U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Complete unilateral cleft lip

MedGen UID:
510610
•Concept ID:
C0158651
•
Congenital Abnormality
HPO: HP:5201001

Definition

Unilateral cleft lip cleft that starts from the bottom of the upper lip and reaches the nasal cavity. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComplete unilateral cleft lip

Professional guidelines

PubMed

Occlusal Outcome of Orthodontic Treatment for Patients With Complete Cleft Lip and Palate.
Stonehouse-Smith D, Rahman ANAA, Mooney J, Bellardie H
Cleft Palate Craniofac J 2022 Jan;59(1):79-85. Epub 2021 Mar 24 doi: 10.1177/1055665621996116. PMID: 33757373
Evaluation of unilateral cleft lip and palate treatment: long term results.
Enemark H, Bolund S, Jørgensen I
Cleft Palate J 1990 Oct;27(4):354-61. doi: 10.1597/1545-1569(1990)027<0354:eoucla>2.3.co;2. PMID: 2253381
Secondary bonegrafting in unilateral cleft lip palate patients: indications and treatment procedure.
Enemark H, Krantz-Simonsen E, Schramm JE
Int J Oral Surg 1985 Feb;14(1):2-10. doi: 10.1016/s0300-9785(85)80003-x. PMID: 3921475

Recent clinical studies

Etiology

Piriform Rim Asymmetry in Unilateral Cleft Lip and Palate Patients Before Orthognathic Surgery.
Ritto FG, Mealy T, Canellas JV, Padwa BL, Smith KS
J Oral Maxillofac Surg 2023 Nov;81(11):1344-1352. Epub 2023 Aug 9 doi: 10.1016/j.joms.2023.08.003. PMID: 37640235
The Melbourne Classification of the Complete Unilateral Cleft Lip Based on Hypoplasia.
Van Slyke AC, Chong DK
J Craniofac Surg 2022 Mar-Apr 01;33(2):380-384. doi: 10.1097/SCS.0000000000008277. PMID: 35385902Free PMC Article
Long-Term Results of the Murawski Unilateral Cleft Lip Repair.
Murawski EL, Gawrych EH, Cutting CB, Sifakis ED, Wang Q, Tao Y
Plast Reconstr Surg 2022 Feb 1;149(2):254e-260e. doi: 10.1097/PRS.0000000000008788. PMID: 35077424
Final Posttreatment Occlusion in Patients With Unilateral Cleft Lip and Palate.
Staudt CB, Bollhalder J, Eichenberger M, La Scala G, Herzog G, Wiedemeier DB, Antonarakis GS
Cleft Palate Craniofac J 2022 Jul;59(7):899-909. Epub 2021 Jul 8 doi: 10.1177/10556656211028506. PMID: 34235980Free PMC Article
The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593

Diagnosis

Dynamic changes in nasal symmetry after presurgical nasoalveolar molding in infants with complete unilateral cleft lip and palate.
Thakur S, Singh A, Diwana VK, Rani A, Thakur NS
Afr J Paediatr Surg 2020 Jan-Jun;17(1-2):1-4. doi: 10.4103/ajps.AJPS_5_18. PMID: 33106444Free PMC Article
Outcome of Patients with Complete Unilateral Cleft Lip and Palate: 20-Year Follow-Up of a Treatment Protocol.
Pai BCJ, Hung YT, Wang RSH, Lo LJ
Plast Reconstr Surg 2019 Feb;143(2):359e-367e. doi: 10.1097/PRS.0000000000005216. PMID: 30531628
Postoperative alar base symmetry in complete unilateral cleft lip and palate:A prospective study.
Vyloppilli S, Krishnakumar KS, Sayd S, Latheef S, Narayanan SV, Pati A
J Plast Reconstr Aesthet Surg 2017 Nov;70(11):1614-1619. Epub 2017 Jun 9 doi: 10.1016/j.bjps.2017.05.052. PMID: 28676318
A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
Semb G, Enemark H, Friede H, Paulin G, Lilja J, Rautio J, Andersen M, Åbyholm F, Lohmander A, Shaw W, Mølsted K, Heliövaara A, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Whitby D, Leonard A, Neovius E, Elander A, Willadsen E, Bannister RP, Bradbury E, Henningsson G, Persson C, Eyres P, Emborg B, Kisling-Møller M, Küseler A, Granhof Black B, Schöps A, Bau A, Boers M, Andersen HS, Jeppesen K, Marxen D, Paaso M, Hölttä E, Alaluusua S, Turunen L, Humerinta K, Elfving-Little U, Tørdal IB, Kjøll L, Aukner R, Hide Ø, Feragen KB, Rønning E, Skaare P, Brinck E, Semmingsen AM, Lindberg N, Bowden M, Davies J, Mooney J, Bellardie H, Schofield N, Nyberg J, Lundberg M, Karsten AL, Larson M, Holmefjord A, Reisæter S, Pedersen NH, Rasmussen T, Tindlund R, Sæle P, Blomhoff R, Jacobsen G, Havstam C, Rizell S, Enocson L, Hagberg C, Najar Chalien M, Paganini A, Lundeborg I, Marcusson A, Mjönes AB, Gustavsson A, Hayden C, McAleer E, Slevan E, Gregg T, Worthington H
J Plast Surg Hand Surg 2017 Feb;51(1):2-13. doi: 10.1080/2000656X.2016.1263202. PMID: 28218559
Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 2. Surgical results.
Rautio J, Andersen M, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Åbyholm F, Whitby D, Leonard A, Lilja J, Neovius E, Elander A, Heliövaara A, Eyres P, Semb G
J Plast Surg Hand Surg 2017 Feb;51(1):14-20. doi: 10.1080/2000656X.2016.1254646. PMID: 28218552

Therapy

Early or delayed palatoplasty in complete unilateral cleft lip and palate patients? A systematic review of the effects on maxillary growth.
Salgado KR, Wendt AR, Fernandes Fagundes NC, Maia LC, Normando D, Leão PB
J Craniomaxillofac Surg 2019 Nov;47(11):1690-1698. Epub 2019 Jul 3 doi: 10.1016/j.jcms.2019.06.017. PMID: 31677987
A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
Semb G, Enemark H, Friede H, Paulin G, Lilja J, Rautio J, Andersen M, Åbyholm F, Lohmander A, Shaw W, Mølsted K, Heliövaara A, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Whitby D, Leonard A, Neovius E, Elander A, Willadsen E, Bannister RP, Bradbury E, Henningsson G, Persson C, Eyres P, Emborg B, Kisling-Møller M, Küseler A, Granhof Black B, Schöps A, Bau A, Boers M, Andersen HS, Jeppesen K, Marxen D, Paaso M, Hölttä E, Alaluusua S, Turunen L, Humerinta K, Elfving-Little U, Tørdal IB, Kjøll L, Aukner R, Hide Ø, Feragen KB, Rønning E, Skaare P, Brinck E, Semmingsen AM, Lindberg N, Bowden M, Davies J, Mooney J, Bellardie H, Schofield N, Nyberg J, Lundberg M, Karsten AL, Larson M, Holmefjord A, Reisæter S, Pedersen NH, Rasmussen T, Tindlund R, Sæle P, Blomhoff R, Jacobsen G, Havstam C, Rizell S, Enocson L, Hagberg C, Najar Chalien M, Paganini A, Lundeborg I, Marcusson A, Mjönes AB, Gustavsson A, Hayden C, McAleer E, Slevan E, Gregg T, Worthington H
J Plast Surg Hand Surg 2017 Feb;51(1):2-13. doi: 10.1080/2000656X.2016.1263202. PMID: 28218559
Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 2. Surgical results.
Rautio J, Andersen M, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Åbyholm F, Whitby D, Leonard A, Lilja J, Neovius E, Elander A, Heliövaara A, Eyres P, Semb G
J Plast Surg Hand Surg 2017 Feb;51(1):14-20. doi: 10.1080/2000656X.2016.1254646. PMID: 28218552
Impact of primary palatoplasty on the maxillomandibular sagittal relationship in patients with unilateral cleft lip and palate: a systematic review and meta-analysis.
Bichara LM, Araújo RC, Flores-Mir C, Normando D
Int J Oral Maxillofac Surg 2015 Jan;44(1):50-6. Epub 2014 Sep 10 doi: 10.1016/j.ijom.2014.08.004. PMID: 25217008
Comparison of three incisions to repair complete unilateral cleft lip.
Gosla Reddy S, Reddy RR, Bronkhorst EM, Prasad R, Kuijpers Jagtman AM, Bergé S
Plast Reconstr Surg 2010 Apr;125(4):1208-1216. doi: 10.1097/PRS.0b013e3181d45143. PMID: 20335871

Prognosis

Piriform Rim Asymmetry in Unilateral Cleft Lip and Palate Patients Before Orthognathic Surgery.
Ritto FG, Mealy T, Canellas JV, Padwa BL, Smith KS
J Oral Maxillofac Surg 2023 Nov;81(11):1344-1352. Epub 2023 Aug 9 doi: 10.1016/j.joms.2023.08.003. PMID: 37640235
Long-Term Results of the Murawski Unilateral Cleft Lip Repair.
Murawski EL, Gawrych EH, Cutting CB, Sifakis ED, Wang Q, Tao Y
Plast Reconstr Surg 2022 Feb 1;149(2):254e-260e. doi: 10.1097/PRS.0000000000008788. PMID: 35077424
Outcome of Patients with Complete Unilateral Cleft Lip and Palate: 20-Year Follow-Up of a Treatment Protocol.
Pai BCJ, Hung YT, Wang RSH, Lo LJ
Plast Reconstr Surg 2019 Feb;143(2):359e-367e. doi: 10.1097/PRS.0000000000005216. PMID: 30531628
A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
Semb G, Enemark H, Friede H, Paulin G, Lilja J, Rautio J, Andersen M, Åbyholm F, Lohmander A, Shaw W, Mølsted K, Heliövaara A, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Whitby D, Leonard A, Neovius E, Elander A, Willadsen E, Bannister RP, Bradbury E, Henningsson G, Persson C, Eyres P, Emborg B, Kisling-Møller M, Küseler A, Granhof Black B, Schöps A, Bau A, Boers M, Andersen HS, Jeppesen K, Marxen D, Paaso M, Hölttä E, Alaluusua S, Turunen L, Humerinta K, Elfving-Little U, Tørdal IB, Kjøll L, Aukner R, Hide Ø, Feragen KB, Rønning E, Skaare P, Brinck E, Semmingsen AM, Lindberg N, Bowden M, Davies J, Mooney J, Bellardie H, Schofield N, Nyberg J, Lundberg M, Karsten AL, Larson M, Holmefjord A, Reisæter S, Pedersen NH, Rasmussen T, Tindlund R, Sæle P, Blomhoff R, Jacobsen G, Havstam C, Rizell S, Enocson L, Hagberg C, Najar Chalien M, Paganini A, Lundeborg I, Marcusson A, Mjönes AB, Gustavsson A, Hayden C, McAleer E, Slevan E, Gregg T, Worthington H
J Plast Surg Hand Surg 2017 Feb;51(1):2-13. doi: 10.1080/2000656X.2016.1263202. PMID: 28218559
Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 2. Surgical results.
Rautio J, Andersen M, Bolund S, Hukki J, Vindenes H, Davenport P, Arctander K, Larson O, Berggren A, Åbyholm F, Whitby D, Leonard A, Lilja J, Neovius E, Elander A, Heliövaara A, Eyres P, Semb G
J Plast Surg Hand Surg 2017 Feb;51(1):14-20. doi: 10.1080/2000656X.2016.1254646. PMID: 28218552

Clinical prediction guides

Piriform Rim Asymmetry in Unilateral Cleft Lip and Palate Patients Before Orthognathic Surgery.
Ritto FG, Mealy T, Canellas JV, Padwa BL, Smith KS
J Oral Maxillofac Surg 2023 Nov;81(11):1344-1352. Epub 2023 Aug 9 doi: 10.1016/j.joms.2023.08.003. PMID: 37640235
The Melbourne Classification of the Complete Unilateral Cleft Lip Based on Hypoplasia.
Van Slyke AC, Chong DK
J Craniofac Surg 2022 Mar-Apr 01;33(2):380-384. doi: 10.1097/SCS.0000000000008277. PMID: 35385902Free PMC Article
Final Posttreatment Occlusion in Patients With Unilateral Cleft Lip and Palate.
Staudt CB, Bollhalder J, Eichenberger M, La Scala G, Herzog G, Wiedemeier DB, Antonarakis GS
Cleft Palate Craniofac J 2022 Jul;59(7):899-909. Epub 2021 Jul 8 doi: 10.1177/10556656211028506. PMID: 34235980Free PMC Article
The unilateral cleft lip repair.
Grewal JS, Yanik SC, Strohl-Bryan AM, Tatum SA
Am J Otolaryngol 2021 May-Jun;42(3):102908. Epub 2021 Jan 13 doi: 10.1016/j.amjoto.2021.102908. PMID: 33508593
Tooth agenesis patterns in unilateral cleft lip and palate in humans.
Bartzela TN, Carels CE, Bronkhorst EM, Kuijpers-Jagtman AM
Arch Oral Biol 2013 Jun;58(6):596-602. Epub 2013 Jan 5 doi: 10.1016/j.archoralbio.2012.12.007. PMID: 23295124

Recent systematic reviews

Effectiveness of pre-alveolar bone graft orthodontics for patients with non-syndromic complete unilateral cleft lip, alveolus and palate: A systematic review and meta-analysis.
Thiruvenkatachari B, Chakkaravarthi S, Prathap M, Naveed N, Bhuvaraghan A
Orthod Craniofac Res 2024 Jun;27 Suppl 1:90-99. Epub 2023 Dec 18 doi: 10.1111/ocr.12744. PMID: 38108550
Early or delayed palatoplasty in complete unilateral cleft lip and palate patients? A systematic review of the effects on maxillary growth.
Salgado KR, Wendt AR, Fernandes Fagundes NC, Maia LC, Normando D, Leão PB
J Craniomaxillofac Surg 2019 Nov;47(11):1690-1698. Epub 2019 Jul 3 doi: 10.1016/j.jcms.2019.06.017. PMID: 31677987
Impact of primary palatoplasty on the maxillomandibular sagittal relationship in patients with unilateral cleft lip and palate: a systematic review and meta-analysis.
Bichara LM, Araújo RC, Flores-Mir C, Normando D
Int J Oral Maxillofac Surg 2015 Jan;44(1):50-6. Epub 2014 Sep 10 doi: 10.1016/j.ijom.2014.08.004. PMID: 25217008

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...