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Combined Nevus

MedGen UID:
1713726
•Concept ID:
C5237247
•
Neoplastic Process
Synonyms: Clonal Nevus; Inverted Type A Nevus; Melanocytic Nevus with Phenotypic Heterogeneity; Nevus with Atypical Dermal Nodules; Nevus with Dermal Epithelioid Component

Definition

A nevus that contains two or more melanocytic nevus components in the same lesion. The cellular components can be any combination of any nevus variants, but most frequently, a common nevus component is combined with a blue nevus, deep penetrating nevus, or Spitz nevus component. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCombined Nevus

Professional guidelines

PubMed

Blue nevus: classical types and new related entities. A differential diagnostic review.
González-Cámpora R, Galera-Davidson H, Vázquez-Ramírez FJ, Díaz-Cano S
Pathol Res Pract 1994 Jun;190(6):627-35. doi: 10.1016/S0344-0338(11)80402-4. PMID: 7984522

Recent clinical studies

Etiology

Histological features and outcome of inverted type-A melanocytic nevi.
Dadras SS, Lu J, Zembowicz A, Flotte TJ, Mihm MC
J Cutan Pathol 2018 Apr;45(4):254-262. Epub 2018 Feb 13 doi: 10.1111/cup.13106. PMID: 29341232
The scalp hair collar and tuft signs: A retrospective multicenter study of 78 patients with a systematic review of the literature.
Bessis D, Bigorre M, Malissen N, Captier G, Chiaverini C, Abasq C, Barbarot S, Boccara O, Bourrat E, El Fertit H, Eschard C, Hubiche T, Lacour JP, Leboucq N, Mahé E, Mallet S, Marque M, Martin L, Mazereeuw-Hautier J, Milla N, Phan A, Plantin P, Picot MC, Puzenat E, Rigau V, Vabres P, Fraitag S, Boralevi F; Groupe de Recherche Clinique en Dermatologie Pédiatrique
J Am Acad Dermatol 2017 Mar;76(3):478-487. Epub 2016 Oct 11 doi: 10.1016/j.jaad.2016.08.046. PMID: 27742172
Combined blue nevus-smooth muscle hamartoma: a series of 12 cases.
Tzu J, Goldman C, Perry AE, Meehan SA
J Cutan Pathol 2013 Oct;40(10):879-83. Epub 2013 Aug 14 doi: 10.1111/cup.12200. PMID: 23941592
Epithelioid blue nevus: neoplasm Sui generis or variation on a theme?
Groben PA, Harvell JD, White WL
Am J Dermatopathol 2000 Dec;22(6):473-88. doi: 10.1097/00000372-200012000-00001. PMID: 11190438
Pathology and prognostic factors.
Barnhill RL
Curr Opin Oncol 1993 Mar;5(2):364-76. doi: 10.1097/00001622-199303000-00016. PMID: 8457620

Diagnosis

Solitary Intratarsal Blue Nevus.
Charles NC, Kim ET
Ophthalmic Plast Reconstr Surg 2023 Mar-Apr 01;39(2):e33-e35. Epub 2022 Sep 22 doi: 10.1097/IOP.0000000000002284. PMID: 36136733
Blue nevus with smooth muscle hyperplasia: A rare hamartoma.
Higgins AD, Shalin SC
J Cutan Pathol 2022 Mar;49(3):310-313. Epub 2021 Nov 15 doi: 10.1111/cup.14158. PMID: 34716951
Hypopigmented common blue nevus.
Carr S, See J, Wilkinson B, Kossard S
J Cutan Pathol 1997 Sep;24(8):494-8. doi: 10.1111/j.1600-0560.1997.tb01323.x. PMID: 9331895
Blue nevus: classical types and new related entities. A differential diagnostic review.
González-Cámpora R, Galera-Davidson H, Vázquez-Ramírez FJ, Díaz-Cano S
Pathol Res Pract 1994 Jun;190(6):627-35. doi: 10.1016/S0344-0338(11)80402-4. PMID: 7984522
Pathology and prognostic factors.
Barnhill RL
Curr Opin Oncol 1993 Mar;5(2):364-76. doi: 10.1097/00001622-199303000-00016. PMID: 8457620

Therapy

Combined Nevus-Mastocytosis; Random Coincidence or Complex Biological Relationship?
Van Rooyen DM, Grohs RL, Mesbah Ardakani N
Am J Dermatopathol 2021 May 1;43(5):365-367. doi: 10.1097/DAD.0000000000001815. PMID: 33055539
Molecular analysis of atypical deep penetrating nevus progressing to melanoma.
Isales MC, Khan AU, Zhang B, Compres EV, Kim D, Tan TL, Beaubier N, Gerami P
J Cutan Pathol 2020 Dec;47(12):1150-1154. Epub 2020 Jul 6 doi: 10.1111/cup.13775. PMID: 32526042

Prognosis

Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus.
Zembowicz A, Carney JA, Mihm MC
Am J Surg Pathol 2004 Jan;28(1):31-40. doi: 10.1097/00000478-200401000-00002. PMID: 14707861
Malignant cellular blue nevus: a clinicopathological study of 6 cases.
Aloi F, Pich A, Pippione M
Dermatology 1996;192(1):36-40. doi: 10.1159/000246311. PMID: 8832950
The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac myxoma and psammomatous melanotic schwannoma.
Carney JA, Ferreiro JA
Am J Surg Pathol 1996 Mar;20(3):259-72. doi: 10.1097/00000478-199603000-00001. PMID: 8772778
Pathology and prognostic factors.
Barnhill RL
Curr Opin Oncol 1993 Mar;5(2):364-76. doi: 10.1097/00001622-199303000-00016. PMID: 8457620
Histologic classification of the combined nevus. Analysis of the variable expression of melanocytic nevi.
Pulitzer DR, Martin PC, Cohen AP, Reed RJ
Am J Surg Pathol 1991 Dec;15(12):1111-22. doi: 10.1097/00000478-199112000-00001. PMID: 1746678

Clinical prediction guides

Combined nevus of the tarsal conjunctival.
Huerva V, Sánchez MC, Soldevila J, Ascaso FJ
J Fr Ophtalmol 2013 Feb;36(2):e19-22. Epub 2012 Dec 8 doi: 10.1016/j.jfo.2012.03.010. PMID: 23228668
Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus.
Zembowicz A, Carney JA, Mihm MC
Am J Surg Pathol 2004 Jan;28(1):31-40. doi: 10.1097/00000478-200401000-00002. PMID: 14707861
Histologic classification of the combined nevus. Analysis of the variable expression of melanocytic nevi.
Pulitzer DR, Martin PC, Cohen AP, Reed RJ
Am J Surg Pathol 1991 Dec;15(12):1111-22. doi: 10.1097/00000478-199112000-00001. PMID: 1746678
Plaque-type blue nevus combined with lentigo (nevus spilus).
Ishibashi A, Kimura K, Kukita A
J Cutan Pathol 1990 Aug;17(4):241-5. doi: 10.1111/j.1600-0560.1990.tb00093.x. PMID: 2394866

Recent systematic reviews

The scalp hair collar and tuft signs: A retrospective multicenter study of 78 patients with a systematic review of the literature.
Bessis D, Bigorre M, Malissen N, Captier G, Chiaverini C, Abasq C, Barbarot S, Boccara O, Bourrat E, El Fertit H, Eschard C, Hubiche T, Lacour JP, Leboucq N, Mahé E, Mallet S, Marque M, Martin L, Mazereeuw-Hautier J, Milla N, Phan A, Plantin P, Picot MC, Puzenat E, Rigau V, Vabres P, Fraitag S, Boralevi F; Groupe de Recherche Clinique en Dermatologie Pédiatrique
J Am Acad Dermatol 2017 Mar;76(3):478-487. Epub 2016 Oct 11 doi: 10.1016/j.jaad.2016.08.046. PMID: 27742172

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