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Middle insomnia

MedGen UID:
140745
•Concept ID:
C0393761
•
Mental or Behavioral Dysfunction
Synonyms: Broken sleep; Difficulty in sleep maintenance; Difficulty staying asleep; Fitful sleep; Interrupted sleep; Keeps waking up; Middle Insomnia; Night waking; Nocturnal awakening
SNOMED CT: Middle insomnia (67233009); Difficulty staying asleep (67233009); Night waking (67233009); Keeps waking up (67233009); Broken sleep (67233009); Interrupted sleep (67233009); Fitful sleep (67233009); Difficulty in sleep maintenance (67233009); Nocturnal awakening (67233009)

Definition

Difficulty maintaining sleep. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle insomnia

Professional guidelines

PubMed

The relationship between the HDRS insomnia items and polysomnographic (PSG) measures in individuals with treatment-resistant depression.
Hejazi NS, Farmer CA, Oppenheimer M, Falodun TB, Park LT, Duncan WC Jr, Zarate CA Jr
J Psychiatr Res 2022 Apr;148:27-33. Epub 2022 Jan 11 doi: 10.1016/j.jpsychires.2022.01.022. PMID: 35092868Free PMC Article
Sleep in Schizophrenia: Pathology and Treatment.
Benson KL
Sleep Med Clin 2015 Mar;10(1):49-55. doi: 10.1016/j.jsmc.2014.11.001. PMID: 26055673
Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Recent clinical studies

Etiology

Insomnia Symptoms and Suicide-Related Ideation in U.S. Army Service Members.
Vargas I, Perlis ML, Grandner M, Gencarelli A, Khader W, Zandberg LJ, Klingaman EA, Goldschmied JR, Gehrman PR, Brown GK, Thase ME
Behav Sleep Med 2020 Nov-Dec;18(6):820-836. Epub 2019 Nov 18 doi: 10.1080/15402002.2019.1693373. PMID: 31738588
Sleep-Associated Adverse Events During Methylphenidate Treatment of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis.
Faraone SV, Po MD, Komolova M, Cortese S
J Clin Psychiatry 2019 Apr 30;80(3) doi: 10.4088/JCP.18r12210. PMID: 31090281Free PMC Article
Sleep problems and internet addiction among children and adolescents: a longitudinal study.
Chen YL, Gau SS
J Sleep Res 2016 Aug;25(4):458-65. Epub 2016 Feb 8 doi: 10.1111/jsr.12388. PMID: 26854132
Insomnia in untreated sleep apnea patients compared to controls.
Björnsdóttir E, Janson C, Gíslason T, Sigurdsson JF, Pack AI, Gehrman P, Benediktsdóttir B
J Sleep Res 2012 Apr;21(2):131-8. Epub 2011 Oct 12 doi: 10.1111/j.1365-2869.2011.00972.x. PMID: 21988168Free PMC Article
Insomnia subtypes and their relationship to excessive daytime sleepiness in Brazilian community-dwelling older adults.
Hara C, Stewart R, Lima-Costa MF, Rocha FL, Fuzikawa C, Uchoa E, Firmo JO, Castro-Costa É
Sleep 2011 Aug 1;34(8):1111-7. doi: 10.5665/SLEEP.1172. PMID: 21804673Free PMC Article

Diagnosis

Mental Health in Patients With Adrenal Incidentalomas: Is There a Relation With Different Degrees of Cortisol Secretion?
Morelli V, Ghielmetti A, Caldiroli A, Grassi S, Siri FM, Caletti E, Mucci F, Aresta C, Passeri E, Pugliese F, Di Giorgio A, Corbetta S, Scillitani A, Arosio M, Buoli M, Chiodini I
J Clin Endocrinol Metab 2021 Jan 1;106(1):e130-e139. doi: 10.1210/clinem/dgaa695. PMID: 33017843Free PMC Article
Symptomatic differences and symptoms stability in unipolar and bipolar depression. Medical charts review in 99 inpatients.
Gosek P, Heitzman J, Stefanowski B, Antosik-Wójcińska AZ, Parnowski T
Psychiatr Pol 2019 Jun 30;53(3):655-672. doi: 10.12740/PP/102656. PMID: 31522204
Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279
Sleeping with the enemy: sleep and quality of life in patients with lung cancer.
Dean GE, Abu Sabbah E, Yingrengreung S, Ziegler P, Chen H, Steinbrenner LM, Dickerson SS
Cancer Nurs 2015 Jan-Feb;38(1):60-70. doi: 10.1097/NCC.0000000000000128. PMID: 25486204
Insomnia and complicated grief symptoms in bereaved college students.
Hardison HG, Neimeyer RA, Lichstein KL
Behav Sleep Med 2005;3(2):99-111. doi: 10.1207/s15402010bsm0302_4. PMID: 15802260

Therapy

Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Sleep-Associated Adverse Events During Methylphenidate Treatment of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis.
Faraone SV, Po MD, Komolova M, Cortese S
J Clin Psychiatry 2019 Apr 30;80(3) doi: 10.4088/JCP.18r12210. PMID: 31090281Free PMC Article
Sleep in Schizophrenia: Pathology and Treatment.
Benson KL
Sleep Med Clin 2015 Mar;10(1):49-55. doi: 10.1016/j.jsmc.2014.11.001. PMID: 26055673
Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279
Antidepressant withdrawal phenomena.
Dilsaver SC, Greden JF
Biol Psychiatry 1984 Feb;19(2):237-56. PMID: 6324897

Prognosis

The relationship between the HDRS insomnia items and polysomnographic (PSG) measures in individuals with treatment-resistant depression.
Hejazi NS, Farmer CA, Oppenheimer M, Falodun TB, Park LT, Duncan WC Jr, Zarate CA Jr
J Psychiatr Res 2022 Apr;148:27-33. Epub 2022 Jan 11 doi: 10.1016/j.jpsychires.2022.01.022. PMID: 35092868Free PMC Article
Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Longitudinal effects of nocturnal insomnia symptom subtypes and nonrestorative sleep on the incidence of depression among community-dwelling older adults: results from the Health and Retirement Study.
Chen TY, Saito Y
Sleep Med 2021 Mar;79:155-163. Epub 2021 Jan 9 doi: 10.1016/j.sleep.2021.01.003. PMID: 33540204
Sleep problems and internet addiction among children and adolescents: a longitudinal study.
Chen YL, Gau SS
J Sleep Res 2016 Aug;25(4):458-65. Epub 2016 Feb 8 doi: 10.1111/jsr.12388. PMID: 26854132
Insomnia as a risk factor for onset of depression in the elderly.
Perlis ML, Smith LJ, Lyness JM, Matteson SR, Pigeon WR, Jungquist CR, Tu X
Behav Sleep Med 2006;4(2):104-13. doi: 10.1207/s15402010bsm0402_3. PMID: 16579719

Clinical prediction guides

The relationship between the HDRS insomnia items and polysomnographic (PSG) measures in individuals with treatment-resistant depression.
Hejazi NS, Farmer CA, Oppenheimer M, Falodun TB, Park LT, Duncan WC Jr, Zarate CA Jr
J Psychiatr Res 2022 Apr;148:27-33. Epub 2022 Jan 11 doi: 10.1016/j.jpsychires.2022.01.022. PMID: 35092868Free PMC Article
Insomnia, Suicidal Ideation, and Suicide Attempts in the Clinical Antipsychotic Trials of Intervention Effectiveness.
Miller BJ, McEvoy JP, McCall WV
J Clin Psychiatry 2021 Mar 23;82(3) doi: 10.4088/JCP.20m13338. PMID: 34033271
Longitudinal effects of nocturnal insomnia symptom subtypes and nonrestorative sleep on the incidence of depression among community-dwelling older adults: results from the Health and Retirement Study.
Chen TY, Saito Y
Sleep Med 2021 Mar;79:155-163. Epub 2021 Jan 9 doi: 10.1016/j.sleep.2021.01.003. PMID: 33540204
Sleep-Associated Adverse Events During Methylphenidate Treatment of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis.
Faraone SV, Po MD, Komolova M, Cortese S
J Clin Psychiatry 2019 Apr 30;80(3) doi: 10.4088/JCP.18r12210. PMID: 31090281Free PMC Article
Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Recent systematic reviews

Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

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