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Cutaneous horn

MedGen UID:
508356
•Concept ID:
C0085664
•
Acquired Abnormality
Synonym: Cornu cutaneum
SNOMED CT: Cornu cutaneum (49417009); Cutaneous horn (403871001); Cornu cutaneum (403871001); Cutaneous horn (49417009)
 
HPO: HP:0033510

Definition

A cutaneous horn is a keratinized non-malignant protrusion on the surface of the skin. Diagnosis is established by biopsy of the horn and biopsy of the horn and the underlying skin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous horn

Professional guidelines

PubMed

Managing actinic keratosis in primary care.
Salmon N, Tidman MJ
Practitioner 2016 Oct;260(1797):25-9. PMID: 29016090
Drug targets of migraine and neuropathy: treatment of hyperexcitability.
Vécsei L, Majláth Z, Balog A, Tajti J
CNS Neurol Disord Drug Targets 2015;14(5):664-76. doi: 10.2174/1871527314666150429114040. PMID: 25921739
Central sensitisation and cutaneous allodynia in migraine: implications for treatment.
Landy S, Rice K, Lobo B
CNS Drugs 2004;18(6):337-42. doi: 10.2165/00023210-200418060-00001. PMID: 15089101

Recent clinical studies

Etiology

Cutaneous Horn of the Eyelid in 13 Cases.
Pointdujour-Lim R, Marous MR, Satija CE, Douglass AM, Eagle RC Jr, Shields JA, Shields CL
Ophthalmic Plast Reconstr Surg 2017 Jul/Aug;33(4):233-236. doi: 10.1097/IOP.0000000000000816. PMID: 27811637
Verrucous carcinoma masquerading as a giant fibroepithelial polyp.
Mercer SE, Khalil D, Emanuel PO, Goldenberg G
Int J Surg Pathol 2010 Oct;18(5):347-51. Epub 2010 Jul 28 doi: 10.1177/1066896910377786. PMID: 20667928
Cutaneous horn: a retrospective histopathological study of 222 cases.
Mantese SA, Diogo PM, Rocha A, Berbert AL, Ferreira AK, Ferreira TC
An Bras Dermatol 2010 Mar-Apr;85(2):157-63. doi: 10.1590/s0365-05962010000200005. PMID: 20520930
Cutaneous horns of the eyelid: a clinicopathological study of 48 cases.
Mencía-Gutiérrez E, Gutiérrez-Díaz E, Redondo-Marcos I, Ricoy JR, García-Torre JP
J Cutan Pathol 2004 Sep;31(8):539-43. doi: 10.1111/j.0303-6987.2004.00226.x. PMID: 15268708
A histopathological study of 643 cutaneous horns.
Yu RC, Pryce DW, Macfarlane AW, Stewart TW
Br J Dermatol 1991 May;124(5):449-52. doi: 10.1111/j.1365-2133.1991.tb00624.x. PMID: 2039721

Diagnosis

Cutaneous horn due to cutaneous squamous cell carcinoma.
Zhang LW, Chen T
Med J Aust 2022 Dec 12;217(11):586. Epub 2022 Nov 15 doi: 10.5694/mja2.51781. PMID: 36379697
Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956
Giant Cutaneous Horn Arising in an Epidermal Nevus.
Cardis MA, Kirkorian AY
Pediatr Dermatol 2017 Sep;34(5):e290-e291. Epub 2017 Aug 7 doi: 10.1111/pde.13221. PMID: 28783212
Cutaneous Horn of the Eyelid in 13 Cases.
Pointdujour-Lim R, Marous MR, Satija CE, Douglass AM, Eagle RC Jr, Shields JA, Shields CL
Ophthalmic Plast Reconstr Surg 2017 Jul/Aug;33(4):233-236. doi: 10.1097/IOP.0000000000000816. PMID: 27811637
Extragingival pyogenic granuloma.
Patil K, Mahima VG, Lahari K
Indian J Dent Res 2006 Oct-Dec;17(4):199-202. doi: 10.4103/0970-9290.29864. PMID: 17217217

Therapy

Renal cell carcinoma presenting as a cutaneous horn and nodules on the gingiva and scalp.
Georgy JT, Mathuram AJ, George AA, Chandramohan J
BMJ Case Rep 2017 Aug 18;2017 doi: 10.1136/bcr-2017-220913. PMID: 28824000Free PMC Article
Penile cutaneous horn over long standing radiation dermatitis.
Nayyar R, Singh P, Seth A
J Postgrad Med 2009 Oct-Dec;55(4):287. doi: 10.4103/0022-3859.58937. PMID: 20083880
Expression of stratum corneum chymotryptic enzyme in ichthyoses and squamoproliferative processes.
Johnson B, Horn T, Sander C, Kohler S, R Smoller B
J Cutan Pathol 2003 Jul;30(6):358-62. doi: 10.1034/j.1600-0560.2003.00070.x. PMID: 12834483
Penile verrucous carcinoma.
Yeager JK, Findlay RF, McAleer IM
Arch Dermatol 1990 Sep;126(9):1208-10. PMID: 2396837

Prognosis

Renal cell carcinoma presenting as a cutaneous horn and nodules on the gingiva and scalp.
Georgy JT, Mathuram AJ, George AA, Chandramohan J
BMJ Case Rep 2017 Aug 18;2017 doi: 10.1136/bcr-2017-220913. PMID: 28824000Free PMC Article
Giant Cutaneous Horn Arising in an Epidermal Nevus.
Cardis MA, Kirkorian AY
Pediatr Dermatol 2017 Sep;34(5):e290-e291. Epub 2017 Aug 7 doi: 10.1111/pde.13221. PMID: 28783212
Claw foot A case report.
Innocenti A, Ciancio F, Taverna C, Tanini S, Portincasa A, Parisi D, Innocenti M, De Giorgi V
Ann Ital Chir 2017;88:368-370. PMID: 28632148
A prospective, multicentre study of malignant and premalignant lesions at the base of periocular cutaneous horns.
Tambe K, Reuser TT, Sampath RG, Burns J, Ahluwalia H, Bowyer JD, Kumar B, Sandramouli S
Orbit 2012 Dec;31(6):404-7. doi: 10.3109/01676830.2012.689080. PMID: 23231064
Cutaneous horn of eyelid.
Thappa DM, Laxmisha C
Indian Pediatr 2004 Feb;41(2):195. PMID: 15004310

Clinical prediction guides

Claw foot A case report.
Innocenti A, Ciancio F, Taverna C, Tanini S, Portincasa A, Parisi D, Innocenti M, De Giorgi V
Ann Ital Chir 2017;88:368-370. PMID: 28632148
Onychomatricoma with misleading features.
Fayol J, Baran R, Perrin C, Labrousse F
Acta Derm Venereol 2000 Sep-Oct;80(5):370-2. doi: 10.1080/000155500459330. PMID: 11200837
Onychomatricoma: clinical and histopathologic findings in 12 cases.
Perrin C, Goettmann S, Baran R
J Am Acad Dermatol 1998 Oct;39(4 Pt 1):560-4. doi: 10.1016/s0190-9622(98)70004-0. PMID: 9777762
Trichilemmal horn: case presentation and literature review.
DiMaio DJ, Cohen PR
J Am Acad Dermatol 1998 Aug;39(2 Pt 2):368-71. doi: 10.1016/s0190-9622(98)70393-7. PMID: 9703156
Perforating pilomatricoma.
Uchiyama N, Shindo Y, Saida T
J Cutan Pathol 1986 Aug;13(4):312-8. doi: 10.1111/j.1600-0560.1986.tb01528.x. PMID: 3771876

Recent systematic reviews

Zebras in Foreskin Dermatopathology: A Review.
Alhatem A, Patel N, Lambert WC, Heller DS
J Low Genit Tract Dis 2019 Jul;23(3):235-240. doi: 10.1097/LGT.0000000000000478. PMID: 31149956

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