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Elevated urine glycolate

MedGen UID:
1670965
•Concept ID:
C4732789
•
Finding
HPO: HP:0031981

Definition

An increased concentration of glycolate in the urine. [from HPO]

Professional guidelines

PubMed

Systematic assessment of urinary hydroxy-oxo-glutarate for diagnosis and follow-up of primary hyperoxaluria type III.
Ventzke A, Feldkötter M, Wei A, Becker J, Beck BB, Hoppe B
Pediatr Nephrol 2017 Dec;32(12):2263-2271. Epub 2017 Jul 15 doi: 10.1007/s00467-017-3731-3. PMID: 28711958
The relationship of panic disorder and its treatment outcome to 24-hour urinary MHPG levels.
Garvey M, Noyes R Jr, Cook B, Tollefson G
Psychiatry Res 1989 Oct;30(1):53-61. doi: 10.1016/0165-1781(89)90171-6. PMID: 2594871
Platelet and plasma amine oxidase inhibition and urinary amine excretion changes during phenelzine treatment.
Murphy DL, Brand E, Goldman T, Baker M, Wright C, van Kammen D, Gordon E
J Nerv Ment Dis 1977 Feb;164(2):129-34. doi: 10.1097/00005053-197702000-00008. PMID: 836485

Recent clinical studies

Etiology

Glycolate oxidase-1 gene variants influence the risk of hyperoxaluria and renal stone development.
Patel YP, Patel SB, Patel P, Parikh A, Soni S, Srivastava R, Raval C, Ganpule AP, Desai MR, Patel SG, Pandey SN
World J Urol 2024 Jan 12;42(1):28. doi: 10.1007/s00345-023-04718-z. PMID: 38214752
Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults.
Chen O, Blonquist TM, Mah E, Sanoshy K, Beckman D, Nieman KM, Winters BL, Anthony JC, Verdin E, Newman JC, Stubbs BJ
Nutrients 2021 Jun 16;13(6) doi: 10.3390/nu13062066. PMID: 34208742Free PMC Article
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083
Persistent health effects of dioxin contamination in herbicide production.
Neuberger M, Rappe C, Bergek S, Cai H, Hansson M, Jäger R, Kundi M, Lim CK, Wingfors H, Smith AG
Environ Res 1999 Oct;81(3):206-14. doi: 10.1006/enrs.1999.3983. PMID: 10585016
Identification and quantitation of phenylethylene glycol in human and rat urine, and its elevation in phenylketonuria.
Edwards DJ, Rizk M
Clin Chim Acta 1979 Jul 2;95(1):1-10. doi: 10.1016/0009-8981(79)90329-2. PMID: 509720

Diagnosis

Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats.
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE
Clin Toxicol (Phila) 2022 Mar;60(3):324-331. Epub 2021 Jul 19 doi: 10.1080/15563650.2021.1953049. PMID: 34278906Free PMC Article
Rapid liquid chromatography tandem mass-spectrometry screening method for urinary metabolites of primary hyperoxaluria.
Woodward G, Pryke R, Hoppe B, Rumsby G
Ann Clin Biochem 2019 Mar;56(2):232-239. Epub 2018 Nov 14 doi: 10.1177/0004563218811365. PMID: 30373392
Simultaneous analysis of urinary metabolites for preliminary identification of primary hyperoxaluria.
Clifford-Mobley O, Hewitt L, Rumsby G
Ann Clin Biochem 2016 Jul;53(Pt 4):485-94. Epub 2015 Sep 4 doi: 10.1177/0004563215606158. PMID: 26342005
Primary hyperoxaluria.
Tantbirojn P, Kittikowit W, Kingwattanakul P
J Med Assoc Thai 2007 Aug;90(8):1669-72. PMID: 17927001
Catecholamine metabolism in neuroblastoma.
LaBrosse EH, Comoy E, Bohuon C, Zucker JM, Schweisguth O
J Natl Cancer Inst 1976 Sep;57(3):633-8. doi: 10.1093/jnci/57.3.633. PMID: 10450

Therapy

Urinary concentrations of GHB and its novel amino acid and carnitine conjugates following controlled GHB administration to humans.
Steuer AE, Bavato F, Schnider LK, Dornbierer DA, Bosch OG, Quednow BB, Seifritz E, Steuer C, Kraemer T
Sci Rep 2023 Jun 2;13(1):8983. doi: 10.1038/s41598-023-36213-1. PMID: 37268859Free PMC Article
Tolerability and Safety of a Novel Ketogenic Ester, Bis-Hexanoyl (R)-1,3-Butanediol: A Randomized Controlled Trial in Healthy Adults.
Chen O, Blonquist TM, Mah E, Sanoshy K, Beckman D, Nieman KM, Winters BL, Anthony JC, Verdin E, Newman JC, Stubbs BJ
Nutrients 2021 Jun 16;13(6) doi: 10.3390/nu13062066. PMID: 34208742Free PMC Article
A neonate with metabolic acidosis: Intentional ethylene glycol poisoning.
Greenky D, Ball TT, Murray B
Am J Emerg Med 2021 Jun;44:478.e5-478.e6. Epub 2020 Nov 6 doi: 10.1016/j.ajem.2020.10.078. PMID: 33176951
Characterizing concentrations of diethylene glycol and suspected metabolites in human serum, urine, and cerebrospinal fluid samples from the Panama DEG mass poisoning.
Schier JG, Hunt DR, Perala A, McMartin KE, Bartels MJ, Lewis LS, McGeehin MA, Flanders WD
Clin Toxicol (Phila) 2013 Dec;51(10):923-9. Epub 2013 Nov 25 doi: 10.3109/15563650.2013.850504. PMID: 24266434Free PMC Article
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083

Prognosis

MicroRNA-4516 in Urinary Exosomes as a Biomarker of Premature Ovarian Insufficiency.
Umair Z, Baek MO, Song J, An S, Chon SJ, Yoon MS
Cells 2022 Sep 7;11(18) doi: 10.3390/cells11182797. PMID: 36139370Free PMC Article
Glycolate oxidase deficiency in a patient with congenital hyperinsulinism and unexplained hyperoxaluria.
Clifford-Mobley O, Rumsby G, Kanodia S, Didi M, Holt R, Senniappan S
Pediatr Nephrol 2017 Nov;32(11):2159-2163. Epub 2017 Jul 27 doi: 10.1007/s00467-017-3741-1. PMID: 28752386
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083
Acute propylene glycol ingestion.
Brooks DE, Wallace KL
J Toxicol Clin Toxicol 2002;40(4):513-6. doi: 10.1081/clt-120006755. PMID: 12217005
Catecholamine metabolism in neuroblastoma.
LaBrosse EH, Comoy E, Bohuon C, Zucker JM, Schweisguth O
J Natl Cancer Inst 1976 Sep;57(3):633-8. doi: 10.1093/jnci/57.3.633. PMID: 10450

Clinical prediction guides

Succinic semialdehyde dehydrogenase deficiency in mice and in humans: An untargeted metabolomics perspective.
Peters TMA, Engelke UFH, de Boer S, Reintjes JTG, Roullet JB, Broekman S, de Vrieze E, van Wijk E, Wamelink MMC, Artuch R, Barić I, Merx J, Boltje TJ, Martens J, Willemsen MAAP, Verbeek MM, Wevers RA, Gibson KM, Coene KLM
J Inherit Metab Dis 2024 May;47(3):417-430. Epub 2023 Jul 29 doi: 10.1002/jimd.12657. PMID: 37455357
Diethylene glycol produces nephrotoxic and neurotoxic effects in female rats.
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE
Clin Toxicol (Phila) 2022 Mar;60(3):324-331. Epub 2021 Jul 19 doi: 10.1080/15563650.2021.1953049. PMID: 34278906Free PMC Article
Neurotoxic effects of nephrotoxic compound diethylene glycol.
Jamison CN, Dayton RD, Latimer B, McKinney MP, Mitchell HG, McMartin KE
Clin Toxicol (Phila) 2021 Sep;59(9):810-821. Epub 2021 Jan 21 doi: 10.1080/15563650.2021.1874403. PMID: 33475432Free PMC Article
Simultaneous analysis of urinary metabolites for preliminary identification of primary hyperoxaluria.
Clifford-Mobley O, Hewitt L, Rumsby G
Ann Clin Biochem 2016 Jul;53(Pt 4):485-94. Epub 2015 Sep 4 doi: 10.1177/0004563215606158. PMID: 26342005
Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations.
Kingman A, Hyman J, Masten SA, Jayaram B, Smith C, Eichmiller F, Arnold MC, Wong PA, Schaeffer JM, Solanki S, Dunn WJ
J Am Dent Assoc 2012 Dec;143(12):1292-302. doi: 10.14219/jada.archive.2012.0090. PMID: 23204083

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