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Supraclavicular lymphadenopathy

MedGen UID:
677127
•Concept ID:
C0749155
•
Disease or Syndrome
SNOMED CT: Supraclavicular lymphadenopathy (127088000)
 
HPO: HP:0034750

Definition

Enlarged lymph node located just above the clavicle (collarbone). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSupraclavicular lymphadenopathy

Professional guidelines

PubMed

Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.
Garreffa E, Hamad A, O'Sullivan CC, Hazim AZ, York J, Puri S, Turnbull A, Robertson JF, Goetz MP
Eur J Cancer 2021 Dec;159:38-51. Epub 2021 Oct 11 doi: 10.1016/j.ejca.2021.09.033. PMID: 34731748Free PMC Article
The management of locally advanced breast cancer: a combined modality approach.
Kantarjian HM, Hortobagyi GN, Smith TL, Blumenschein GR, Montague E, Buzdar AU, Martin RG
Eur J Cancer Clin Oncol 1984 Nov;20(11):1353-61. doi: 10.1016/0277-5379(84)90053-1. PMID: 6548710

Recent clinical studies

Etiology

Survival in esophageal cancer with nonregional lymphadenopathy: a propensity score-matched analysis.
Tankel J, Sakalla R, Boukhili N, Dehghani M, Spicer J, Najmeh S, Cools-Lartigue J, Asselah J, Soldera S, Alcindor T, Alfieri J, David M, Mueller C, Ferri L
J Gastrointest Surg 2024 Jun;28(6):916-922. Epub 2024 Apr 2 doi: 10.1016/j.gassur.2024.03.031. PMID: 38574965
Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.
Garreffa E, Hamad A, O'Sullivan CC, Hazim AZ, York J, Puri S, Turnbull A, Robertson JF, Goetz MP
Eur J Cancer 2021 Dec;159:38-51. Epub 2021 Oct 11 doi: 10.1016/j.ejca.2021.09.033. PMID: 34731748Free PMC Article
Prognostic significance of supraclavicular lymphadenopathy in patients with high-grade serous ovarian cancer.
Cybulska P, Hayes SA, Spirtos A, Rafizadeh MJ, Filippova OT, Leitao M, Zivanovic O, Sonoda Y, Mueller J, Lakhman Y, Long K, Chi DS
Int J Gynecol Cancer 2019 Nov;29(9):1377-1380. Epub 2019 Oct 1 doi: 10.1136/ijgc-2019-000829. PMID: 31575614Free PMC Article
Supraclavicular lymphadenopathy: should it be perceived as the virchow's node of head and neck tumors?
Acar T, Savas R, Kocacelebi K, Guneyli S
Oncol Res Treat 2014;37(12):726-30. Epub 2014 Nov 21 doi: 10.1159/000369429. PMID: 25531718
Diagnostic evaluation of supraclavicular lymphadenopathy.
Saifullah MK, Sutradhar SR, Khan NA, Haque MF, Hasan I, Sumon SM, Islam MZ, Rahman S, Barman TK, Rahman A, Datta PK, Ferdous J, Chowdhury SA, Miah AH, Pandit H
Mymensingh Med J 2013 Jan;22(1):8-14. PMID: 23416801

Diagnosis

Mediastinal Presentation of Testicular Embryonal Carcinoma.
Chandra S, McKean H
S D Med 2023 Aug;76(8):342-344. PMID: 37734076
What's in a node? The clinical and radiologic significance of Virchow's node.
Adler C, Lubner MG, Menias CO, Lubner SJ, Dahiya N
Abdom Radiol (NY) 2022 Jun;47(6):2244-2253. Epub 2022 Mar 22 doi: 10.1007/s00261-022-03487-4. PMID: 35316379
Prognostic significance of supraclavicular lymphadenopathy in patients with high-grade serous ovarian cancer.
Cybulska P, Hayes SA, Spirtos A, Rafizadeh MJ, Filippova OT, Leitao M, Zivanovic O, Sonoda Y, Mueller J, Lakhman Y, Long K, Chi DS
Int J Gynecol Cancer 2019 Nov;29(9):1377-1380. Epub 2019 Oct 1 doi: 10.1136/ijgc-2019-000829. PMID: 31575614Free PMC Article
Diagnostic evaluation of supraclavicular lymphadenopathy.
Saifullah MK, Sutradhar SR, Khan NA, Haque MF, Hasan I, Sumon SM, Islam MZ, Rahman S, Barman TK, Rahman A, Datta PK, Ferdous J, Chowdhury SA, Miah AH, Pandit H
Mymensingh Med J 2013 Jan;22(1):8-14. PMID: 23416801
Supraclavicular metastases from distant primaries: what is the role of the head and neck surgeon?
Aldridge T, Kusanale A, Colbert S, Brennan PA
Br J Oral Maxillofac Surg 2013 Jun;51(4):288-93. Epub 2012 May 14 doi: 10.1016/j.bjoms.2012.03.016. PMID: 22591766

Therapy

COVID-19 vaccination-associated ipsilateral supraclavicular lymphadenopathy.
Jalani N, Tadj D
Aust J Gen Pract 2021 Dec 10;50 doi: 10.31128/AJGP-COVID-54. PMID: 35398876
Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.
Garreffa E, Hamad A, O'Sullivan CC, Hazim AZ, York J, Puri S, Turnbull A, Robertson JF, Goetz MP
Eur J Cancer 2021 Dec;159:38-51. Epub 2021 Oct 11 doi: 10.1016/j.ejca.2021.09.033. PMID: 34731748Free PMC Article
Supraclavicular lymphadenopathy following COVID-19 vaccination: an increasing presentation to the two-week wait neck lump clinic?
Mitchell OR, Dave R, Bekker J, Brennan PA
Br J Oral Maxillofac Surg 2021 Apr;59(3):384-385. Epub 2021 Feb 15 doi: 10.1016/j.bjoms.2021.02.002. PMID: 33685772Free PMC Article
Neck and supraclavicular lymphadenopathy secondary to 9-valent human papillomavirus vaccination.
Pereira MP, Flores P, Neto AS
BMJ Case Rep 2019 Nov 5;12(11) doi: 10.1136/bcr-2019-231582. PMID: 31694828Free PMC Article
When to Treat Adults Like Children: Optimizing Therapy for Lymphoblastic Lymphoma in Young Adults.
O'Dwyer KM, Advani AS
J Clin Oncol 2016 Feb 20;34(6):533-8. Epub 2015 Dec 23 doi: 10.1200/JCO.2015.64.7156. PMID: 26700121

Prognosis

Evaluation of Peripheral Lymphadenopathies in Children in a Single Center: Predictive Factors for Malignancy.
Işık P, Belen Apak FB, Demir TA
Klin Padiatr 2024 May;236(3):173-179. Epub 2024 May 10 doi: 10.1055/a-2266-0722. PMID: 38729128
Survival in esophageal cancer with nonregional lymphadenopathy: a propensity score-matched analysis.
Tankel J, Sakalla R, Boukhili N, Dehghani M, Spicer J, Najmeh S, Cools-Lartigue J, Asselah J, Soldera S, Alcindor T, Alfieri J, David M, Mueller C, Ferri L
J Gastrointest Surg 2024 Jun;28(6):916-922. Epub 2024 Apr 2 doi: 10.1016/j.gassur.2024.03.031. PMID: 38574965
Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.
Garreffa E, Hamad A, O'Sullivan CC, Hazim AZ, York J, Puri S, Turnbull A, Robertson JF, Goetz MP
Eur J Cancer 2021 Dec;159:38-51. Epub 2021 Oct 11 doi: 10.1016/j.ejca.2021.09.033. PMID: 34731748Free PMC Article
Prognostic significance of supraclavicular lymphadenopathy in patients with high-grade serous ovarian cancer.
Cybulska P, Hayes SA, Spirtos A, Rafizadeh MJ, Filippova OT, Leitao M, Zivanovic O, Sonoda Y, Mueller J, Lakhman Y, Long K, Chi DS
Int J Gynecol Cancer 2019 Nov;29(9):1377-1380. Epub 2019 Oct 1 doi: 10.1136/ijgc-2019-000829. PMID: 31575614Free PMC Article
Breast cancer metastases to the head and neck: Case series and literature review.
Tracy JC, Mildenhall NR, Wein RO, O'Leary MA
Ear Nose Throat J 2017 Mar;96(3):E21-E24. doi: 10.1177/014556131709600321. PMID: 28346651

Clinical prediction guides

Survival in esophageal cancer with nonregional lymphadenopathy: a propensity score-matched analysis.
Tankel J, Sakalla R, Boukhili N, Dehghani M, Spicer J, Najmeh S, Cools-Lartigue J, Asselah J, Soldera S, Alcindor T, Alfieri J, David M, Mueller C, Ferri L
J Gastrointest Surg 2024 Jun;28(6):916-922. Epub 2024 Apr 2 doi: 10.1016/j.gassur.2024.03.031. PMID: 38574965
Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.
Garreffa E, Hamad A, O'Sullivan CC, Hazim AZ, York J, Puri S, Turnbull A, Robertson JF, Goetz MP
Eur J Cancer 2021 Dec;159:38-51. Epub 2021 Oct 11 doi: 10.1016/j.ejca.2021.09.033. PMID: 34731748Free PMC Article
Supraclavicular lymphadenopathy: should it be perceived as the virchow's node of head and neck tumors?
Acar T, Savas R, Kocacelebi K, Guneyli S
Oncol Res Treat 2014;37(12):726-30. Epub 2014 Nov 21 doi: 10.1159/000369429. PMID: 25531718
Diagnostic evaluation of supraclavicular lymphadenopathy.
Saifullah MK, Sutradhar SR, Khan NA, Haque MF, Hasan I, Sumon SM, Islam MZ, Rahman S, Barman TK, Rahman A, Datta PK, Ferdous J, Chowdhury SA, Miah AH, Pandit H
Mymensingh Med J 2013 Jan;22(1):8-14. PMID: 23416801
Diagnostic value of fine-needle aspiration in supraclavicular lymphadenopathy: a study of 106 patients and review of literature.
Nasuti JF, Mehrotra R, Gupta PK
Diagn Cytopathol 2001 Dec;25(6):351-5. doi: 10.1002/dc.10002. PMID: 11747230

Recent systematic reviews

Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.
Garreffa E, Hamad A, O'Sullivan CC, Hazim AZ, York J, Puri S, Turnbull A, Robertson JF, Goetz MP
Eur J Cancer 2021 Dec;159:38-51. Epub 2021 Oct 11 doi: 10.1016/j.ejca.2021.09.033. PMID: 34731748Free PMC Article

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