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Decreased urine creatinine level

MedGen UID:
1053968
•Concept ID:
CN376625
•
Finding
HPO: HP:6000115

Definition

The amount of creatinine in the urine, normalized for urine concentration, is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urine creatinine level

Professional guidelines

PubMed

Acute kidney injury, its definition, and treatment in adults: guidelines and reality.
Matuszkiewicz-Rowińska J, Małyszko J
Pol Arch Intern Med 2020 Dec 22;130(12):1074-1080. Epub 2020 May 19 doi: 10.20452/pamw.15373. PMID: 32426960
Diabetic Kidney Disease: Diagnosis, Treatment, and Prevention.
McGrath K, Edi R
Am Fam Physician 2019 Jun 15;99(12):751-759. PMID: 31194487
National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification.
Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G; National Kidney Foundation
Ann Intern Med 2003 Jul 15;139(2):137-47. doi: 10.7326/0003-4819-139-2-200307150-00013. PMID: 12859163

Recent clinical studies

Etiology

Prevalence of Chronic Kidney Disease in China: Results From the Sixth China Chronic Disease and Risk Factor Surveillance.
Wang L, Xu X, Zhang M, Hu C, Zhang X, Li C, Nie S, Huang Z, Zhao Z, Hou FF, Zhou M
JAMA Intern Med 2023 Apr 1;183(4):298-310. doi: 10.1001/jamainternmed.2022.6817. PMID: 36804760Free PMC Article
Urinary Epidermal Growth Factor: A Promising "Next Generation" Biomarker in Kidney Disease.
Cortvrindt C, Speeckaert R, Delanghe JR, Speeckaert MM
Am J Nephrol 2022;53(5):372-387. Epub 2022 May 10 doi: 10.1159/000524586. PMID: 35537382
The Effects of Febuxostat on Urine NGAL and Urine KIM-1 in Patients with Hyperuricemia.
Tang Y, Liu T, Cai Q, Zhao M
J Healthc Eng 2022;2022:6028611. Epub 2022 Apr 4 doi: 10.1155/2022/6028611. PMID: 35419185Free PMC Article
Kidney Disease: Acute Kidney Injury.
Mahowald M, Khayat M
FP Essent 2021 Oct;509:11-19. PMID: 34643360
Acute kidney injury, its definition, and treatment in adults: guidelines and reality.
Matuszkiewicz-Rowińska J, Małyszko J
Pol Arch Intern Med 2020 Dec 22;130(12):1074-1080. Epub 2020 May 19 doi: 10.20452/pamw.15373. PMID: 32426960

Diagnosis

Urinary Epidermal Growth Factor: A Promising "Next Generation" Biomarker in Kidney Disease.
Cortvrindt C, Speeckaert R, Delanghe JR, Speeckaert MM
Am J Nephrol 2022;53(5):372-387. Epub 2022 May 10 doi: 10.1159/000524586. PMID: 35537382
Acute kidney injury, its definition, and treatment in adults: guidelines and reality.
Matuszkiewicz-Rowińska J, Małyszko J
Pol Arch Intern Med 2020 Dec 22;130(12):1074-1080. Epub 2020 May 19 doi: 10.20452/pamw.15373. PMID: 32426960
Subclinical AKI: ready for primetime in clinical practice?
Vanmassenhove J, Van Biesen W, Vanholder R, Lameire N
J Nephrol 2019 Feb;32(1):9-16. Epub 2018 Dec 6 doi: 10.1007/s40620-018-00566-y. PMID: 30523562
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364

Therapy

Association between urine 6-sulfatoxy-melatonin level and intravesical Bacillus Calmette-Guerin treatment-induced sleep quality deterioration in patients with non-muscle invasive bladder cancer.
Miyake M, Nishimura N, Ohnishi S, Oda Y, Miyamoto T, Shimizu T, Hori S, Morizawa Y, Gotoh D, Nakai Y, Anai S, Torimoto K, Aoki K, Fujii T, Tanaka N, Fujimoto K
Support Care Cancer 2022 Jul;30(7):6145-6153. Epub 2022 Apr 14 doi: 10.1007/s00520-022-07043-0. PMID: 35426045
The Effects of Febuxostat on Urine NGAL and Urine KIM-1 in Patients with Hyperuricemia.
Tang Y, Liu T, Cai Q, Zhao M
J Healthc Eng 2022;2022:6028611. Epub 2022 Apr 4 doi: 10.1155/2022/6028611. PMID: 35419185Free PMC Article
Effect of high-dose intravenous ascorbic acid on cancer patients following ketogenic diet.
Sebastian S, Paul A, Joby J, Saijan S, Vilapurathu JK
J Cancer Res Ther 2021 Oct-Dec;17(6):1583-1586. doi: 10.4103/jcrt.JCRT_973_19. PMID: 34916403
Nephrology Update: Acute Kidney Injury.
Sarabu N, Rahman M
FP Essent 2016 May;444:11-7. PMID: 27163760
Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial.
Pitt B, Kober L, Ponikowski P, Gheorghiade M, Filippatos G, Krum H, Nowack C, Kolkhof P, Kim SY, Zannad F
Eur Heart J 2013 Aug;34(31):2453-63. Epub 2013 May 27 doi: 10.1093/eurheartj/eht187. PMID: 23713082Free PMC Article

Prognosis

Drug-induced Fanconi syndrome in patients with kidney allograft transplantation.
Tang Z, Li T, Dai H, Feng C, Xie X, Peng F, Lan G, Yu S, Wang Y, Fang C, Nie M, Yuan X, Tang X, Jiang X, Zhu X, Fan Y, Peng J, Sun S, Zhong M, Zhang H, Peng L
Front Immunol 2022;13:979983. Epub 2022 Aug 19 doi: 10.3389/fimmu.2022.979983. PMID: 36059468Free PMC Article
Subclinical AKI: ready for primetime in clinical practice?
Vanmassenhove J, Van Biesen W, Vanholder R, Lameire N
J Nephrol 2019 Feb;32(1):9-16. Epub 2018 Dec 6 doi: 10.1007/s40620-018-00566-y. PMID: 30523562
Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.
Ahmad T, Jackson K, Rao VS, Tang WHW, Brisco-Bacik MA, Chen HH, Felker GM, Hernandez AF, O'Connor CM, Sabbisetti VS, Bonventre JV, Wilson FP, Coca SG, Testani JM
Circulation 2018 May 8;137(19):2016-2028. Epub 2018 Jan 19 doi: 10.1161/CIRCULATIONAHA.117.030112. PMID: 29352071Free PMC Article
Chronic Kidney Disease: Detection and Evaluation.
Gaitonde DY, Cook DL, Rivera IM
Am Fam Physician 2017 Dec 15;96(12):776-783. PMID: 29431364
Pseudo-(tumor-induced) rickets.
Whyte MP, Podgornik MN, Wollberg VA, Eddy MC, McAlister WH
J Bone Miner Res 2001 Aug;16(8):1564-71. doi: 10.1359/jbmr.2001.16.8.1564. PMID: 11499880

Clinical prediction guides

Prevalence of Chronic Kidney Disease in China: Results From the Sixth China Chronic Disease and Risk Factor Surveillance.
Wang L, Xu X, Zhang M, Hu C, Zhang X, Li C, Nie S, Huang Z, Zhao Z, Hou FF, Zhou M
JAMA Intern Med 2023 Apr 1;183(4):298-310. doi: 10.1001/jamainternmed.2022.6817. PMID: 36804760Free PMC Article
Association between urine 6-sulfatoxy-melatonin level and intravesical Bacillus Calmette-Guerin treatment-induced sleep quality deterioration in patients with non-muscle invasive bladder cancer.
Miyake M, Nishimura N, Ohnishi S, Oda Y, Miyamoto T, Shimizu T, Hori S, Morizawa Y, Gotoh D, Nakai Y, Anai S, Torimoto K, Aoki K, Fujii T, Tanaka N, Fujimoto K
Support Care Cancer 2022 Jul;30(7):6145-6153. Epub 2022 Apr 14 doi: 10.1007/s00520-022-07043-0. PMID: 35426045
Effect of high-dose intravenous ascorbic acid on cancer patients following ketogenic diet.
Sebastian S, Paul A, Joby J, Saijan S, Vilapurathu JK
J Cancer Res Ther 2021 Oct-Dec;17(6):1583-1586. doi: 10.4103/jcrt.JCRT_973_19. PMID: 34916403
Tubular secretion of creatinine and kidney function: an observational study.
Zhang X, Rule AD, McCulloch CE, Lieske JC, Ku E, Hsu CY
BMC Nephrol 2020 Mar 30;21(1):108. doi: 10.1186/s12882-020-01736-6. PMID: 32228497Free PMC Article
Subclinical AKI: ready for primetime in clinical practice?
Vanmassenhove J, Van Biesen W, Vanholder R, Lameire N
J Nephrol 2019 Feb;32(1):9-16. Epub 2018 Dec 6 doi: 10.1007/s40620-018-00566-y. PMID: 30523562

Recent systematic reviews

Renal Protection and Safety of Sodium-glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease.
Zhou T, Yao K, Xie Y, Lin Y, Wang J, Chen X
Curr Pharm Des 2023;29(21):1659-1670. doi: 10.2174/1381612829666230804103643. PMID: 37537933
The effect of quercetin on diabetic nephropathy (DN): a systematic review and meta-analysis of animal studies.
Hu T, Yue J, Tang Q, Cheng KW, Chen F, Peng M, Zhou Q, Wang M
Food Funct 2022 May 10;13(9):4789-4803. doi: 10.1039/d1fo03958j. PMID: 35416188
The effect of dexmedetomidine on renal function after surgery: A systematic review and meta-analysis.
Loomba RS, Villarreal EG, Dhargalkar J, Rausa J, Dorsey V, Farias JS, Flores S
J Clin Pharm Ther 2022 Mar;47(3):287-297. Epub 2021 Sep 12 doi: 10.1111/jcpt.13527. PMID: 34510502
Effect of Calcium Fortified Foods on Health Outcomes: A Systematic Review and Meta-Analysis.
Cormick G, Betran AP, Romero IB, Cormick MS, Belizán JM, Bardach A, Ciapponi A
Nutrients 2021 Jan 22;13(2) doi: 10.3390/nu13020316. PMID: 33499250Free PMC Article
Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis.
Mitaka C, Kudo T, Haraguchi G, Tomita M
Crit Care 2011;15(5):R258. Epub 2011 Oct 27 doi: 10.1186/cc10519. PMID: 22032777Free PMC Article

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