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Conjunctival Reactive Lymphoid Hyperplasia

MedGen UID:
1782661
•Concept ID:
C5446512
•
Pathologic Function

Definition

A polyclonal proliferation of lymphoid tissue in the conjunctiva that typically occurs in young adults. It usually presents as a unilateral, red or orange, painless swelling and is probably caused by chronic antigen stimulation. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Reactive Lymphoid Hyperplasia

Recent clinical studies

Etiology

Benign reactive lymphoid hyperplasia of the conjunctiva in childhood.
AlAkeely AG, Alkatan HM, Alsuhaibani AH, AlKhalidi H, Safieh LA, Coupland SE, Edward DP
Br J Ophthalmol 2017 Jul;101(7):933-939. Epub 2016 Nov 29 doi: 10.1136/bjophthalmol-2016-309030. PMID: 27899370
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Paediatric and adolescent elevated conjunctival lesions in the plical area: lymphoma or reactive lymphoid hyperplasia?
Beykin G, Pe'er J, Amir G, Frenkel S
Br J Ophthalmol 2014 May;98(5):645-50. Epub 2013 Oct 25 doi: 10.1136/bjophthalmol-2013-303527. PMID: 24162623
Ocular adnexal reactive lymphoid hyperplasia in children.
Al-Mujaini A, Wali U, Ganesh A, Al-Hadabi I, Burney I
Middle East Afr J Ophthalmol 2012 Oct;19(4):406-9. doi: 10.4103/0974-9233.102760. PMID: 23248544Free PMC Article
Unifocal and multifocal reactive lymphoid hyperplasia vs follicular lymphoma of the ocular adnexa.
Stacy RC, Jakobiec FA, Schoenfield L, Singh AD
Am J Ophthalmol 2010 Sep;150(3):412-426.e1. doi: 10.1016/j.ajo.2010.04.007. PMID: 20599186

Diagnosis

Anterior segment optical coherence tomography in ocular surface tumours and simulating lesions.
Gündüz AK, Mirzayev I, Okcu Heper A, Kuzu I, Gahramanli Z, Cansiz Ersöz C, Gündüz ÖÖ, Ataoğlu Ö
Eye (Lond) 2023 Apr;37(5):925-937. Epub 2022 Dec 13 doi: 10.1038/s41433-022-02339-1. PMID: 36513855Free PMC Article
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Benign reactive lymphoid hyperplasia of the conjunctiva in childhood.
AlAkeely AG, Alkatan HM, Alsuhaibani AH, AlKhalidi H, Safieh LA, Coupland SE, Edward DP
Br J Ophthalmol 2017 Jul;101(7):933-939. Epub 2016 Nov 29 doi: 10.1136/bjophthalmol-2016-309030. PMID: 27899370
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Ocular adnexal lymphoproliferative lesions.
Liesegang TJ
Mayo Clin Proc 1993 Oct;68(10):1003-10. doi: 10.1016/s0025-6196(12)62275-7. PMID: 8412350

Therapy

Histopathologic Analysis of Conjunctival Lymphoproliferative Disease After Topical Brimonidine Use.
Hwang HB, Kim SY, Ohn K, Kim SY
J Ocul Pharmacol Ther 2019 Nov;35(9):503-511. Epub 2019 Aug 2 doi: 10.1089/jop.2019.0037. PMID: 31373838
Benign Reactive Lymphoid Hyperplasia of the Conjunctiva Treated With Cyclosporine.
Parikh RN, Sandhu HS, Massaro-Giordano G, Goldstein SM, OʼBrien JM
Cornea 2018 Feb;37(2):255-257. doi: 10.1097/ICO.0000000000001452. PMID: 29135567
Topical steroids eye drops in conjunctival reactive lymphoid hyperplasia: Case report.
Moraes BRM, Nascimento MVDD, Neto EDDS, Santo RM
Medicine (Baltimore) 2017 Nov;96(47):e8656. doi: 10.1097/MD.0000000000008656. PMID: 29381940Free PMC Article
Reactive lymphoid hyperplasia 1 month after LASIK surgery.
Reddy S, Finger PT, Chynn EW, Iacob CE
Graefes Arch Clin Exp Ophthalmol 2006 Feb;244(2):262-4. Epub 2005 Jul 21 doi: 10.1007/s00417-005-0007-6. PMID: 16034604
Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis.
Ioannidis AS, Rai P, Mulholland B
Am J Ophthalmol 2005 Mar;139(3):566-8. doi: 10.1016/j.ajo.2004.09.024. PMID: 15767083

Prognosis

Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Benign reactive lymphoid hyperplasia of the conjunctiva in childhood.
AlAkeely AG, Alkatan HM, Alsuhaibani AH, AlKhalidi H, Safieh LA, Coupland SE, Edward DP
Br J Ophthalmol 2017 Jul;101(7):933-939. Epub 2016 Nov 29 doi: 10.1136/bjophthalmol-2016-309030. PMID: 27899370
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Ocular adnexal reactive lymphoid hyperplasia in children.
Al-Mujaini A, Wali U, Ganesh A, Al-Hadabi I, Burney I
Middle East Afr J Ophthalmol 2012 Oct;19(4):406-9. doi: 10.4103/0974-9233.102760. PMID: 23248544Free PMC Article
Ocular adnexal lymphoproliferative lesions.
Liesegang TJ
Mayo Clin Proc 1993 Oct;68(10):1003-10. doi: 10.1016/s0025-6196(12)62275-7. PMID: 8412350

Clinical prediction guides

Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn.
Clemens AC, Loeffler KU, Holz FG, Herwig-Carl MC
Graefes Arch Clin Exp Ophthalmol 2022 Apr;260(4):1415-1425. Epub 2021 Oct 28 doi: 10.1007/s00417-021-05464-x. PMID: 34709452Free PMC Article
Histopathologic Analysis of Conjunctival Lymphoproliferative Disease After Topical Brimonidine Use.
Hwang HB, Kim SY, Ohn K, Kim SY
J Ocul Pharmacol Ther 2019 Nov;35(9):503-511. Epub 2019 Aug 2 doi: 10.1089/jop.2019.0037. PMID: 31373838
Conjunctival lymphoma arising from reactive lymphoid hyperplasia.
Fukuhara J, Kase S, Noda M, Ishijima K, Yamamoto T, Ishida S
World J Surg Oncol 2012 Sep 18;10:194. doi: 10.1186/1477-7819-10-194. PMID: 22985187Free PMC Article
Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis.
Ioannidis AS, Rai P, Mulholland B
Am J Ophthalmol 2005 Mar;139(3):566-8. doi: 10.1016/j.ajo.2004.09.024. PMID: 15767083
Ocular adnexal lymphoproliferative lesions.
Liesegang TJ
Mayo Clin Proc 1993 Oct;68(10):1003-10. doi: 10.1016/s0025-6196(12)62275-7. PMID: 8412350

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