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Interstitial dermal edema

MedGen UID:
1841908
•Concept ID:
C5826816
•
Pathologic Function
HPO: HP:0034989

Definition

Accumulation of fluid in the interstitial spaces of the skin. This finding can be appreciated my microscopic examination of a skin biopsy. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInterstitial dermal edema

Professional guidelines

PubMed

Topical steroid is effective for the treatment of phimosis in young children.
Sookpotarom P, Porncharoenpong S, Vejchapipat P
J Med Assoc Thai 2010 Jan;93(1):77-83. PMID: 20196415

Recent clinical studies

Etiology

Prediction of breast cancer-related lymphedema by dermal backflow detected with near-infrared fluorescence lymphatic imaging.
Aldrich MB, Rasmussen JC, DeSnyder SM, Woodward WA, Chan W, Sevick-Muraca EM, Mittendorf EA, Smith BD, Stauder MC, Strom EA, Perkins GH, Hoffman KE, Mitchell MP, Barcenas CH, Isales LE, Shaitelman SF
Breast Cancer Res Treat 2022 Aug;195(1):33-41. Epub 2022 Jul 10 doi: 10.1007/s10549-022-06667-4. PMID: 35816269Free PMC Article
The Histopathology of Urticaria Revisited-Clinical Pathological Study.
Barzilai A, Sagi L, Baum S, Trau H, Schvimer M, Barshack I, Solomon M
Am J Dermatopathol 2017 Oct;39(10):753-759. doi: 10.1097/DAD.0000000000000786. PMID: 28858880
Neutrophilic Figurate Erythema.
Wu YH, Hsiao PF
Am J Dermatopathol 2017 May;39(5):344-350. doi: 10.1097/DAD.0000000000000723. PMID: 28426486
A review of the local pathophysiologic bases of burn wound progression.
Shupp JW, Nasabzadeh TJ, Rosenthal DS, Jordan MH, Fidler P, Jeng JC
J Burn Care Res 2010 Nov-Dec;31(6):849-73. doi: 10.1097/BCR.0b013e3181f93571. PMID: 21105319
Neutrophilic urticarial dermatosis: a variant of neutrophilic urticaria strongly associated with systemic disease. Report of 9 new cases and review of the literature.
Kieffer C, Cribier B, Lipsker D
Medicine (Baltimore) 2009 Jan;88(1):23-31. doi: 10.1097/MD.0b013e3181943f5e. PMID: 19352297

Diagnosis

Neutrophilic Urticarial Dermatosis.
Orakwue A, Bray J, Comfere N, Sokumbi O
Dermatol Clin 2024 Apr;42(2):219-229. Epub 2023 Sep 15 doi: 10.1016/j.det.2023.08.009. PMID: 38423683
Prediction of breast cancer-related lymphedema by dermal backflow detected with near-infrared fluorescence lymphatic imaging.
Aldrich MB, Rasmussen JC, DeSnyder SM, Woodward WA, Chan W, Sevick-Muraca EM, Mittendorf EA, Smith BD, Stauder MC, Strom EA, Perkins GH, Hoffman KE, Mitchell MP, Barcenas CH, Isales LE, Shaitelman SF
Breast Cancer Res Treat 2022 Aug;195(1):33-41. Epub 2022 Jul 10 doi: 10.1007/s10549-022-06667-4. PMID: 35816269Free PMC Article
Dermal Interstitial Alterations in Patients With Heart Failure and Reduced Ejection Fraction: A Potential Contributor to Fluid Accumulation?
Nijst P, Olinevich M, Hilkens P, Martens P, Dupont M, Tang WHW, Lambrichts I, Noben JP, Mullens W
Circ Heart Fail 2018 Jul;11(7):e004763. doi: 10.1161/CIRCHEARTFAILURE.117.004763. PMID: 30002114
Cold-Induced Dermatoses: Case Report and Review of Literature.
Saenz Ibarra B, Meeker J, Jalali O, Lynch MC
Am J Dermatopathol 2018 Apr;40(4):291-294. doi: 10.1097/DAD.0000000000001018. PMID: 28984694
Neutrophilic Figurate Erythema.
Wu YH, Hsiao PF
Am J Dermatopathol 2017 May;39(5):344-350. doi: 10.1097/DAD.0000000000000723. PMID: 28426486

Therapy

Dermal Interstitial Alterations in Patients With Heart Failure and Reduced Ejection Fraction: A Potential Contributor to Fluid Accumulation?
Nijst P, Olinevich M, Hilkens P, Martens P, Dupont M, Tang WHW, Lambrichts I, Noben JP, Mullens W
Circ Heart Fail 2018 Jul;11(7):e004763. doi: 10.1161/CIRCHEARTFAILURE.117.004763. PMID: 30002114
Neutrophilic Figurate Erythema.
Wu YH, Hsiao PF
Am J Dermatopathol 2017 May;39(5):344-350. doi: 10.1097/DAD.0000000000000723. PMID: 28426486
Therapeutic approach to chronic venous insufficiency and its complications: place of Daflon 500 mg.
Bergan JJ, Schmid-Schönbein GW, Takase S
Angiology 2001 Aug;52 Suppl 1:S43-7. doi: 10.1177/0003319701052001S06. PMID: 11510596
Metal toxicity and the respiratory tract.
Nemery B
Eur Respir J 1990 Feb;3(2):202-19. PMID: 2178966
Medical use of dimethyl sulfoxide (DMSO).
Swanson BN
Rev Clin Basic Pharm 1985 Jan-Jun;5(1-2):1-33. PMID: 3916302

Prognosis

Prediction of breast cancer-related lymphedema by dermal backflow detected with near-infrared fluorescence lymphatic imaging.
Aldrich MB, Rasmussen JC, DeSnyder SM, Woodward WA, Chan W, Sevick-Muraca EM, Mittendorf EA, Smith BD, Stauder MC, Strom EA, Perkins GH, Hoffman KE, Mitchell MP, Barcenas CH, Isales LE, Shaitelman SF
Breast Cancer Res Treat 2022 Aug;195(1):33-41. Epub 2022 Jul 10 doi: 10.1007/s10549-022-06667-4. PMID: 35816269Free PMC Article
Neutrophilic Figurate Erythema.
Wu YH, Hsiao PF
Am J Dermatopathol 2017 May;39(5):344-350. doi: 10.1097/DAD.0000000000000723. PMID: 28426486
Contributions of SPECT/CT imaging to the lymphoscintigraphic investigations of the lower limb lymphedema.
Baulieu F, Bourgeois P, Maruani A, Belgrado JP, Tauveron V, Lorette G, Vaillant L
Lymphology 2013 Sep;46(3):106-19. PMID: 24645534
Drug-induced hypersensitivity syndrome with superficial granulomatous dermatitis--a novel finding.
Fernando SL, Henderson CJ, O'Connor KS
Am J Dermatopathol 2009 Aug;31(6):611-3. doi: 10.1097/DAD.0b013e3181a18d64. PMID: 19590408
Ultrastructural changes elicited by a non-ablative wrinkle reduction laser.
Omi T, Kawana S, Sato S, Honda M
Lasers Surg Med 2003;32(1):46-9. doi: 10.1002/lsm.10119. PMID: 12516070

Clinical prediction guides

Dermal Interstitial Alterations in Patients With Heart Failure and Reduced Ejection Fraction: A Potential Contributor to Fluid Accumulation?
Nijst P, Olinevich M, Hilkens P, Martens P, Dupont M, Tang WHW, Lambrichts I, Noben JP, Mullens W
Circ Heart Fail 2018 Jul;11(7):e004763. doi: 10.1161/CIRCHEARTFAILURE.117.004763. PMID: 30002114
The Histopathology of Urticaria Revisited-Clinical Pathological Study.
Barzilai A, Sagi L, Baum S, Trau H, Schvimer M, Barshack I, Solomon M
Am J Dermatopathol 2017 Oct;39(10):753-759. doi: 10.1097/DAD.0000000000000786. PMID: 28858880
Neutrophilic Figurate Erythema.
Wu YH, Hsiao PF
Am J Dermatopathol 2017 May;39(5):344-350. doi: 10.1097/DAD.0000000000000723. PMID: 28426486
Therapeutic approach to chronic venous insufficiency and its complications: place of Daflon 500 mg.
Bergan JJ, Schmid-Schönbein GW, Takase S
Angiology 2001 Aug;52 Suppl 1:S43-7. doi: 10.1177/0003319701052001S06. PMID: 11510596
Metal toxicity and the respiratory tract.
Nemery B
Eur Respir J 1990 Feb;3(2):202-19. PMID: 2178966

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