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Isolated focal cortical dysplasia type I

MedGen UID:
1843077
•Concept ID:
C5679772
•
Congenital Abnormality
Synonyms: FCD type I; isolated focal cortical dysplasia type I
 
Monarch Initiative: MONDO:0017095
Orphanet: ORPHA268961

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIsolated focal cortical dysplasia type I

Professional guidelines

PubMed

Neuropathological work-up of focal cortical dysplasias using the new ILAE consensus classification system - practical guideline article invited by the Euro-CNS Research Committee.
Blümcke I, Mühlebner A
Clin Neuropathol 2011 Jul-Aug;30(4):164-77. doi: 10.5414/np300398. PMID: 21726501

Recent clinical studies

Etiology

The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D.
Wang DD, Katoch M, Jabari S, Blumcke I, Blumenthal DB, Lu DH, Coras R, Wang YJ, Shi J, Zhou WJ, Kobow K, Piao YS
Acta Neuropathol Commun 2023 Aug 9;11(1):129. doi: 10.1186/s40478-023-01618-6. PMID: 37559109Free PMC Article
Focal cortical dysplasia: Updates.
Pinheiro J, Honavar M
Indian J Pathol Microbiol 2022 May;65(Supplement):S189-S197. doi: 10.4103/ijpm.ijpm_1226_21. PMID: 35562149
Temporal lobe epilepsy and focal cortical dysplasia in children: A tip to find the abnormality.
Bartolini L, Whitehead MT, Ho CY, Sepeta LN, Oluigbo CO, Havens K, Freilich ER, Schreiber JM, Gaillard WD
Epilepsia 2017 Jan;58(1):113-122. Epub 2016 Nov 16 doi: 10.1111/epi.13615. PMID: 27864929
Failure to detect human papillomavirus in focal cortical dysplasia type IIb.
Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ
Ann Neurol 2015 Jul;78(1):63-7. Epub 2015 May 4 doi: 10.1002/ana.24422. PMID: 25893423
Infantile tauopathies: Hemimegalencephaly; tuberous sclerosis complex; focal cortical dysplasia 2; ganglioglioma.
Sarnat HB, Flores-Sarnat L
Brain Dev 2015 Jun;37(6):553-62. Epub 2014 Oct 19 doi: 10.1016/j.braindev.2014.08.010. PMID: 25451314

Diagnosis

The specific DNA methylation landscape in focal cortical dysplasia ILAE type 3D.
Wang DD, Katoch M, Jabari S, Blumcke I, Blumenthal DB, Lu DH, Coras R, Wang YJ, Shi J, Zhou WJ, Kobow K, Piao YS
Acta Neuropathol Commun 2023 Aug 9;11(1):129. doi: 10.1186/s40478-023-01618-6. PMID: 37559109Free PMC Article
Ultra-Low Level Somatic Mutations and Structural Variations in Focal Cortical Dysplasia Type II.
Kim JH, Park JH, Lee J, Park JW, Kim HJ, Chang WS, Kim DS, Ju YS, Aronica E, Lee JH
Ann Neurol 2023 Jun;93(6):1082-1093. Epub 2023 Feb 8 doi: 10.1002/ana.26609. PMID: 36700525
Focal cortical dysplasia: Updates.
Pinheiro J, Honavar M
Indian J Pathol Microbiol 2022 May;65(Supplement):S189-S197. doi: 10.4103/ijpm.ijpm_1226_21. PMID: 35562149
Focal cortical dysplasia: Molecular disturbances and clinicopathological classification (Review).
Siedlecka M, Grajkowska W, Galus R, Dembowska-Bagińska B, Jóźwiak J
Int J Mol Med 2016 Nov;38(5):1327-1337. Epub 2016 Sep 29 doi: 10.3892/ijmm.2016.2760. PMID: 28025990
Surgical treatment of epilepsy associated with cortical dysplasia: 2012 update.
Hauptman JS, Mathern GW
Epilepsia 2012 Sep;53 Suppl 4:98-104. doi: 10.1111/j.1528-1167.2012.03619.x. PMID: 22946727

Therapy

Significant Therapeutic Effects of Adult Human Neural Stem Cells for Spinal Cord Injury Are Mediated by Monocyte Chemoattractant Protein-1 (MCP-1).
Kim CK, Won JS, An JY, Lee HJ, Nam AJ, Nam H, Lee JY, Lee KH, Lee SH, Joo KM
Int J Mol Sci 2022 Apr 12;23(8) doi: 10.3390/ijms23084267. PMID: 35457084Free PMC Article
Surgical outcome and predictive factors of epilepsy surgery in pediatric isolated focal cortical dysplasia.
Choi SA, Kim SY, Kim H, Kim WJ, Kim H, Hwang H, Choi JE, Lim BC, Chae JH, Chong S, Lee JY, Phi JH, Kim SK, Wang KC, Kim KJ
Epilepsy Res 2018 Jan;139:54-59. Epub 2017 Nov 27 doi: 10.1016/j.eplepsyres.2017.11.012. PMID: 29197666
Comparison of electrocorticographic patterns with focal cortical dysplasia types in children with epilepsy.
Korsakova MB, Kozlova AB, Arkhipova NA, Shishkina LV, Vorob'ev AN, Sorokin VS, Masherov EL, Melikyan AG
Zh Vopr Neirokhir Im N N Burdenko 2015;79(5):19-27. doi: 10.17116/neiro201579519-27. PMID: 26528609
Hot water epilepsy and focal malformation of the parietal cortex development.
Grosso S, Farnetani MA, Francione S, Galluzzi P, Vatti G, Cordelli DM, Morgese G, Balestri P
Brain Dev 2004 Oct;26(7):490-3. doi: 10.1016/j.braindev.2003.12.004. PMID: 15351089

Prognosis

Surgical outcome and predictive factors of epilepsy surgery in pediatric isolated focal cortical dysplasia.
Choi SA, Kim SY, Kim H, Kim WJ, Kim H, Hwang H, Choi JE, Lim BC, Chae JH, Chong S, Lee JY, Phi JH, Kim SK, Wang KC, Kim KJ
Epilepsy Res 2018 Jan;139:54-59. Epub 2017 Nov 27 doi: 10.1016/j.eplepsyres.2017.11.012. PMID: 29197666
Post-surgical outcome for epilepsy associated with type I focal cortical dysplasia subtypes.
Simpson SL, Prayson RA
Mod Pathol 2014 Nov;27(11):1455-60. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.64. PMID: 24743217
Comparison of MRI features and surgical outcome among the subtypes of focal cortical dysplasia.
Kim DW, Kim S, Park SH, Chung CK, Lee SK
Seizure 2012 Dec;21(10):789-94. Epub 2012 Oct 4 doi: 10.1016/j.seizure.2012.09.006. PMID: 23040369
A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia.
Rowland NC, Englot DJ, Cage TA, Sughrue ME, Barbaro NM, Chang EF
J Neurosurg 2012 May;116(5):1035-41. Epub 2012 Feb 10 doi: 10.3171/2012.1.JNS111105. PMID: 22324422
Electro-clinical and imaging characteristics of focal cortical dysplasia: correlation with pathological subtypes.
Widdess-Walsh P, Kellinghaus C, Jeha L, Kotagal P, Prayson R, Bingaman W, Najm IM
Epilepsy Res 2005 Oct-Nov;67(1-2):25-33. Epub 2005 Sep 21 doi: 10.1016/j.eplepsyres.2005.07.013. PMID: 16181772

Clinical prediction guides

An Investigation into the Correlation of Scalp Electrophysiological Findings with Preoperative Clinical and Imaging Findings in Patients with Focal Cortical Dysplasia.
Gurkan ZM, Kapar O, Yeni SN, Bilgic B, Gurses C
Turk Neurosurg 2022;32(5):802-811. doi: 10.5137/1019-5149.JTN.36547-21.2. PMID: 35713255
Surgical outcome and predictive factors of epilepsy surgery in pediatric isolated focal cortical dysplasia.
Choi SA, Kim SY, Kim H, Kim WJ, Kim H, Hwang H, Choi JE, Lim BC, Chae JH, Chong S, Lee JY, Phi JH, Kim SK, Wang KC, Kim KJ
Epilepsy Res 2018 Jan;139:54-59. Epub 2017 Nov 27 doi: 10.1016/j.eplepsyres.2017.11.012. PMID: 29197666
Comparison of electrocorticographic patterns with focal cortical dysplasia types in children with epilepsy.
Korsakova MB, Kozlova AB, Arkhipova NA, Shishkina LV, Vorob'ev AN, Sorokin VS, Masherov EL, Melikyan AG
Zh Vopr Neirokhir Im N N Burdenko 2015;79(5):19-27. doi: 10.17116/neiro201579519-27. PMID: 26528609
Post-surgical outcome for epilepsy associated with type I focal cortical dysplasia subtypes.
Simpson SL, Prayson RA
Mod Pathol 2014 Nov;27(11):1455-60. Epub 2014 Apr 18 doi: 10.1038/modpathol.2014.64. PMID: 24743217
Type I focal cortical dysplasia: surgical outcome is related to histopathology.
Tassi L, Garbelli R, Colombo N, Bramerio M, Lo Russo G, Deleo F, Milesi G, Spreafico R
Epileptic Disord 2010 Sep;12(3):181-91. Epub 2010 Jul 27 doi: 10.1684/epd.2010.0327. PMID: 20659869

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