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Spindle cell nevus

MedGen UID:
60220
•Concept ID:
C0206738
•
Neoplastic Process
Synonyms: Nevi, Spindle Cell; Nevus, Spindle Cell; Spindle Cell Nevi; Spindle Cell Nevus
SNOMED CT: Spindle cell nevus (810003); Spindle cell nevus (253038006)
 
Monarch Initiative: MONDO:0044796

Definition

A nevus characterized by the presence of spindle-shaped melanocytes. [from NCI]

Professional guidelines

PubMed

Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
The complex management of atypical Spitz tumours.
Massi D, De Giorgi V, Mandalà M
Pathology 2016 Feb;48(2):132-41. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.003. PMID: 27020385
Differential diagnosis of heavily pigmented melanocytic lesions: challenges and diagnostic approach.
Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414

Recent clinical studies

Etiology

Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Spitz Tumors of the Skin.
Menezes FD, Mooi WJ
Surg Pathol Clin 2017 Jun;10(2):281-298. Epub 2017 Mar 31 doi: 10.1016/j.path.2017.01.004. PMID: 28477881
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Diagnosis

Spitz melanocytic tumours - a review.
Yeh I, Busam KJ
Histopathology 2022 Jan;80(1):122-134. doi: 10.1111/his.14583. PMID: 34958498
Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society.
Lallas A, Apalla Z, Ioannides D, Lazaridou E, Kyrgidis A, Broganelli P, Alfano R, Zalaudek I, Argenziano G; International Dermoscopy Society
Br J Dermatol 2017 Sep;177(3):645-655. Epub 2017 Jul 19 doi: 10.1111/bjd.15339. PMID: 28118479
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Therapy

First-line axitinib therapy is less effective in metastatic renal cell carcinoma with spindle histology.
Numakura K, Kobayashi M, Muto Y, Sekine Y, Takahashi M, Kashima S, Yamamoto R, Koizumi A, Nara T, Saito M, Narita S, Nanjyo H, Habuchi T
Sci Rep 2020 Nov 18;10(1):20089. doi: 10.1038/s41598-020-77135-6. PMID: 33208816Free PMC Article
Spitz nevus and infliximab: association or coincidence?
Queirós CS, Laureano-Oliveira A, Lopéz-Presa D, Filipe P
An Bras Dermatol 2020 Sep-Oct;95(5):615-618. Epub 2020 Jul 12 doi: 10.1016/j.abd.2020.01.008. PMID: 32711929Free PMC Article
Safety and efficacy of sunitinib for advanced non-clear cell renal cell carcinoma.
Shi HZ, Tian J, Li CL
Asia Pac J Clin Oncol 2015 Dec;11(4):328-33. Epub 2015 Oct 15 doi: 10.1111/ajco.12408. PMID: 26471774
Epithelioid and fusiform blue nevus of chronically sun-damaged skin, an entity distinct from the epithelioid blue nevus of the Carney complex.
Yazdan P, Haghighat Z, Guitart J, Gerami P
Am J Surg Pathol 2013 Jan;37(1):81-8. doi: 10.1097/PAS.0b013e3182608fa5. PMID: 22892599
Update in molecular diagnostics in melanocytic neoplasms.
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066

Prognosis

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Age and Melanocytic Lesions.
Shannon AB, Song Y, Xu X, Karakousis GC
Surg Oncol Clin N Am 2020 Jul;29(3):369-386. doi: 10.1016/j.soc.2020.02.005. PMID: 32482314
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article
Spitzoid melanoma.
Kamino H
Clin Dermatol 2009 Nov-Dec;27(6):545-55. doi: 10.1016/j.clindermatol.2008.09.013. PMID: 19880042

Clinical prediction guides

Spitz Nevus: Review and Update.
Brown A, Sawyer JD, Neumeister MW
Clin Plast Surg 2021 Oct;48(4):677-686. Epub 2021 Aug 18 doi: 10.1016/j.cps.2021.06.002. PMID: 34503728
Evolution of Spitz Nevi.
Emiroglu N, Yıldız P, Biyik Ozkaya D, Bahalı AG, Su O, Onsun N
Pediatr Dermatol 2017 Jul;34(4):438-445. Epub 2017 Jun 30 doi: 10.1111/pde.13184. PMID: 28664989
Atypical Spitz Tumors: A Diagnostic Challenge.
Harms KL, Lowe L, Fullen DR, Harms PW
Arch Pathol Lab Med 2015 Oct;139(10):1263-70. doi: 10.5858/arpa.2015-0207-RA. PMID: 26414472
Desmoplastic melanoma: a review.
Chen LL, Jaimes N, Barker CA, Busam KJ, Marghoob AA
J Am Acad Dermatol 2013 May;68(5):825-33. Epub 2012 Dec 23 doi: 10.1016/j.jaad.2012.10.041. PMID: 23267722Free PMC Article
Spindle cell melanocytic lesions: part II--an approach to intradermal proliferations and horizontally oriented lesions.
Sade S, Al Habeeb A, Ghazarian D
J Clin Pathol 2010 May;63(5):391-409. doi: 10.1136/jcp.2010.075440. PMID: 20418231

Recent systematic reviews

Melanoma in children: A systematic review and individual patient meta-analysis.
Pampena R, Piccolo V, Muscianese M, Kyrgidis A, Lai M, Russo T, Briatico G, Di Brizzi EV, Cascone G, Pellerone S, Longo C, Moscarella E, Argenziano G
J Eur Acad Dermatol Venereol 2023 Sep;37(9):1758-1776. Epub 2023 Jun 2 doi: 10.1111/jdv.19220. PMID: 37210654
Clinical management of melanocytic tumours of uncertain malignant potential (MelTUMPs), including melanocytomas: A systematic review and meta-analysis.
Varey AHR, Williams GJ, Lo SN, Taing CY, Maurichi A, Santinami M, Scolyer RA, Thompson JF
J Eur Acad Dermatol Venereol 2023 May;37(5):859-870. Epub 2022 Nov 7 doi: 10.1111/jdv.18665. PMID: 36251355
Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review.
Lallas A, Kyrgidis A, Ferrara G, Kittler H, Apalla Z, Castagnetti F, Longo C, Moscarella E, Piana S, Zalaudek I, Argenziano G
Lancet Oncol 2014 Apr;15(4):e178-83. doi: 10.1016/S1470-2045(13)70608-9. PMID: 24694641

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