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Abnormal keratinocyte morphology

MedGen UID:
1841684
•Concept ID:
C5826598
•
Finding
HPO: HP:0034702

Definition

Any structural anomaly of the keratinocyte. The keratinocyte is the major cell type of the epidermis and is responsible for generating the protective barrier. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal keratinocyte morphology

Professional guidelines

PubMed

STAT2/Caspase3 in the diagnosis and treatment of psoriasis.
Fu Z, He Y, Gao L, Tong X, Zhou L, Zeng J
Eur J Clin Invest 2023 Jun;53(6):e13959. Epub 2023 Feb 7 doi: 10.1111/eci.13959. PMID: 36708067
Mechanism of Oleogel-S10: A triterpene preparation for the treatment of epidermolysis bullosa.
Schwieger-Briel A, Ott H, Kiritsi D, Laszczyk-Lauer M, Bodemer C
Dermatol Ther 2019 Jul;32(4):e12983. Epub 2019 Jul 2 doi: 10.1111/dth.12983. PMID: 31168940Free PMC Article
Biologic Therapy for Atopic Dermatitis: Moving Beyond the Practice Parameter and Guidelines.
Boguniewicz M
J Allergy Clin Immunol Pract 2017 Nov-Dec;5(6):1477-1487. doi: 10.1016/j.jaip.2017.08.031. PMID: 29122151

Recent clinical studies

Etiology

Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis.
Zhou J, Liang G, Liu L, Feng S, Zheng Z, Wu Y, Chen X, Li X, Wang L, Wang L, Song Z
J Eur Acad Dermatol Venereol 2023 Nov;37(11):2336-2348. Epub 2023 Jul 3 doi: 10.1111/jdv.19256. PMID: 37326015
The cardiometabolic conditions of psoriatic disease.
Toussirot E, Gallais-Sérézal I, Aubin F
Front Immunol 2022;13:970371. Epub 2022 Sep 8 doi: 10.3389/fimmu.2022.970371. PMID: 36159785Free PMC Article
Pathophysiology of psoriasis: A review.
Yamanaka K, Yamamoto O, Honda T
J Dermatol 2021 Jun;48(6):722-731. Epub 2021 Apr 22 doi: 10.1111/1346-8138.15913. PMID: 33886133
Pustular psoriasis and related pustular skin diseases.
Bachelez H
Br J Dermatol 2018 Mar;178(3):614-618. Epub 2018 Jan 15 doi: 10.1111/bjd.16232. PMID: 29333670
Inherited ichthyoses/generalized Mendelian disorders of cornification.
Schmuth M, Martinz V, Janecke AR, Fauth C, Schossig A, Zschocke J, Gruber R
Eur J Hum Genet 2013 Feb;21(2):123-33. Epub 2012 Jun 27 doi: 10.1038/ejhg.2012.121. PMID: 22739337Free PMC Article

Diagnosis

Keratinocytes: An Enigmatic Factor in Atopic Dermatitis.
Das P, Mounika P, Yellurkar ML, Prasanna VS, Sarkar S, Velayutham R, Arumugam S
Cells 2022 May 19;11(10) doi: 10.3390/cells11101683. PMID: 35626720Free PMC Article
Clinical Features, Immunopathogenesis, and Therapeutic Strategies in Vitiligo.
Wang Y, Li S, Li C
Clin Rev Allergy Immunol 2021 Dec;61(3):299-323. Epub 2021 Jul 20 doi: 10.1007/s12016-021-08868-z. PMID: 34283349
Acalvaria.
Hawasli AH, Beaumont TL, Vogel TW, Woo AS, Leonard JR
J Neurosurg Pediatr 2014 Aug;14(2):200-2. Epub 2014 Jun 13 doi: 10.3171/2014.5.PEDS13688. PMID: 24926969
Tissue-engineered oral mucosa.
Moharamzadeh K, Colley H, Murdoch C, Hearnden V, Chai WL, Brook IM, Thornhill MH, Macneil S
J Dent Res 2012 Jul;91(7):642-50. Epub 2012 Jan 19 doi: 10.1177/0022034511435702. PMID: 22266525
Vitiligo.
Le Poole C, Boissy RE
Semin Cutan Med Surg 1997 Mar;16(1):3-14. doi: 10.1016/s1085-5629(97)80030-2. PMID: 9125760

Therapy

The cardiometabolic conditions of psoriatic disease.
Toussirot E, Gallais-Sérézal I, Aubin F
Front Immunol 2022;13:970371. Epub 2022 Sep 8 doi: 10.3389/fimmu.2022.970371. PMID: 36159785Free PMC Article
The Role of Autophagy in Skin Fibroblasts, Keratinocytes, Melanocytes, and Epidermal Stem Cells.
Jeong D, Qomaladewi NP, Lee J, Park SH, Cho JY
J Invest Dermatol 2020 Sep;140(9):1691-1697. doi: 10.1016/j.jid.2019.11.023. PMID: 32800183
Nutrition and Psoriasis.
Kanda N, Hoashi T, Saeki H
Int J Mol Sci 2020 Jul 29;21(15) doi: 10.3390/ijms21155405. PMID: 32751360Free PMC Article
Melasma pathogenesis: a review of the latest research, pathological findings, and investigational therapies.
Rajanala S, Maymone MBC, Vashi NA
Dermatol Online J 2019 Oct 15;25(10) PMID: 31735001
A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903.
Moosbrugger-Martinz V, Schmuth M, Dubrac S
Methods Mol Biol 2017;1559:91-106. doi: 10.1007/978-1-4939-6786-5_8. PMID: 28063040

Prognosis

Current Concepts on the Pathogenesis of Systemic Sclerosis.
Truchetet ME, Brembilla NC, Chizzolini C
Clin Rev Allergy Immunol 2023 Jun;64(3):262-283. Epub 2021 Sep 6 doi: 10.1007/s12016-021-08889-8. PMID: 34487318Free PMC Article
The cardiometabolic conditions of psoriatic disease.
Toussirot E, Gallais-Sérézal I, Aubin F
Front Immunol 2022;13:970371. Epub 2022 Sep 8 doi: 10.3389/fimmu.2022.970371. PMID: 36159785Free PMC Article
Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex.
Evtushenko NA, Beilin AK, Kosykh AV, Vorotelyak EA, Gurskaya NG
Int J Mol Sci 2021 Nov 18;22(22) doi: 10.3390/ijms222212446. PMID: 34830328Free PMC Article
Peeling off the genetics of atopic dermatitis-like congenital disorders.
Samuelov L, Sprecher E
J Allergy Clin Immunol 2014 Oct;134(4):808-15. doi: 10.1016/j.jaci.2014.07.061. PMID: 25282561
Griscelli syndrome.
Emanuel PO, Sternberg LJ, Phelps RG
Skinmed 2007 May-Jun;6(3):147-9. doi: 10.1111/j.1540-9740.2007.05783.x. PMID: 17483661

Clinical prediction guides

Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation.
Shou Y, Yang L, Yang Y, Xu J
Cell Death Dis 2021 Oct 27;12(11):1009. doi: 10.1038/s41419-021-04284-5. PMID: 34707088Free PMC Article
Aquaporin-3 in the epidermis: more than skin deep.
Bollag WB, Aitkens L, White J, Hyndman KA
Am J Physiol Cell Physiol 2020 Jun 1;318(6):C1144-C1153. Epub 2020 Apr 8 doi: 10.1152/ajpcell.00075.2020. PMID: 32267715Free PMC Article
Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation.
Thatikonda S, Pooladanda V, Sigalapalli DK, Godugu C
Cell Death Dis 2020 Jan 10;11(1):21. doi: 10.1038/s41419-019-2212-y. PMID: 31924750Free PMC Article
Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury.
Sangiovanni E, Fumagalli M, Pacchetti B, Piazza S, Magnavacca A, Khalilpour S, Melzi G, Martinelli G, Dell'Agli M
Phytother Res 2019 Aug;33(8):2083-2093. Epub 2019 Jun 27 doi: 10.1002/ptr.6400. PMID: 31250491
A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903.
Moosbrugger-Martinz V, Schmuth M, Dubrac S
Methods Mol Biol 2017;1559:91-106. doi: 10.1007/978-1-4939-6786-5_8. PMID: 28063040

Recent systematic reviews

Interplay Between Keratinocytes and Fibroblasts: A Systematic Review Providing a New Angle for Understanding Skin Fibrotic Disorders.
Russo B, Brembilla NC, Chizzolini C
Front Immunol 2020;11:648. Epub 2020 May 6 doi: 10.3389/fimmu.2020.00648. PMID: 32477322Free PMC Article

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