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Finger symphalangism

MedGen UID:
867041
•Concept ID:
C4021399
•
Anatomical Abnormality
Synonym: Symphalangism in fingers
 
HPO: HP:0009700

Definition

An abnormal union between bones or parts of bones of the fingers. The synonymous term "symphalangism of the hand" may be translated as fusions of bones of varying digree, that involve at least one phalangeal bone of the hand. If bony fusions are referred to as "Symphalangism" the fusion occurs in a proximo-distal axis. Fusions of bones of the fingers in a radio-ulnar axis are referred to as "bony" Syndactyly. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFinger symphalangism

Conditions with this feature

Multiple synostoses syndrome 2
MedGen UID:
331348
•Concept ID:
C1832708
•
Disease or Syndrome
Multiple synostoses syndrome-2 (SYNS2) is an autosomal dominant disorder characterized by progressive joint fusions of the fingers, wrists, ankles, and cervical spine; characteristic facies, including a broad hemicylindrical nose; and progressive conductive hearing loss (summary by Dawson et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of multiple synostoses syndrome, see SYNS1 (186500).
See: Condition Record
Chromosome 17P13.3, telomeric, duplication syndrome
MedGen UID:
390813
•Concept ID:
C2675492
•
Disease or Syndrome
See: Condition Record
Chromosome 17P13.3, telomeric, duplication syndrome
Multiple synostoses syndrome 2

Professional guidelines

PubMed

The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility.
Askarian S, Gholami M, Khalili-Tanha G, Tehrani NC, Joudi M, Khazaei M, Ferns GA, Hassanian SM, Avan A, Joodi M
Oral Maxillofac Surg 2023 Jun;27(2):177-186. Epub 2022 Apr 15 doi: 10.1007/s10006-022-01052-3. PMID: 35426585
Symbrachydactyly - Diagnosis, Function, and Treatment.
Woodside JC, Light TR
J Hand Surg Am 2016 Jan;41(1):135-43; quiz 143. Epub 2015 Aug 6 doi: 10.1016/j.jhsa.2015.06.114. PMID: 26254946
Management of knee deformities in children with arthrogryposis.
Lampasi M, Antonioli D, Donzelli O
Musculoskelet Surg 2012 Dec;96(3):161-9. Epub 2012 Aug 9 doi: 10.1007/s12306-012-0218-z. PMID: 22875688

Recent clinical studies

Etiology

Oligodactyly with Thumb.
Baek GH, Kim J
J Hand Surg Asian Pac Vol 2016 Oct;21(3):283-91. doi: 10.1142/S2424835516400087. PMID: 27595943
Polydactyly: phenotypes, genetics and classification.
Malik S
Clin Genet 2014 Mar;85(3):203-12. Epub 2013 Oct 18 doi: 10.1111/cge.12276. PMID: 24020795
Brachydactyly.
Temtamy SA, Aglan MS
Orphanet J Rare Dis 2008 Jun 13;3:15. doi: 10.1186/1750-1172-3-15. PMID: 18554391Free PMC Article
Macrodactyly.
Kotwal PP, Farooque M
J Bone Joint Surg Br 1998 Jul;80(4):651-3. doi: 10.1302/0301-620x.80b4.8489. PMID: 9699830
Craniofrontonasal dysplasia.
Kapusta L, Brunner HG, Hamel BC
Eur J Pediatr 1992 Nov;151(11):837-41. doi: 10.1007/BF01957936. PMID: 1468459

Diagnosis

Hypothesis: Symbrachydactyly.
Holmes LB, Nasri HZ
Am J Med Genet A 2022 Nov;188(11):3236-3241. Epub 2022 Sep 8 doi: 10.1002/ajmg.a.62941. PMID: 36073773
Symphalangism.
Pasha AS, Weimer M
Arthritis Rheumatol 2016 Sep;68(9):2327. doi: 10.1002/art.39752. PMID: 27214152
Oculodentodigital dysplasia.
Doshi DC, Limdi PK, Parekh NV, Gohil NR
Indian J Ophthalmol 2016 Mar;64(3):227-30. doi: 10.4103/0301-4738.180191. PMID: 27146935Free PMC Article
Brachydactyly.
Temtamy SA, Aglan MS
Orphanet J Rare Dis 2008 Jun 13;3:15. doi: 10.1186/1750-1172-3-15. PMID: 18554391Free PMC Article
Pfeiffer syndrome.
Vogels A, Fryns JP
Orphanet J Rare Dis 2006 Jun 1;1:19. doi: 10.1186/1750-1172-1-19. PMID: 16740155Free PMC Article

Therapy

Long-term Management of a Patient with Apert Syndrome.
Horiuchi S, Sato H, Iwasa A, Ichihara A, Tenshin H, Watanabe K, Hiasa M, Hashimoto I, Tanaka E
J Contemp Dent Pract 2021 Oct 1;22(10):1184-1190. PMID: 35197388
Patient-Reported Outcomes after Syndactyly Reconstruction.
Park E, Bi A, King EC, Adkinson JM
Plast Reconstr Surg 2020 May;145(5):1215-1221. doi: 10.1097/PRS.0000000000006743. PMID: 32332541
Methylphenidate use in pregnancy and lactation: a systematic review of evidence.
Bolea-Alamanac BM, Green A, Verma G, Maxwell P, Davies SJ
Br J Clin Pharmacol 2014 Jan;77(1):96-101. doi: 10.1111/bcp.12138. PMID: 23593966Free PMC Article
Infantile digital fibromatosis.
Taylor HO, Gellis SE, Schmidt BA, Upton J, Rogers GF
Ann Plast Surg 2008 Oct;61(4):472-6. doi: 10.1097/SAP.0b013e31816d8236. PMID: 18812724
Phenocopies.
Lenz W
J Med Genet 1973 Mar;10(1):34-49. doi: 10.1136/jmg.10.1.34. PMID: 4354695Free PMC Article

Prognosis

Brachydactyly.
Temtamy SA, Aglan MS
Orphanet J Rare Dis 2008 Jun 13;3:15. doi: 10.1186/1750-1172-3-15. PMID: 18554391Free PMC Article
Macrodactyly.
Kotwal PP, Farooque M
J Bone Joint Surg Br 1998 Jul;80(4):651-3. doi: 10.1302/0301-620x.80b4.8489. PMID: 9699830
Craniofrontonasal dysplasia.
Kapusta L, Brunner HG, Hamel BC
Eur J Pediatr 1992 Nov;151(11):837-41. doi: 10.1007/BF01957936. PMID: 1468459
Syndactyly.
Eaton CJ, Lister GD
Hand Clin 1990 Nov;6(4):555-75. PMID: 2176654
Syndactyly correction.
Colville J
Br J Plast Surg 1989 Jan;42(1):12-6. doi: 10.1016/s0007-1226(89)90106-9. PMID: 2537124

Clinical prediction guides

Reliability and validity of Vancouver Scar Scale and Withey score after syndactyly release.
Kim JK, Park JY, Shin YH, Yang J, Kim HY
J Pediatr Orthop B 2022 Nov 1;31(6):603-607. Epub 2022 May 3 doi: 10.1097/BPB.0000000000000983. PMID: 35502746
Patient-Reported Outcomes after Syndactyly Reconstruction.
Park E, Bi A, King EC, Adkinson JM
Plast Reconstr Surg 2020 May;145(5):1215-1221. doi: 10.1097/PRS.0000000000006743. PMID: 32332541
Oligodactyly with Thumb.
Baek GH, Kim J
J Hand Surg Asian Pac Vol 2016 Oct;21(3):283-91. doi: 10.1142/S2424835516400087. PMID: 27595943
Craniofrontonasal dysplasia.
Kapusta L, Brunner HG, Hamel BC
Eur J Pediatr 1992 Nov;151(11):837-41. doi: 10.1007/BF01957936. PMID: 1468459
Cleft hand.
Ogino T
Hand Clin 1990 Nov;6(4):661-71. PMID: 2176655

Recent systematic reviews

A Systematic Review of Vascularized and Nonvascularized Toe Transfer for Reconstruction of Congenital Hand Differences.
Meyers A, Bassiri Gharb B, Rampazzo A
Plast Reconstr Surg 2023 Jun 1;151(6):1256-1273. Epub 2022 Dec 26 doi: 10.1097/PRS.0000000000010116. PMID: 36728793
Surgical Treatment and Outcomes of Syndactyly: A Systematic Review.
Mende K, Watson A, Stewart DA
J Hand Surg Asian Pac Vol 2020 Mar;25(1):1-12. doi: 10.1142/S2424835520300017. PMID: 32000609
Methylphenidate use in pregnancy and lactation: a systematic review of evidence.
Bolea-Alamanac BM, Green A, Verma G, Maxwell P, Davies SJ
Br J Clin Pharmacol 2014 Jan;77(1):96-101. doi: 10.1111/bcp.12138. PMID: 23593966Free PMC Article

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