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Recurrent Myelodysplastic/Myeloproliferative Neoplasm

MedGen UID:
1716734
•Concept ID:
C5237729
•
Neoplastic Process

Definition

The reemergence of a myelodysplastic/myeloproliferative neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Myelodysplastic/Myeloproliferative Neoplasm

Professional guidelines

PubMed

Chronic neutrophilic leukemia and atypical chronic myeloid leukemia: 2024 update on diagnosis, genetics, risk stratification, and management.
Szuber N, Orazi A, Tefferi A
Am J Hematol 2024 Jul;99(7):1360-1387. Epub 2024 Apr 21 doi: 10.1002/ajh.27321. PMID: 38644693
Emerging drugs for the treatment of chronic myelomonocytic leukemia.
Ramos Perez J, Montalban-Bravo G
Expert Opin Emerg Drugs 2020 Dec;25(4):515-529. Epub 2020 Dec 13 doi: 10.1080/14728214.2020.1854224. PMID: 33280448
PCM1-JAK2-fusion: a potential treatment target in myelodysplastic-myeloproliferative and other hemato-lymphoid neoplasms.
Hoeller S, Walz C, Reiter A, Dirnhofer S, Tzankov A
Expert Opin Ther Targets 2011 Jan;15(1):53-62. Epub 2010 Nov 20 doi: 10.1517/14728222.2011.538683. PMID: 21091042

Recent clinical studies

Etiology

GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation.
Rajput RV, Arnold DE
Curr Hematol Malig Rep 2023 Aug;18(4):89-97. Epub 2023 May 29 doi: 10.1007/s11899-023-00695-7. PMID: 37247092
The genetic landscape of germline DDX41 variants predisposing to myeloid neoplasms.
Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Molecular genetics of MDS/MPN overlap syndromes.
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
How we manage Philadelphia-negative myeloproliferative neoplasms in pregnancy.
Robinson SE, Harrison CN
Br J Haematol 2020 May;189(4):625-634. Epub 2020 Mar 9 doi: 10.1111/bjh.16453. PMID: 32150650
Myelodysplastic and myeloproliferative neoplasms: updates on the overlap syndromes.
Thota S, Gerds AT
Leuk Lymphoma 2018 Apr;59(4):803-812. Epub 2017 Aug 3 doi: 10.1080/10428194.2017.1357179. PMID: 28771058

Diagnosis

Progression in Myeloid Neoplasms: Beyond the Myeloblast.
Faria C, Tzankov A
Pathobiology 2024;91(1):55-75. Epub 2023 May 11 doi: 10.1159/000530940. PMID: 37232015Free PMC Article
The genetic landscape of germline DDX41 variants predisposing to myeloid neoplasms.
Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Molecular genetics of MDS/MPN overlap syndromes.
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms.
Palomo L, Meggendorfer M, Hutter S, Twardziok S, Ademà V, Fuhrmann I, Fuster-Tormo F, Xicoy B, Zamora L, Acha P, Kerr CM, Kern W, Maciejewski JP, Solé F, Haferlach C, Haferlach T
Blood 2020 Oct 15;136(16):1851-1862. doi: 10.1182/blood.2019004229. PMID: 32573691Free PMC Article
Therapy-Related Myeloid Neoplasms.
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306

Therapy

Azacitidine, lenalidomide and donor lymphocyte infusions for relapse of myelodysplastic syndrome, acute myeloid leukemia and chronic myelomonocytic leukemia after allogeneic transplant: the Azalena-Trial.
Schroeder T, Stelljes M, Christopeit M, Esseling E, Scheid C, Mikesch JH, Rautenberg C, Jäger P, Cadeddu RP, Drusenheimer N, Holtick U, Klein S, Trenschel R, Haas R, Germing U, Kröger N, Kobbe G
Haematologica 2023 Nov 1;108(11):3001-3010. doi: 10.3324/haematol.2022.282570. PMID: 37259567Free PMC Article
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Myelodysplastic and myeloproliferative neoplasms: updates on the overlap syndromes.
Thota S, Gerds AT
Leuk Lymphoma 2018 Apr;59(4):803-812. Epub 2017 Aug 3 doi: 10.1080/10428194.2017.1357179. PMID: 28771058
Eosinophilia in Hematologic Disorders.
Falchi L, Verstovsek S
Immunol Allergy Clin North Am 2015 Aug;35(3):439-52. doi: 10.1016/j.iac.2015.04.004. PMID: 26209894Free PMC Article
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815

Prognosis

Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Molecular genetics of MDS/MPN overlap syndromes.
Hunter AM, Padron E
Best Pract Res Clin Haematol 2020 Sep;33(3):101195. Epub 2020 Jul 5 doi: 10.1016/j.beha.2020.101195. PMID: 33038984
Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms.
Palomo L, Meggendorfer M, Hutter S, Twardziok S, Ademà V, Fuhrmann I, Fuster-Tormo F, Xicoy B, Zamora L, Acha P, Kerr CM, Kern W, Maciejewski JP, Solé F, Haferlach C, Haferlach T
Blood 2020 Oct 15;136(16):1851-1862. doi: 10.1182/blood.2019004229. PMID: 32573691Free PMC Article
Myelodysplastic and myeloproliferative neoplasms: updates on the overlap syndromes.
Thota S, Gerds AT
Leuk Lymphoma 2018 Apr;59(4):803-812. Epub 2017 Aug 3 doi: 10.1080/10428194.2017.1357179. PMID: 28771058
Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes.
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026

Clinical prediction guides

GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation.
Rajput RV, Arnold DE
Curr Hematol Malig Rep 2023 Aug;18(4):89-97. Epub 2023 May 29 doi: 10.1007/s11899-023-00695-7. PMID: 37247092
Molecular landscape and clonal architecture of adult myelodysplastic/myeloproliferative neoplasms.
Palomo L, Meggendorfer M, Hutter S, Twardziok S, Ademà V, Fuhrmann I, Fuster-Tormo F, Xicoy B, Zamora L, Acha P, Kerr CM, Kern W, Maciejewski JP, Solé F, Haferlach C, Haferlach T
Blood 2020 Oct 15;136(16):1851-1862. doi: 10.1182/blood.2019004229. PMID: 32573691Free PMC Article
Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes.
Wall M
Methods Mol Biol 2017;1541:209-222. doi: 10.1007/978-1-4939-6703-2_18. PMID: 27910026
Molecular basis of mast cell disease.
Soucie E, Brenet F, Dubreuil P
Mol Immunol 2015 Jan;63(1):55-60. Epub 2014 Apr 24 doi: 10.1016/j.molimm.2014.03.013. PMID: 24768320
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
Itzykson R, Fenaux P, Solary E
Best Pract Res Clin Haematol 2013 Dec;26(4):387-400. Epub 2013 Oct 1 doi: 10.1016/j.beha.2013.09.006. PMID: 24507815

Recent systematic reviews

Myeloid neoplasms with t(12;22)(p13;q12)/MN1-EVT6: a systematic review of 12 cases.
Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914

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