U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tissue Kallikrein Deficiency

MedGen UID:
1374188
•Concept ID:
C4331419
•
Disease or Syndrome

Definition

A disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTissue Kallikrein Deficiency

Professional guidelines

PubMed

Design and characterization of α1-antitrypsin variants for treatment of contact system-driven thromboinflammation.
de Maat S, Sanrattana W, Mailer RK, Parr NMJ, Hessing M, Koetsier RM, Meijers JCM, Pasterkamp G, Renné T, Maas C
Blood 2019 Nov 7;134(19):1658-1669. doi: 10.1182/blood.2019000481. PMID: 31366623Free PMC Article
Ecallantide: a plasma kallikrein inhibitor for the treatment of acute attacks of hereditary angioedema.
Stolz LE, Horn PT
Drugs Today (Barc) 2010 Aug;46(8):547-55. doi: 10.1358/dot.2010.46.8.1507205. PMID: 20830315
Genetic screening of candidate genes for a prothrombotic interaction with type I protein C deficiency in a large kindred.
Scott BT, Bovill EG, Callas PW, Hasstedt SJ, Leppert MF, Valliere JE, Varvil TS, Long GL
Thromb Haemost 2001 Jan;85(1):82-7. PMID: 11204593

Recent clinical studies

Etiology

Tissue kallikrein deficiency, insulin resistance, and diabetes in mouse and man.
Potier L, Waeckel L, Fumeron F, Bodin S, Fysekidis M, Chollet C, Bellili N, Bonnet F, Gusto G, Velho G, Marre M, Alhenc-Gelas F, Roussel R, Bouby N; DESIR Study Group
J Endocrinol 2014 May;221(2):297-308. Epub 2014 Apr 22 doi: 10.1530/JOE-13-0529. PMID: 24599937

Therapy

Partial genetic deficiency in tissue kallikrein impairs adaptation to high potassium intake in humans.
Monteiro JS, Blanchard A, Curis E, Chambrey R, Jeunemaitre X, Azizi M
Kidney Int 2013 Dec;84(6):1271-7. Epub 2013 Jun 12 doi: 10.1038/ki.2013.224. PMID: 23760292

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...