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Skin detachment

MedGen UID:
1674399
•Concept ID:
C4759673
•
Finding
Synonyms: Detached skin; Epidermal detachment; Skin Sloughing; Skin sloughing
 
HPO: HP:0032156

Definition

Loss of sections of skin either spontaneously or after gentle handling. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin detachment

Professional guidelines

PubMed

Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.
Grünwald P, Mockenhaupt M, Panzer R, Emmert S
J Dtsch Dermatol Ges 2020 Jun;18(6):547-553. Epub 2020 May 29 doi: 10.1111/ddg.14118. PMID: 32469468
Treatment of severe drug reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis and hypersensitivity syndrome.
Ghislain PD, Roujeau JC
Dermatol Online J 2002 Jun;8(1):5. PMID: 12165215
Drug-induced severe skin reactions. Incidence, management and prevention.
Wolkenstein P, Revuz J
Drug Saf 1995 Jul;13(1):56-68. doi: 10.2165/00002018-199513010-00007. PMID: 8527020

Recent clinical studies

Etiology

Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.
Grünwald P, Mockenhaupt M, Panzer R, Emmert S
J Dtsch Dermatol Ges 2020 Jun;18(6):547-553. Epub 2020 May 29 doi: 10.1111/ddg.14118. PMID: 32469468
Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
A Review of the Pathogenesis of Toxic Epidermal Necrolysis.
Kinoshita Y, Saeki H
J Nippon Med Sch 2016;83(6):216-222. doi: 10.1272/jnms.83.216. PMID: 28133001
Stevens-Johnson syndrome and toxic epidermal necrolysis: a review.
Wong A, Malvestiti AA, Hafner Mde F
Rev Assoc Med Bras (1992) 2016 Sep-Oct;62(5):468-73. doi: 10.1590/1806-9282.62.05.468. PMID: 27656858
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Diagnosis

Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis.
Hasegawa A, Abe R
F1000Res 2020;9 Epub 2020 Jun 16 doi: 10.12688/f1000research.24748.1. PMID: 32595945Free PMC Article
Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.
Grünwald P, Mockenhaupt M, Panzer R, Emmert S
J Dtsch Dermatol Ges 2020 Jun;18(6):547-553. Epub 2020 May 29 doi: 10.1111/ddg.14118. PMID: 32469468
Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Stevens-Johnson syndrome and toxic epidermal necrolysis: a review.
Wong A, Malvestiti AA, Hafner Mde F
Rev Assoc Med Bras (1992) 2016 Sep-Oct;62(5):468-73. doi: 10.1590/1806-9282.62.05.468. PMID: 27656858
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Therapy

Stevens-johnson Syndrome and Toxic Epidermal Necrolysis: An Overview of Diagnosis, Therapy Options and Prognosis of Patients.
Garg VK, Buttar HS, Bhat SA, Ainur N, Priya T, Kashyap D, Tuli HS
Recent Adv Inflamm Allergy Drug Discov 2023;17(2):110-120. doi: 10.2174/2772270817666230821102441. PMID: 37605396
Skin Contour Sutures in Rhinoplasty.
Zholtikov V, Kosins A, Ouerghi R, Daniel RK
Aesthet Surg J 2023 Mar 15;43(4):422-432. doi: 10.1093/asj/sjac281. PMID: 36323644
Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Adverse drug reactions and organ damage: The skin.
Marzano AV, Borghi A, Cugno M
Eur J Intern Med 2016 Mar;28:17-24. Epub 2015 Dec 7 doi: 10.1016/j.ejim.2015.11.017. PMID: 26674736
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Prognosis

Skin Contour Sutures in Rhinoplasty.
Zholtikov V, Kosins A, Ouerghi R, Daniel RK
Aesthet Surg J 2023 Mar 15;43(4):422-432. doi: 10.1093/asj/sjac281. PMID: 36323644
Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis.
Hasegawa A, Abe R
F1000Res 2020;9 Epub 2020 Jun 16 doi: 10.12688/f1000research.24748.1. PMID: 32595945Free PMC Article
Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.
Grünwald P, Mockenhaupt M, Panzer R, Emmert S
J Dtsch Dermatol Ges 2020 Jun;18(6):547-553. Epub 2020 May 29 doi: 10.1111/ddg.14118. PMID: 32469468
Stevens-Johnson syndrome and toxic epidermal necrolysis: a review.
Wong A, Malvestiti AA, Hafner Mde F
Rev Assoc Med Bras (1992) 2016 Sep-Oct;62(5):468-73. doi: 10.1590/1806-9282.62.05.468. PMID: 27656858
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Clinical prediction guides

Skin Contour Sutures in Rhinoplasty.
Zholtikov V, Kosins A, Ouerghi R, Daniel RK
Aesthet Surg J 2023 Mar 15;43(4):422-432. doi: 10.1093/asj/sjac281. PMID: 36323644
Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis.
Hasegawa A, Abe R
F1000Res 2020;9 Epub 2020 Jun 16 doi: 10.12688/f1000research.24748.1. PMID: 32595945Free PMC Article
Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment.
Grünwald P, Mockenhaupt M, Panzer R, Emmert S
J Dtsch Dermatol Ges 2020 Jun;18(6):547-553. Epub 2020 May 29 doi: 10.1111/ddg.14118. PMID: 32469468
Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T
Clin Rev Allergy Immunol 2018 Feb;54(1):147-176. doi: 10.1007/s12016-017-8654-z. PMID: 29188475
Toxic epidermal necrolysis and Stevens-Johnson syndrome.
Harr T, French LE
Orphanet J Rare Dis 2010 Dec 16;5:39. doi: 10.1186/1750-1172-5-39. PMID: 21162721Free PMC Article

Recent systematic reviews

Interventions for toxic epidermal necrolysis.
Majumdar S, Mockenhaupt M, Roujeau J, Townshend A
Cochrane Database Syst Rev 2002;2002(4):CD001435. doi: 10.1002/14651858.CD001435. PMID: 12519556Free PMC Article

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