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GTR Home > Conditions/Phenotypes > Malaria, susceptibility to

Malaria, susceptibility to

Summary

Malaria, a major cause of child mortality worldwide, is caused by mosquito-borne hematoprotozoan parasites of the genus Plasmodium. Of the 4 species that infect humans, P. falciparum causes the most severe forms of malaria and is the major cause of death and disease. Although less fatal, P. malariae, P. ovale, and, in particular, P. vivax infections are major causes of morbidity. The parasite cycle involves a first stage in liver cells and a subsequent stage at erythrocytes, when malaria symptoms occur. A wide spectrum of phenotypes are observed, from asymptomatic infection to mild disease, including fever and mild anemia, to severe disease, including cerebral malaria, profound anemia, and respiratory distress. Genetic factors influence the response to infection, as well as disease progression and severity. Malaria is the strongest known selective pressure in the recent history of the human genome, and it is the evolutionary driving force behind sickle-cell disease (603903), thalassemia (see 141800), glucose-6-phosphatase deficiency (300908), and other erythrocyte defects that together constitute the most common mendelian diseases of humans (Kwiatkowski, 2005; Campino et al., 2006). [from OMIM]

Available tests

92 tests are in the database for this condition.

Clinical tests (92 available)

Molecular Genetics Tests

Genes See tests for all associated and related genes

  • Also known as: CCBP1, CD234, DARC, DARC/ACKR1, Dfy, FY, GPD, GpFy, WBCQ1, ACKR1
    Summary: atypical chemokine receptor 1 (Duffy blood group)

  • Also known as: BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36
    Summary: CD36 molecule (CD36 blood group)

  • Also known as: BACTS2, CIS, CIS-1, G18, SOCS, CISH
    Summary: cytokine inducible SH2 containing protein

  • Also known as: C3BR, C4BR, CD35, KN, CR1
    Summary: complement C3b/C4b receptor 1 (Knops blood group)

  • Also known as: CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, FcgammaRIIa, IGFR2, FCGR2A
    Summary: Fc gamma receptor IIa

  • Also known as: CD32, CD32B, FCG2, FCGR2, FCGR2C, FcGRIIB, FcRII-c, FcgammaRIIb, IGFR2, FCGR2B
    Summary: Fc gamma receptor IIb

  • Also known as: G6PD1, G6PD
    Summary: glucose-6-phosphate dehydrogenase

  • Also known as: CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2, GYPA
    Summary: glycophorin A (MNS blood group)

  • Also known as: CD235b, GPB, GYP, GYPA, MNS, PAS-3, SS, GYPB
    Summary: glycophorin B (MNS blood group)

  • Also known as: CD236, CD236R, GE, GPC, GPD, GYPD, PAS-2, PAS-2', GYPC
    Summary: glycophorin C (Gerbich blood group)

  • Also known as: CD113t-C, ECYT6, beta-globin, HBB
    Summary: hemoglobin subunit beta

  • Also known as: BB2, CD54, P3.58, ICAM1
    Summary: intercellular adhesion molecule 1

  • Also known as: HEP-NOS, INOS, NOS, NOS2A, NOS2
    Summary: nitric oxide synthase 2

  • Also known as: AE1, BND3, CD233, CHC, DI, EMPB3, EPB3, FR, RTA1A, SAO, SPH4, SW, WD, WD1, WR, SLC4A1
    Summary: solute carrier family 4 member 1 (Diego blood group)

  • Also known as: BACTS1, Mal, MyD88-2, wyatt, TIRAP
    Summary: TIR domain containing adaptor protein

  • Also known as: DIF, TNF-alpha, TNFA, TNFSF2, TNLG1F, TNF
    Summary: tumor necrosis factor

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