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Bone Marrow Suppression

MedGen UID:
128928
•Concept ID:
C0280962
•
Disease or Syndrome
Synonyms: Bone Marrow Depression; Myelosuppression

Definition

A condition in which the production of red blood cells, white blood cells, and/or platelets by bone marrow stem cells is inhibited, usually as a side effect of treatment with various anti-cancer agents, radiation, or tumor development within the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Marrow Suppression

Professional guidelines

PubMed

Neutropenic ulcers in oncology: terminology, diagnosis, and management.
Güneri P, Epstein JB, Bolukbasi G, Spielberger RT
Support Care Cancer 2023 Nov 22;31(12):716. doi: 10.1007/s00520-023-08187-3. PMID: 37991547
Principles of Surgical Management of Peritoneal Mesothelioma.
Steadman JA, Grotz TE
J Natl Compr Canc Netw 2023 Sep;21(9):981-986. doi: 10.6004/jnccn.2023.7055. PMID: 37673112
The Treatment of Chronic Lymphatic Leukemia.
Tresckow JV, Eichhorst B, Bahlo J, Hallek M
Dtsch Arztebl Int 2019 Jan 25;116(4):41-46. doi: 10.3238/arztebl.2019.0041. PMID: 30855005Free PMC Article

Recent clinical studies

Etiology

Acupuncture for cancer-related conditions: An overview of systematic reviews.
Zhang XW, Hou WB, Pu FL, Wang XF, Wang YR, Yang M, Cheng K, Wang Y, Robinson N, Liu JP
Phytomedicine 2022 Nov;106:154430. Epub 2022 Sep 5 doi: 10.1016/j.phymed.2022.154430. PMID: 36099656
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Clinical aspects of feline retroviruses: a review.
Hartmann K
Viruses 2012 Oct 31;4(11):2684-710. doi: 10.3390/v4112684. PMID: 23202500Free PMC Article
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Diagnosis

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Methotrexate overdose in clinical practice.
Pannu AK
Curr Drug Metab 2019;20(9):714-719. doi: 10.2174/1389200220666190806140844. PMID: 31385765
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359
Oral pathology in inflammatory bowel disease.
Muhvić-Urek M, Tomac-Stojmenović M, Mijandrušić-Sinčić B
World J Gastroenterol 2016 Jul 7;22(25):5655-67. doi: 10.3748/wjg.v22.i25.5655. PMID: 27433081Free PMC Article
Osteopetrosis.
Stark Z, Savarirayan R
Orphanet J Rare Dis 2009 Feb 20;4:5. doi: 10.1186/1750-1172-4-5. PMID: 19232111Free PMC Article

Therapy

JAK Inhibitors in Solid Organ Transplantation.
Assadiasl S, Mojtahedi H, Nicknam MH
J Clin Pharmacol 2023 Dec;63(12):1330-1343. Epub 2023 Aug 9 doi: 10.1002/jcph.2325. PMID: 37500063
Neutropenia in pediatric solid organ transplant.
Harshman LA, Williams R, Engen RM
Pediatr Transplant 2022 Dec;26(8):e14378. Epub 2022 Aug 20 doi: 10.1111/petr.14378. PMID: 35986635
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article
Thrombocytopenia in chronic liver disease.
Peck-Radosavljevic M
Liver Int 2017 Jun;37(6):778-793. Epub 2016 Dec 27 doi: 10.1111/liv.13317. PMID: 27860293
Hydroxyurea.
Bowers M
BETA 1997 Mar:9-11. PMID: 11364534

Prognosis

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Principles of Surgical Management of Peritoneal Mesothelioma.
Steadman JA, Grotz TE
J Natl Compr Canc Netw 2023 Sep;21(9):981-986. doi: 10.6004/jnccn.2023.7055. PMID: 37673112
Platelets as a Gauge of Liver Disease Kinetics?
Chen SH, Tsai SC, Lu HC
Int J Mol Sci 2022 Sep 28;23(19) doi: 10.3390/ijms231911460. PMID: 36232759Free PMC Article
Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment.
Zhang Y, Lou Y, Wang J, Yu C, Shen W
Front Immunol 2020;11:609705. Epub 2021 Jan 21 doi: 10.3389/fimmu.2020.609705. PMID: 33552068Free PMC Article
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article

Clinical prediction guides

Hepatitis D: A Review.
Negro F, Lok AS
JAMA 2023 Dec 26;330(24):2376-2387. doi: 10.1001/jama.2023.23242. PMID: 37943548
Tumour extracellular vesicles and particles induce liver metabolic dysfunction.
Wang G, Li J, Bojmar L, Chen H, Li Z, Tobias GC, Hu M, Homan EA, Lucotti S, Zhao F, Posada V, Oxley PR, Cioffi M, Kim HS, Wang H, Lauritzen P, Boudreau N, Shi Z, Burd CE, Zippin JH, Lo JC, Pitt GS, Hernandez J, Zambirinis CP, Hollingsworth MA, Grandgenett PM, Jain M, Batra SK, DiMaio DJ, Grem JL, Klute KA, Trippett TM, Egeblad M, Paul D, Bromberg J, Kelsen D, Rajasekhar VK, Healey JH, Matei IR, Jarnagin WR, Schwartz RE, Zhang H, Lyden D
Nature 2023 Jun;618(7964):374-382. Epub 2023 May 24 doi: 10.1038/s41586-023-06114-4. PMID: 37225988Free PMC Article
Research Status and Molecular Mechanism of the Traditional Chinese Medicine and Antitumor Therapy Combined Strategy Based on Tumor Microenvironment.
Zhang Y, Lou Y, Wang J, Yu C, Shen W
Front Immunol 2020;11:609705. Epub 2021 Jan 21 doi: 10.3389/fimmu.2020.609705. PMID: 33552068Free PMC Article
Methotrexate overdose in clinical practice.
Pannu AK
Curr Drug Metab 2019;20(9):714-719. doi: 10.2174/1389200220666190806140844. PMID: 31385765
Chronic Hepatitis B Infection: A Review.
Tang LSY, Covert E, Wilson E, Kottilil S
JAMA 2018 May 1;319(17):1802-1813. doi: 10.1001/jama.2018.3795. PMID: 29715359

Recent systematic reviews

Effectiveness of Acupuncture for Relieving Chemotherapy-Induced Bone Marrow Suppression: A Systematic Review with a Meta-analysis and Trial Sequential Analysis.
Shih YW, Wang MH, Monsen KA, Chang CW, Rias YA, Tsai HT
J Integr Complement Med 2023 Oct;29(10):621-636. Epub 2023 May 10 doi: 10.1089/jicm.2022.0735. PMID: 37163212
Transcutaneous electronic acupoint stimulation improves bone marrow suppression in lung cancer patients following chemotherapy: A systematic review and meta-analysis of randomized controlled trials.
Wei Y, Zheng Y
Medicine (Baltimore) 2023 Apr 21;102(16):e33571. doi: 10.1097/MD.0000000000033571. PMID: 37083807Free PMC Article
Clinical development of WEE1 inhibitors in gynecological cancers: A systematic review.
Schutte T, Embaby A, Steeghs N, van der Mierden S, van Driel W, Rijlaarsdam M, Huitema A, Opdam F
Cancer Treat Rev 2023 Apr;115:102531. Epub 2023 Mar 3 doi: 10.1016/j.ctrv.2023.102531. PMID: 36893690
Cyclophosphamide for connective tissue disease-associated interstitial lung disease.
Barnes H, Holland AE, Westall GP, Goh NS, Glaspole IN
Cochrane Database Syst Rev 2018 Jan 3;1(1):CD010908. doi: 10.1002/14651858.CD010908.pub2. PMID: 29297205Free PMC Article
Anemia in inflammatory bowel disease.
Giannini S, Martes C
Minerva Gastroenterol Dietol 2006 Sep;52(3):275-91. PMID: 16971872

Supplemental Content

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