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Acute Monoblastic and Monocytic Leukemia

MedGen UID:
824521
•Concept ID:
C3831784
•
Neoplastic Process
Synonyms: Acute Monoblastic Leukemia and Acute Monocytic Leukemia; Acute Myeloid Leukemia M5

Definition

Acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage, including monoblasts, promonocytes, and monocytes. Bleeding disorders are common presenting features. [from NCI]

Professional guidelines

PubMed

Hyperleukocytosis and leukostasis: management of a medical emergency.
Giammarco S, Chiusolo P, Piccirillo N, Di Giovanni A, Metafuni E, Laurenti L, Sica S, Pagano L
Expert Rev Hematol 2017 Feb;10(2):147-154. Epub 2016 Dec 26 doi: 10.1080/17474086.2017.1270754. PMID: 27967252
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009
Acute monoblastic leukemia: diagnosis and treatment of ten cases.
McKenna RW, Bloomfield CD, Dick F, Nesbit ME, Brunning RD
Blood 1975 Oct;46(4):481-94. PMID: 169929

Recent clinical studies

Etiology

CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility.
Yuan ZH, Liu Q, Zhang Y, Liu HX, Zhao J, Zhu P
Ann Hematol 2011 Mar;90(3):293-9. Epub 2010 Sep 28 doi: 10.1007/s00277-010-1085-z. PMID: 20878158

Diagnosis

Unusual findings of acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): A multicenter study.
Gong X, Yu T, Tang Q, Fu Y, Wu J, Zhu Y, Tu H, Ge H, Lu X, Gong D, Zhao X
Int J Lab Hematol 2019 Jun;41(3):380-386. Epub 2019 Feb 22 doi: 10.1111/ijlh.12987. PMID: 30793839
Histiocytic differentiation in acute monocytic leukemia.
Ru YX, Dong SX, Zhao SX, Liang HY, Wang HJ, Hu X, Mi YC, Wang JX
Ultrastruct Pathol 2016;40(1):18-23. doi: 10.3109/01913123.2015.1120838. PMID: 26771450

Prognosis

Unusual findings of acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): A multicenter study.
Gong X, Yu T, Tang Q, Fu Y, Wu J, Zhu Y, Tu H, Ge H, Lu X, Gong D, Zhao X
Int J Lab Hematol 2019 Jun;41(3):380-386. Epub 2019 Feb 22 doi: 10.1111/ijlh.12987. PMID: 30793839

Clinical prediction guides

Unusual findings of acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): A multicenter study.
Gong X, Yu T, Tang Q, Fu Y, Wu J, Zhu Y, Tu H, Ge H, Lu X, Gong D, Zhao X
Int J Lab Hematol 2019 Jun;41(3):380-386. Epub 2019 Feb 22 doi: 10.1111/ijlh.12987. PMID: 30793839

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