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Ciliary Body Nevus

MedGen UID:
1729960
•Concept ID:
C5420814
•
Neoplastic Process

Definition

A benign nevus that arises from the ciliary body. Only a small percentage of cases progress to ciliary body melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCiliary Body Nevus

Professional guidelines

PubMed

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Ultrasound biomicroscopy: role in diagnosis and management in 130 consecutive patients evaluated for anterior segment tumours.
Conway RM, Chew T, Golchet P, Desai K, Lin S, O'Brien J
Br J Ophthalmol 2005 Aug;89(8):950-5. doi: 10.1136/bjo.2004.059535. PMID: 16024841Free PMC Article

Recent clinical studies

Etiology

Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.
Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC Jr, Bastian BC, Bloomer MM, Pekmezci M
Ophthalmology 2022 Dec;129(12):1429-1439. Epub 2022 Jul 12 doi: 10.1016/j.ophtha.2022.07.002. PMID: 35835335
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
An Update on Oculodermal Melanocytosis and Rare Associated Conditions.
Plateroti AM, Scavella V, Abdolrahimzadeh B, Plateroti R, Rahimi S
Semin Ophthalmol 2017;32(4):524-528. Epub 2016 Apr 15 doi: 10.3109/08820538.2015.1118133. PMID: 27083007
Melanoma of the eye: revealing hidden secrets, one at a time.
Shields CL, Kels JG, Shields JA
Clin Dermatol 2015 Mar-Apr;33(2):183-96. Epub 2015 Jan 14 doi: 10.1016/j.clindermatol.2014.10.010. PMID: 25704938
Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature.
LoRusso FJ, Boniuk M, Font RL
Ophthalmology 2000 Apr;107(4):795-800. doi: 10.1016/s0161-6420(99)00151-7. PMID: 10768345

Diagnosis

Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.
Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC Jr, Bastian BC, Bloomer MM, Pekmezci M
Ophthalmology 2022 Dec;129(12):1429-1439. Epub 2022 Jul 12 doi: 10.1016/j.ophtha.2022.07.002. PMID: 35835335
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
An Update on Oculodermal Melanocytosis and Rare Associated Conditions.
Plateroti AM, Scavella V, Abdolrahimzadeh B, Plateroti R, Rahimi S
Semin Ophthalmol 2017;32(4):524-528. Epub 2016 Apr 15 doi: 10.3109/08820538.2015.1118133. PMID: 27083007
Congenital uveal melanoma?
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature.
LoRusso FJ, Boniuk M, Font RL
Ophthalmology 2000 Apr;107(4):795-800. doi: 10.1016/s0161-6420(99)00151-7. PMID: 10768345

Therapy

Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Eye color and cutaneous nevi predict risk of ocular melanoma in Australia.
Vajdic CM, Kricker A, Giblin M, McKenzie J, Aitken J, Giles GG, Armstrong BK
Int J Cancer 2001 Jun 15;92(6):906-12. doi: 10.1002/ijc.1281. PMID: 11351315
The value of nucleolar organizer regions in uveal melanoma. The Collaborative Ocular Melanoma Study Group.
Marcus DM, Minkovitz JB, Wardwell SD, Albert DM
Am J Ophthalmol 1990 Nov 15;110(5):527-34. doi: 10.1016/s0002-9394(14)77877-8. PMID: 1700611

Prognosis

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.
Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC Jr, Bastian BC, Bloomer MM, Pekmezci M
Ophthalmology 2022 Dec;129(12):1429-1439. Epub 2022 Jul 12 doi: 10.1016/j.ophtha.2022.07.002. PMID: 35835335
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Melanoma of the eye: revealing hidden secrets, one at a time.
Shields CL, Kels JG, Shields JA
Clin Dermatol 2015 Mar-Apr;33(2):183-96. Epub 2015 Jan 14 doi: 10.1016/j.clindermatol.2014.10.010. PMID: 25704938
Pathology of ocular melanomas.
McCartney AC
Br Med Bull 1995 Jul;51(3):678-93. doi: 10.1093/oxfordjournals.bmb.a072986. PMID: 7552088

Clinical prediction guides

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Serum adiponectin, insulin resistance, and uveal melanoma: clinicopathological correlations.
Sevim DG, Kiratli H
Melanoma Res 2016 Apr;26(2):164-72. doi: 10.1097/CMR.0000000000000226. PMID: 26630661
Melanocytoma (magnocellular nevus) of the ciliary body: report of 10 cases and review of the literature.
LoRusso FJ, Boniuk M, Font RL
Ophthalmology 2000 Apr;107(4):795-800. doi: 10.1016/s0161-6420(99)00151-7. PMID: 10768345
Melanocytomas of the optic nerve and uvea.
Khadem JJ, Weiter JJ
Int Ophthalmol Clin 1997 Fall;37(4):149-58. doi: 10.1097/00004397-199703740-00013. PMID: 9429938

Recent systematic reviews

Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563

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