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Elevated urinary N-methylhistamine level

MedGen UID:
1052405
•Concept ID:
CN377364
•
Finding
HPO: HP:6000533

Definition

The amount of N-methylhistamine in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary N-methylhistamine level

Recent clinical studies

Etiology

Differential mast cell mediators in systemic mastocytosis and hereditary α-tryptasemia.
Giannetti MP, Godwin G, Weller E, Butterfield JH, Castells M
J Allergy Clin Immunol 2022 Nov;150(5):1225-1227. Epub 2022 May 9 doi: 10.1016/j.jaci.2022.04.025. PMID: 35550148
Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet.
Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, Buchwald F, Schultis HW, Kressel J, Hahn EG, Konturek P
BMC Gastroenterol 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4. PMID: 25888445Free PMC Article
Urinary N-methylhistamine as an indicator of bone marrow involvement in mastocytosis.
Oranje AP, Mulder PG, Heide R, Tank B, Riezebos P, van Toorenenbergen AW
Clin Exp Dermatol 2002 Sep;27(6):502-6. doi: 10.1046/j.1365-2230.2002.01072.x. PMID: 12372095

Diagnosis

Differential mast cell mediators in systemic mastocytosis and hereditary α-tryptasemia.
Giannetti MP, Godwin G, Weller E, Butterfield JH, Castells M
J Allergy Clin Immunol 2022 Nov;150(5):1225-1227. Epub 2022 May 9 doi: 10.1016/j.jaci.2022.04.025. PMID: 35550148
Survey of Mast Cell Mediator Levels from Patients Presenting with Symptoms of Mast Cell Activation.
Butterfield JH
Int Arch Allergy Immunol 2020;181(1):43-50. Epub 2019 Nov 13 doi: 10.1159/000503964. PMID: 31722348
Mast Cell Mediators of Significance in Clinical Practice in Mastocytosis.
Butterfield JH, Ravi A, Pongdee T
Immunol Allergy Clin North Am 2018 Aug;38(3):397-410. Epub 2018 Jun 9 doi: 10.1016/j.iac.2018.04.011. PMID: 30007459
Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet.
Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, Buchwald F, Schultis HW, Kressel J, Hahn EG, Konturek P
BMC Gastroenterol 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4. PMID: 25888445Free PMC Article
Urinary N-methylhistamine as an indicator of bone marrow involvement in mastocytosis.
Oranje AP, Mulder PG, Heide R, Tank B, Riezebos P, van Toorenenbergen AW
Clin Exp Dermatol 2002 Sep;27(6):502-6. doi: 10.1046/j.1365-2230.2002.01072.x. PMID: 12372095

Therapy

Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet.
Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, Buchwald F, Schultis HW, Kressel J, Hahn EG, Konturek P
BMC Gastroenterol 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4. PMID: 25888445Free PMC Article
Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production.
Butterfield JH, Weiler CR
Int Arch Allergy Immunol 2008;147(4):338-43. Epub 2008 Jul 12 doi: 10.1159/000144042. PMID: 18622141

Prognosis

Eosinophil degranulation during pregnancy and after delivery by cesarean section.
Matsumoto K, Ogasawara T, Kato A, Homma T, Iida M, Akasawa A, Wakiguchi H, Saito H
Int Arch Allergy Immunol 2003 Jun;131 Suppl 1:34-9. doi: 10.1159/000070479. PMID: 12771547

Clinical prediction guides

Excretion of urinary histamine and N-tele methylhistamine in patients with gastrointestinal food allergy compared to non-allergic controls during an unrestricted diet and a hypoallergenic diet.
Raithel M, Hagel A, Albrecht H, Zopf Y, Naegel A, Baenkler HW, Buchwald F, Schultis HW, Kressel J, Hahn EG, Konturek P
BMC Gastroenterol 2015 Apr 1;15:41. doi: 10.1186/s12876-015-0268-4. PMID: 25888445Free PMC Article
Eosinophil degranulation during pregnancy and after delivery by cesarean section.
Matsumoto K, Ogasawara T, Kato A, Homma T, Iida M, Akasawa A, Wakiguchi H, Saito H
Int Arch Allergy Immunol 2003 Jun;131 Suppl 1:34-9. doi: 10.1159/000070479. PMID: 12771547

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