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Cytogenetically Normal Acute Myeloid Leukemia

MedGen UID:
825713
•Concept ID:
C3839868
•
Neoplastic Process
Synonyms: Acute myeloid leukemia with normal karyotype; Cytogenetically normal acute myeloid leukemia; Normal karyotype acute myeloid leukemia; Normal Karyotype Acute Myeloid Leukemia
SNOMED CT: Normal karyotype acute myeloid leukemia (703387000); Cytogenetically normal acute myeloid leukemia (703387000); Acute myeloid leukemia with normal karyotype (703387000)

Definition

Acute myeloid leukemia not associated with cytogenetic abnormalities. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCytogenetically Normal Acute Myeloid Leukemia

Professional guidelines

PubMed

Impact of genomics in the clinical management of patients with cytogenetically normal acute myeloid leukemia.
Falini B, Martelli MP
Best Pract Res Clin Haematol 2015 Jun-Sep;28(2-3):90-7. Epub 2015 Oct 22 doi: 10.1016/j.beha.2015.10.005. PMID: 26590764
Outcome of patients with distinct molecular genotypes and cytogenetically normal AML after allogeneic transplantation.
Schmid C, Labopin M, Socié G, Daguindau E, Volin L, Huynh A, Bourhis JH, Milpied N, Cornelissen J, Chevallier P, Maertens J, Jindra P, Blaise D, Lenhoff S, Ifrah N, Baron F, Ciceri F, Gorin C, Savani B, Giebel S, Polge E, Esteve J, Nagler A, Mohty M; Acute Leukemia Working Party of the European Group of Blood and Bone Marrow Transplantation
Blood 2015 Oct 22;126(17):2062-9. Epub 2015 Sep 8 doi: 10.1182/blood-2015-06-651562. PMID: 26351297
Management of patients with cytogenetically normal acute myeloid leukemia who have neither favorable nor unfavorable markers.
Walker AR, Marcucci G
J Natl Compr Canc Netw 2014 Apr;12(4):527-34. doi: 10.6004/jnccn.2014.0057. PMID: 24717571

Recent clinical studies

Etiology

Cytogenetically Normal Acute Myeloid Leukaemia at a Single Centre in South Africa.
Jenkins N, Blanshard LA, Stone M, Verburgh E, Oosthuizen J, Shires K
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):397-406. doi: 10.56875/2589-0646.1087. PMID: 37363984
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.
Pastore F, Pastore A, Rothenberg-Thurley M, Metzeler KH, Ksienzyk B, Schneider S, Bohlander SK, Braess J, Sauerland MC, Görlich D, Berdel WE, Wörmann B, von Bergwelt-Baildon MS, Hiddemann W, Spiekermann K
Cancer 2022 Dec 15;128(24):4213-4222. Epub 2022 Oct 22 doi: 10.1002/cncr.34495. PMID: 36271776
Management of patients with cytogenetically normal acute myeloid leukemia who have neither favorable nor unfavorable markers.
Walker AR, Marcucci G
J Natl Compr Canc Netw 2014 Apr;12(4):527-34. doi: 10.6004/jnccn.2014.0057. PMID: 24717571
Molecular prognostic factors in cytogenetically normal acute myeloid leukemia.
Walker A, Marcucci G
Expert Rev Hematol 2012 Oct;5(5):547-58. doi: 10.1586/ehm.12.45. PMID: 23146058Free PMC Article
IDH mutations in acute myeloid leukemia.
Rakheja D, Konoplev S, Medeiros LJ, Chen W
Hum Pathol 2012 Oct;43(10):1541-51. Epub 2012 Aug 20 doi: 10.1016/j.humpath.2012.05.003. PMID: 22917530

Diagnosis

Cytogenetically Normal Acute Myeloid Leukaemia at a Single Centre in South Africa.
Jenkins N, Blanshard LA, Stone M, Verburgh E, Oosthuizen J, Shires K
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):397-406. doi: 10.56875/2589-0646.1087. PMID: 37363984
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.
Pastore F, Pastore A, Rothenberg-Thurley M, Metzeler KH, Ksienzyk B, Schneider S, Bohlander SK, Braess J, Sauerland MC, Görlich D, Berdel WE, Wörmann B, von Bergwelt-Baildon MS, Hiddemann W, Spiekermann K
Cancer 2022 Dec 15;128(24):4213-4222. Epub 2022 Oct 22 doi: 10.1002/cncr.34495. PMID: 36271776
The Prognostic Significance of PDE7B in Cytogenetically Normal Acute Myeloid Leukemia.
Cao L, Zhang W, Liu X, Yang P, Wang J, Hu K, Zhang X, Liu W, He X, Jing H, Yuan X
Sci Rep 2019 Nov 18;9(1):16991. doi: 10.1038/s41598-019-53563-x. PMID: 31740742Free PMC Article
Management of patients with cytogenetically normal acute myeloid leukemia who have neither favorable nor unfavorable markers.
Walker AR, Marcucci G
J Natl Compr Canc Netw 2014 Apr;12(4):527-34. doi: 10.6004/jnccn.2014.0057. PMID: 24717571
Gene expression with prognostic implications in cytogenetically normal acute myeloid leukemia.
Baldus CD, Bullinger L
Semin Oncol 2008 Aug;35(4):356-64. doi: 10.1053/j.seminoncol.2008.04.006. PMID: 18692686

Therapy

Successful Treatment of Cytogenetically Normal Acute Myeloid Leukemia With Ten-Eleven Translocation 2-Isocitrate Dehydrogenase 2 and Additional Sex Comb-like 1-Nucleophosmin Co-mutations by HLA Haploidentical Stem Cell Transplantation: A Case Report and Literature Review.
Liu Y, Cao Y, Lin Y, Dong WM, Lin RR, Gu Q, Xie XB, Gu WY
Transplant Proc 2018 Apr;50(3):959-963. doi: 10.1016/j.transproceed.2018.01.003. PMID: 29661468
E-26 Transformation-specific Related Gene Expression and Outcomes in Cytogenetically Normal Acute Myeloid Leukemia: A Meta-analysis.
Fang JF, Yuan HN, Song YF, Sun PB, Zheng XL, Wang XJ
Chin Med J (Engl) 2017 Jun 20;130(12):1481-1490. doi: 10.4103/0366-6999.207474. PMID: 28584213Free PMC Article
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.
Masetti R, Bertuccio SN, Astolfi A, Chiarini F, Lonetti A, Indio V, De Luca M, Bandini J, Serravalle S, Franzoni M, Pigazzi M, Martelli AM, Basso G, Locatelli F, Pession A
J Hematol Oncol 2017 Jan 21;10(1):26. doi: 10.1186/s13045-017-0396-0. PMID: 28109323Free PMC Article
Impact of genomics in the clinical management of patients with cytogenetically normal acute myeloid leukemia.
Falini B, Martelli MP
Best Pract Res Clin Haematol 2015 Jun-Sep;28(2-3):90-7. Epub 2015 Oct 22 doi: 10.1016/j.beha.2015.10.005. PMID: 26590764
Integrative prognostic risk score in acute myeloid leukemia with normal karyotype.
Damm F, Heuser M, Morgan M, Wagner K, Görlich K, Grosshennig A, Hamwi I, Thol F, Surdziel E, Fiedler W, Lübbert M, Kanz L, Reuter C, Heil G, Delwel R, Löwenberg B, Valk PJ, Krauter J, Ganser A
Blood 2011 Apr 28;117(17):4561-8. Epub 2011 Mar 3 doi: 10.1182/blood-2010-08-303479. PMID: 21372155

Prognosis

Cytogenetically Normal Acute Myeloid Leukaemia at a Single Centre in South Africa.
Jenkins N, Blanshard LA, Stone M, Verburgh E, Oosthuizen J, Shires K
Hematol Oncol Stem Cell Ther 2023 May 23;16(4):397-406. doi: 10.56875/2589-0646.1087. PMID: 37363984
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.
Pastore F, Pastore A, Rothenberg-Thurley M, Metzeler KH, Ksienzyk B, Schneider S, Bohlander SK, Braess J, Sauerland MC, Görlich D, Berdel WE, Wörmann B, von Bergwelt-Baildon MS, Hiddemann W, Spiekermann K
Cancer 2022 Dec 15;128(24):4213-4222. Epub 2022 Oct 22 doi: 10.1002/cncr.34495. PMID: 36271776
The characteristics and clinical prognosis analysis of ASXL1 mutations in Chinese adult patients with primary cytogenetically normal acute myeloid leukemia by next-generation sequencing.
Xu J, Hao Z, Chen X, Hong M, Muyey DM, Chen X, Wang H
Leuk Lymphoma 2022 Oct;63(10):2321-2329. Epub 2022 Jun 2 doi: 10.1080/10428194.2022.2081323. PMID: 35652795
Management of patients with cytogenetically normal acute myeloid leukemia who have neither favorable nor unfavorable markers.
Walker AR, Marcucci G
J Natl Compr Canc Netw 2014 Apr;12(4):527-34. doi: 10.6004/jnccn.2014.0057. PMID: 24717571
Molecular prognostic factors in cytogenetically normal acute myeloid leukemia.
Walker A, Marcucci G
Expert Rev Hematol 2012 Oct;5(5):547-58. doi: 10.1586/ehm.12.45. PMID: 23146058Free PMC Article

Clinical prediction guides

A novel 5-gene prognostic signature to improve risk stratification of cytogenetically normal acute myeloid leukemia.
Deng C, Zeng T, Zhu P, Zhao S, Huang Z, Huang W, Zhang W, Huang X, Fu L
J Cancer Res Clin Oncol 2023 Sep;149(12):10015-10025. Epub 2023 Jun 1 doi: 10.1007/s00432-023-04884-y. PMID: 37258721
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis.
Pastore F, Pastore A, Rothenberg-Thurley M, Metzeler KH, Ksienzyk B, Schneider S, Bohlander SK, Braess J, Sauerland MC, Görlich D, Berdel WE, Wörmann B, von Bergwelt-Baildon MS, Hiddemann W, Spiekermann K
Cancer 2022 Dec 15;128(24):4213-4222. Epub 2022 Oct 22 doi: 10.1002/cncr.34495. PMID: 36271776
The Prognostic Significance of PDE7B in Cytogenetically Normal Acute Myeloid Leukemia.
Cao L, Zhang W, Liu X, Yang P, Wang J, Hu K, Zhang X, Liu W, He X, Jing H, Yuan X
Sci Rep 2019 Nov 18;9(1):16991. doi: 10.1038/s41598-019-53563-x. PMID: 31740742Free PMC Article
Molecular prognostic factors in cytogenetically normal acute myeloid leukemia.
Walker A, Marcucci G
Expert Rev Hematol 2012 Oct;5(5):547-58. doi: 10.1586/ehm.12.45. PMID: 23146058Free PMC Article
IDH mutations in acute myeloid leukemia.
Rakheja D, Konoplev S, Medeiros LJ, Chen W
Hum Pathol 2012 Oct;43(10):1541-51. Epub 2012 Aug 20 doi: 10.1016/j.humpath.2012.05.003. PMID: 22917530

Recent systematic reviews

E-26 Transformation-specific Related Gene Expression and Outcomes in Cytogenetically Normal Acute Myeloid Leukemia: A Meta-analysis.
Fang JF, Yuan HN, Song YF, Sun PB, Zheng XL, Wang XJ
Chin Med J (Engl) 2017 Jun 20;130(12):1481-1490. doi: 10.4103/0366-6999.207474. PMID: 28584213Free PMC Article

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