U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Decreased urine bicarbonate concentration

MedGen UID:
868008
•Concept ID:
C4022399
•
Finding
Synonym: Decreased urine HCO3 concentration
 
HPO: HP:0045011

Definition

Abnormally decreased concentration of hydrogencarbonate in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urine bicarbonate concentration

Professional guidelines

PubMed

Adverse events associated with currently used medical treatments for cystinuria and treatment goals: results from a series of 442 patients in France.
Prot-Bertoye C, Lebbah S, Daudon M, Tostivint I, Jais JP, Lillo-Le Louët A, Pontoizeau C, Cochat P, Bataille P, Bridoux F, Brignon P, Choquenet C, Combe C, Conort P, Decramer S, Doré B, Dussol B, Essig M, Frimat M, Gaunez N, Joly D, Le Toquin-Bernard S, Méjean A, Meria P, Morin D, N'Guyen HV, Normand M, Pietak M, Ronco P, Saussine C, Tsimaratos M, Friedlander G, Traxer O, Knebelmann B, Courbebaisse M; French Cystinuria Group
BJU Int 2019 Nov;124(5):849-861. Epub 2019 Mar 25 doi: 10.1111/bju.14721. PMID: 30801923
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure.
Moore KP, Holt SG, Patel RP, Svistunenko DA, Zackert W, Goodier D, Reeder BJ, Clozel M, Anand R, Cooper CE, Morrow JD, Wilson MT, Darley-Usmar V, Roberts LJ 2nd
J Biol Chem 1998 Nov 27;273(48):31731-7. doi: 10.1074/jbc.273.48.31731. PMID: 9822635

Recent clinical studies

Etiology

Risk factors for hip and vertebral fractures in chronic kidney disease: the CRIC study.
Hsu S, Bansal N, Denburg M, Ginsberg C, Hoofnagle AN, Isakova T, Ix JH, Robinson-Cohen C, Wolf M, Kestenbaum BR, de Boer IH, Zelnick LR
J Bone Miner Res 2024 May 2;39(4):433-442. doi: 10.1093/jbmr/zjae021. PMID: 38477777
Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study.
Tyson CC, Luciano A, Modliszewski JL, Corcoran DL, Bain JR, Muehlbauer M, Ilkayeva O, Pourafshar S, Allen J, Bowman C, Gung J, Asplin JR, Pendergast J, Svetkey LP, Lin PH, Scialla JJ
Am J Kidney Dis 2021 Jul;78(1):38-47. Epub 2021 Mar 31 doi: 10.1053/j.ajkd.2020.10.015. PMID: 33810868Free PMC Article
Tubular Acidification Defect in Adults with Sickle Cell Disease.
Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M
Clin J Am Soc Nephrol 2020 Jan 7;15(1):16-24. Epub 2019 Dec 10 doi: 10.2215/CJN.07830719. PMID: 31822527Free PMC Article
Uric acid nephrolithiasis.
Liebman SE, Taylor JG, Bushinsky DA
Curr Rheumatol Rep 2007 Jun;9(3):251-7. doi: 10.1007/s11926-007-0040-z. PMID: 17531180
Stones from bowel disease.
Worcester EM
Endocrinol Metab Clin North Am 2002 Dec;31(4):979-99. doi: 10.1016/s0889-8529(02)00035-x. PMID: 12474641

Diagnosis

Tubular Acidification Defect in Adults with Sickle Cell Disease.
Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M
Clin J Am Soc Nephrol 2020 Jan 7;15(1):16-24. Epub 2019 Dec 10 doi: 10.2215/CJN.07830719. PMID: 31822527Free PMC Article
Urinary metabolic abnormalities in children with idiopathic hematuria.
Valavi E, Nickavar A, Aeene A
J Pediatr Urol 2019 Apr;15(2):165.e1-165.e4. Epub 2018 Nov 10 doi: 10.1016/j.jpurol.2018.11.003. PMID: 30528095
The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions.
Gildea JJ, Xu P, Carlson JM, Gaglione RT, Bigler Wang D, Kemp BA, Reyes CM, McGrath HE, Carey RM, Jose PA, Felder RA
Am J Physiol Regul Integr Comp Physiol 2015 Dec 1;309(11):R1447-59. Epub 2015 Oct 7 doi: 10.1152/ajpregu.00150.2015. PMID: 26447209Free PMC Article
Insulin receptor-related receptor as an extracellular alkali sensor.
Deyev IE, Sohet F, Vassilenko KP, Serova OV, Popova NV, Zozulya SA, Burova EB, Houillier P, Rzhevsky DI, Berchatova AA, Murashev AN, Chugunov AO, Efremov RG, Nikol'sky NN, Bertelli E, Eladari D, Petrenko AG
Cell Metab 2011 Jun 8;13(6):679-89. doi: 10.1016/j.cmet.2011.03.022. PMID: 21641549Free PMC Article
Uric acid nephrolithiasis.
Liebman SE, Taylor JG, Bushinsky DA
Curr Rheumatol Rep 2007 Jun;9(3):251-7. doi: 10.1007/s11926-007-0040-z. PMID: 17531180

Therapy

Effect of Bicarbonate on Net Acid Excretion, Blood Pressure, and Metabolism in Patients With and Without CKD: The Acid Base Compensation in CKD Study.
Tyson CC, Luciano A, Modliszewski JL, Corcoran DL, Bain JR, Muehlbauer M, Ilkayeva O, Pourafshar S, Allen J, Bowman C, Gung J, Asplin JR, Pendergast J, Svetkey LP, Lin PH, Scialla JJ
Am J Kidney Dis 2021 Jul;78(1):38-47. Epub 2021 Mar 31 doi: 10.1053/j.ajkd.2020.10.015. PMID: 33810868Free PMC Article
Tubular Acidification Defect in Adults with Sickle Cell Disease.
Cazenave M, Audard V, Bertocchio JP, Habibi A, Baron S, Prot-Bertoye C, Berkenou J, Maruani G, Stehlé T, Cornière N, Ayari H, Friedlander G, Galacteros F, Houillier P, Bartolucci P, Courbebaisse M
Clin J Am Soc Nephrol 2020 Jan 7;15(1):16-24. Epub 2019 Dec 10 doi: 10.2215/CJN.07830719. PMID: 31822527Free PMC Article
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970
Chronic acetazolamide intoxication.
Watson WA, Garrelts JC, Zinn PD, Garriott JC, McLemore TL, Clementi WA
J Toxicol Clin Toxicol 1984-1985;22(6):549-63. doi: 10.3109/15563658408992584. PMID: 6535847

Prognosis

Association of urinary acidification function with the progression of diabetic kidney disease in patients with type 2 diabetes.
Zhu H, Liu X, Zhang C, Li Q, An X, Liu S, Wu L, Zhang B, Yuan Y, Xing C
J Diabetes Complications 2019 Nov;33(11):107419. Epub 2019 Aug 19 doi: 10.1016/j.jdiacomp.2019.107419. PMID: 31473080
Mechanisms for falling urine pH with age in stone formers.
Menezes CJ, Worcester EM, Coe FL, Asplin J, Bergsland KJ, Ko B
Am J Physiol Renal Physiol 2019 Jul 1;317(7):F65-F72. Epub 2019 Apr 24 doi: 10.1152/ajprenal.00066.2019. PMID: 31017011Free PMC Article
Does the exposure of urine samples to air affect diagnostic tests for urine acidification?
Yi JH, Shin HJ, Kim SM, Han SW, Kim HJ, Oh MS
Clin J Am Soc Nephrol 2012 Aug;7(8):1211-6. Epub 2012 Jun 14 doi: 10.2215/CJN.03230312. PMID: 22700881Free PMC Article
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
The electrolytes in hyponatremia.
Graber M, Corish D
Am J Kidney Dis 1991 Nov;18(5):527-45. doi: 10.1016/s0272-6386(12)80647-0. PMID: 1835285

Clinical prediction guides

Acetazolamide and human carbonic anhydrases: retrospect, review and discussion of an intimate relationship.
Tsikas D
J Enzyme Inhib Med Chem 2024 Dec;39(1):2291336. Epub 2023 Dec 11 doi: 10.1080/14756366.2023.2291336. PMID: 38078375
Mechanisms for falling urine pH with age in stone formers.
Menezes CJ, Worcester EM, Coe FL, Asplin J, Bergsland KJ, Ko B
Am J Physiol Renal Physiol 2019 Jul 1;317(7):F65-F72. Epub 2019 Apr 24 doi: 10.1152/ajprenal.00066.2019. PMID: 31017011Free PMC Article
Pathophysiology-based treatment of idiopathic calcium kidney stones.
Coe FL, Evan A, Worcester E
Clin J Am Soc Nephrol 2011 Aug;6(8):2083-92. doi: 10.2215/CJN.11321210. PMID: 21825103Free PMC Article
The electrolytes in hyponatremia.
Graber M, Corish D
Am J Kidney Dis 1991 Nov;18(5):527-45. doi: 10.1016/s0272-6386(12)80647-0. PMID: 1835285
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...