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Increased urine phenylacetylglutamine level

MedGen UID:
1842130
•Concept ID:
C5826737
•
Finding
HPO: HP:0034887

Definition

The concentration of phenylacetylglutamine in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urine phenylacetylglutamine level

Recent clinical studies

Etiology

In older women, a high-protein diet including animal-sourced foods did not impact serum levels and urinary excretion of trimethylamine-N-oxide.
Dahl WJ, Hung WL, Ford AL, Suh JH, Auger J, Nagulesapillai V, Wang Y
Nutr Res 2020 Jun;78:72-81. Epub 2020 May 17 doi: 10.1016/j.nutres.2020.05.004. PMID: 32544852
Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia.
Stravitz RT, Gottfried M, Durkalski V, Fontana RJ, Hanje AJ, Koch D, Hameed B, Ganger D, Subramanian RM, Bukofzer S, Ravis WR, Clasen K, Sherker A, Little L, Lee WM; Acute Liver Failure Study Group
Hepatology 2018 Mar;67(3):1003-1013. Epub 2018 Jan 30 doi: 10.1002/hep.29621. PMID: 29080224Free PMC Article
Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism.
Collino S, Montoliu I, Martin FP, Scherer M, Mari D, Salvioli S, Bucci L, Ostan R, Monti D, Biagi E, Brigidi P, Franceschi C, Rezzi S
PLoS One 2013;8(3):e56564. Epub 2013 Mar 6 doi: 10.1371/journal.pone.0056564. PMID: 23483888Free PMC Article

Diagnosis

Urinary phenylethylamine metabolites as potential markers for sports drug testing purposes.
Krombholz S, Thomas A, Piper T, Lagojda A, Kühne D, Thevis M
Biomed Chromatogr 2022 Feb;36(2):e5274. Epub 2021 Nov 17 doi: 10.1002/bmc.5274. PMID: 34729800

Therapy

In older women, a high-protein diet including animal-sourced foods did not impact serum levels and urinary excretion of trimethylamine-N-oxide.
Dahl WJ, Hung WL, Ford AL, Suh JH, Auger J, Nagulesapillai V, Wang Y
Nutr Res 2020 Jun;78:72-81. Epub 2020 May 17 doi: 10.1016/j.nutres.2020.05.004. PMID: 32544852
Two apples a day modulate human:microbiome co-metabolic processing of polyphenols, tyrosine and tryptophan.
Ulaszewska MM, Koutsos A, Trošt K, Stanstrup J, Garcia-Aloy M, Scholz M, Fava F, Natella F, Scaccini C, Vrhovsek U, Tuohy K, Lovegrove J, Mattivi F
Eur J Nutr 2020 Dec;59(8):3691-3714. Epub 2020 Feb 26 doi: 10.1007/s00394-020-02201-8. PMID: 32103319
Safety, tolerability, and pharmacokinetics of l-ornithine phenylacetate in patients with acute liver injury/failure and hyperammonemia.
Stravitz RT, Gottfried M, Durkalski V, Fontana RJ, Hanje AJ, Koch D, Hameed B, Ganger D, Subramanian RM, Bukofzer S, Ravis WR, Clasen K, Sherker A, Little L, Lee WM; Acute Liver Failure Study Group
Hepatology 2018 Mar;67(3):1003-1013. Epub 2018 Jan 30 doi: 10.1002/hep.29621. PMID: 29080224Free PMC Article
A phase I and pharmacokinetic study of intravenous phenylacetate in patients with cancer.
Thibault A, Cooper MR, Figg WD, Venzon DJ, Sartor AO, Tompkins AC, Weinberger MS, Headlee DJ, McCall NA, Samid D
Cancer Res 1994 Apr 1;54(7):1690-4. PMID: 8137283

Clinical prediction guides

Urinary phenylethylamine metabolites as potential markers for sports drug testing purposes.
Krombholz S, Thomas A, Piper T, Lagojda A, Kühne D, Thevis M
Biomed Chromatogr 2022 Feb;36(2):e5274. Epub 2021 Nov 17 doi: 10.1002/bmc.5274. PMID: 34729800

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