Keratitis.
Deeks ED, Lamb YN
Drugs 2020 Apr;80(5):489-494. doi: 10.1007/s40265-020-01289-w. PMID: 32185680
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Neurotrophic keratopathy.
Dua HS, Said DG, Messmer EM, Rolando M, Benitez-Del-Castillo JM, Hossain PN, Shortt AJ, Geerling G, Nubile M, Figueiredo FC, Rauz S, Mastropasqua L, Rama P, Baudouin C
Prog Retin Eye Res 2018 Sep;66:107-131. Epub 2018 Apr 23 doi: 10.1016/j.preteyeres.2018.04.003. PMID: 29698813

Prognosis

Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes.
Liu CY, Arteaga AC, Fung SE, Cortina MS, Leyngold IM, Aakalu VK
Ocul Surf 2021 Apr;20:163-172. Epub 2021 Feb 26 doi: 10.1016/j.jtos.2021.02.010. PMID: 33647470Free PMC Article
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies.
Pérez-Bartolomé F, Mingo Botín D, de Dompablo E, de Arriba P, Arnalich Montiel F, Muñoz Negrete FJ
Arch Soc Esp Oftalmol (Engl Ed) 2019 Apr;94(4):171-183. Epub 2019 Feb 2 doi: 10.1016/j.oftal.2019.01.002. PMID: 30718014
Neurotrophic keratitis.
Bonini S, Rama P, Olzi D, Lambiase A
Eye (Lond) 2003 Nov;17(8):989-95. doi: 10.1038/sj.eye.6700616. PMID: 14631406
Neurotrophic keratopathy.
Pushker N, Dada T, Vajpayee RB, Gupta V, Aggrawal T, Titiyal JS
CLAO J 2001 Apr;27(2):100-7. PMID: 11352446

Clinical prediction guides

Prevalence and clinical characteristics of neurotrophic keratopathy in hispanic population in northeastern Mexico.
Castillo-Macías A, Arreola-Martínez JE, Loya-García D, Valdez-García JE
Int Ophthalmol 2023 Sep;43(9):3257-3262. Epub 2023 May 4 doi: 10.1007/s10792-023-02726-x. PMID: 37140835Free PMC Article
Neurotrophic keratopathy: Pros and cons of current treatments.
Di Zazzo A, Coassin M, Varacalli G, Galvagno E, De Vincentis A, Bonini S
Ocul Surf 2019 Oct;17(4):619-623. Epub 2019 Sep 14 doi: 10.1016/j.jtos.2019.09.002. PMID: 31526824
Corneal Sensitivity as a Potential Marker of Diabetic Neuropathy.
Sitompul R
Acta Med Indones 2017 Apr;49(2):166-172. PMID: 28790232
Etiologies, Quantitative Hypoesthesia, and Clinical Outcomes of Neurotrophic Keratopathy.
Hsu HY, Modi D
Eye Contact Lens 2015 Sep;41(5):314-7. doi: 10.1097/ICL.0000000000000133. PMID: 25828513
Corneal changes in diabetes mellitus.
Bikbova G, Oshitari T, Tawada A, Yamamoto S
Curr Diabetes Rev 2012 Jul 1;8(4):294-302. doi: 10.2174/157339912800840479. PMID: 22587515

Recent systematic reviews

Efficacy of treatments for neurotrophic keratopathy: a systematic review and meta-analysis.
Roumeau S, Dutheil F, Sapin V, Baker JS, Watson SL, Pereira B, Chiambaretta F, Navel V
Graefes Arch Clin Exp Ophthalmol 2022 Aug;260(8):2623-2637. Epub 2022 Mar 7 doi: 10.1007/s00417-022-05602-z. PMID: 35254511
Corneal Neurotization: A Review of Pathophysiology and Outcomes.
Park JK, Charlson ES, Leyngold I, Kossler AL
Ophthalmic Plast Reconstr Surg 2020 Sep/Oct;36(5):431-437. doi: 10.1097/IOP.0000000000001583. PMID: 31923091

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