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Abnormality of the extrinsic pathway

MedGen UID:
869189
•Concept ID:
C4023611
•
Anatomical Abnormality
HPO: HP:0010988

Definition

An abnormality of the extrinsic pathway (also known as the tissue factor pathway) of the coagulation cascade. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the extrinsic pathway

Professional guidelines

PubMed

The role of apoptosis defects in malignant mesothelioma pathogenesis with an impact on prognosis and treatment.
Galani V, Varouktsi A, Papadatos SS, Mitselou A, Sainis I, Constantopoulos S, Dalavanga Y
Cancer Chemother Pharmacol 2019 Aug;84(2):241-253. Epub 2019 May 22 doi: 10.1007/s00280-019-03878-3. PMID: 31119375
Vorinostat and Mithramycin A in combination therapy as an interesting strategy for the treatment of Sézary T lymphoma: a transcriptomic approach.
Ragheb R, Venton G, Chelbi R, Bonnet N, Le Treut T, Ivanov V, Mercier C, Poulin P, Beaufils N, Gabert J, Suchon P, Rihet P, Loriod B, Kahn-Perlès B, Costello RT
Arch Dermatol Res 2017 Oct;309(8):611-623. Epub 2017 Jul 10 doi: 10.1007/s00403-017-1761-0. PMID: 28695331
Recent Updates in Melanocyte Function: The Use of Promising Bioactive Compounds for the Treatment of Hypopigmentary Disorders.
Ali SA, Naaz I, Zaidi KU, Ali AS
Mini Rev Med Chem 2017;17(9):785-798. doi: 10.2174/1389557516666161223153953. PMID: 28019642

Recent clinical studies

Etiology

Contemporary Concise Review 2022: Interstitial lung disease.
Smith DJF, Jenkins RG
Respirology 2023 Jul;28(7):627-635. Epub 2023 Apr 30 doi: 10.1111/resp.14511. PMID: 37121779
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes.
Gámez-Díaz L, Grimbacher B
Biomed J 2021 Aug;44(4):400-411. Epub 2021 Apr 19 doi: 10.1016/j.bj.2021.04.005. PMID: 34384744Free PMC Article
Environmental mechanisms of orofacial clefts.
Garland MA, Reynolds K, Zhou CJ
Birth Defects Res 2020 Nov;112(19):1660-1698. Epub 2020 Oct 30 doi: 10.1002/bdr2.1830. PMID: 33125192Free PMC Article
Coagulation Testing in the Core Laboratory.
Winter WE, Flax SD, Harris NS
Lab Med 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301
New findings on venous thrombogenesis.
Byrnes JR, Wolberg AS
Hamostaseologie 2017 Jan 31;37(1):25-35. Epub 2016 Nov 23 doi: 10.5482/HAMO-16-09-0034. PMID: 27878206Free PMC Article

Diagnosis

Autoimmune lymphoproliferative syndrome: A disorder of immune dysregulation.
Paskiewicz A, Niu J, Chang C
Autoimmun Rev 2023 Nov;22(11):103442. Epub 2023 Sep 6 doi: 10.1016/j.autrev.2023.103442. PMID: 37683818
Contemporary Concise Review 2022: Interstitial lung disease.
Smith DJF, Jenkins RG
Respirology 2023 Jul;28(7):627-635. Epub 2023 Apr 30 doi: 10.1111/resp.14511. PMID: 37121779
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes.
Gámez-Díaz L, Grimbacher B
Biomed J 2021 Aug;44(4):400-411. Epub 2021 Apr 19 doi: 10.1016/j.bj.2021.04.005. PMID: 34384744Free PMC Article
Coagulation Testing in the Core Laboratory.
Winter WE, Flax SD, Harris NS
Lab Med 2017 Nov 8;48(4):295-313. doi: 10.1093/labmed/lmx050. PMID: 29126301
Metabolic plasticity in heterogeneous pancreatic ductal adenocarcinoma.
Liang C, Qin Y, Zhang B, Ji S, Shi S, Xu W, Liu J, Xiang J, Liang D, Hu Q, Ni Q, Xu J, Yu X
Biochim Biophys Acta 2016 Dec;1866(2):177-188. Epub 2016 Sep 4 doi: 10.1016/j.bbcan.2016.09.001. PMID: 27600832

Therapy

Autoimmune lymphoproliferative syndrome: A disorder of immune dysregulation.
Paskiewicz A, Niu J, Chang C
Autoimmun Rev 2023 Nov;22(11):103442. Epub 2023 Sep 6 doi: 10.1016/j.autrev.2023.103442. PMID: 37683818
Immunotherapy for targeting cancer stem cells in hepatocellular carcinoma.
Dai X, Guo Y, Hu Y, Bao X, Zhu X, Fu Q, Zhang H, Tong Z, Liu L, Zheng Y, Zhao P, Fang W
Theranostics 2021;11(7):3489-3501. Epub 2021 Jan 19 doi: 10.7150/thno.54648. PMID: 33537099Free PMC Article
Plasticity of vagal afferent signaling in the gut.
Grabauskas G, Owyang C
Medicina (Kaunas) 2017;53(2):73-84. Epub 2017 Apr 10 doi: 10.1016/j.medici.2017.03.002. PMID: 28454890Free PMC Article
TRAIL/TRAIL-R in hematologic malignancies.
Testa U
J Cell Biochem 2010 May;110(1):21-34. doi: 10.1002/jcb.22549. PMID: 20336667
Coagulation in sepsis.
Amaral A, Opal SM, Vincent JL
Intensive Care Med 2004 Jun;30(6):1032-40. Epub 2004 May 18 doi: 10.1007/s00134-004-2291-8. PMID: 15148567

Prognosis

BH3 Mimetic Peptides: An Effective Strategy to Complement Anticancer Therapy.
Saraswathy SD, Mirunalini A, Karthikeyan K, Premkumar K
Curr Protein Pept Sci 2023;24(10):853-864. doi: 10.2174/1389203724666230822100131. PMID: 37608654
The current advances of lncRNAs in breast cancer immunobiology research.
Fonseca-Montaño MA, Vázquez-Santillán KI, Hidalgo-Miranda A
Front Immunol 2023;14:1194300. Epub 2023 Jun 5 doi: 10.3389/fimmu.2023.1194300. PMID: 37342324Free PMC Article
Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes.
Gámez-Díaz L, Grimbacher B
Biomed J 2021 Aug;44(4):400-411. Epub 2021 Apr 19 doi: 10.1016/j.bj.2021.04.005. PMID: 34384744Free PMC Article
Stroke and presence of patent foramen ovale in sickle cell disease.
Aggeli C, Polytarchou K, Dimitroglou Y, Patsourakos D, Delicou S, Vassilopoulou S, Tsiamis E, Tsioufis K
J Thromb Thrombolysis 2021 Oct;52(3):889-897. Epub 2021 Feb 26 doi: 10.1007/s11239-021-02398-3. PMID: 33638018Free PMC Article
The role of apoptosis defects in malignant mesothelioma pathogenesis with an impact on prognosis and treatment.
Galani V, Varouktsi A, Papadatos SS, Mitselou A, Sainis I, Constantopoulos S, Dalavanga Y
Cancer Chemother Pharmacol 2019 Aug;84(2):241-253. Epub 2019 May 22 doi: 10.1007/s00280-019-03878-3. PMID: 31119375

Clinical prediction guides

Immune checkpoint deficiencies and autoimmune lymphoproliferative syndromes.
Gámez-Díaz L, Grimbacher B
Biomed J 2021 Aug;44(4):400-411. Epub 2021 Apr 19 doi: 10.1016/j.bj.2021.04.005. PMID: 34384744Free PMC Article
Fantastic nuclear envelope herniations and where to find them.
Thaller DJ, Patrick Lusk C
Biochem Soc Trans 2018 Aug 20;46(4):877-889. Epub 2018 Jul 19 doi: 10.1042/BST20170442. PMID: 30026368Free PMC Article
Effects of cancer on platelets.
van Es N, Sturk A, Middeldorp S, Nieuwland R
Semin Oncol 2014 Jun;41(3):311-8. Epub 2014 Apr 24 doi: 10.1053/j.seminoncol.2014.04.015. PMID: 25023347
Cell and tissue interactions in carcinogenesis and metastasis and their clinical significance.
Tarin D
Semin Cancer Biol 2011 Apr;21(2):72-82. Epub 2010 Dec 13 doi: 10.1016/j.semcancer.2010.12.006. PMID: 21147229
TRAIL/TRAIL-R in hematologic malignancies.
Testa U
J Cell Biochem 2010 May;110(1):21-34. doi: 10.1002/jcb.22549. PMID: 20336667

Recent systematic reviews

Tissue factor in COVID-19-associated coagulopathy.
Subramaniam S, Kothari H, Bosmann M
Thromb Res 2022 Dec;220:35-47. Epub 2022 Oct 1 doi: 10.1016/j.thromres.2022.09.025. PMID: 36265412Free PMC Article

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