SRSF9 serine and arginine rich splicing factor 9 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRSF9provided by HGNC
Official Full Name: serine and arginine rich splicing factor 9provided by HGNC
Primary source: HGNC:HGNC:10791
See related: Ensembl:ENSG00000111786 MIM:601943; AllianceGenome:HGNC:10791
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SFRS9; SRp30c
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010]
Expression: Ubiquitous expression in testis (RPKM 59.8), lymph node (RPKM 55.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (120461672..120469748, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (120450186..120458930, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (120899475..120907551, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigation of the effect of SRSF9 overexpression on HIV-1 production.
Title: Investigation of the effect of SRSF9 overexpression on HIV-1 production.
High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis.
Title: High expression of serine and arginine-rich splicing factor 9 (SRSF9) is associated with hepatocellular carcinoma progression and a poor prognosis.
SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner.
Title: SRSF9 promotes colorectal cancer progression via stabilizing DSN1 mRNA in an m6A-related manner.
SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon.
Title: SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon.
AMP-activated protein kinase regulates beta-catenin protein synthesis by phosphorylating serine/arginine-rich splicing factor 9.
Title: AMP-activated protein kinase regulates β-catenin protein synthesis by phosphorylating serine/arginine-rich splicing factor 9.
High SRSF9 expression is associated with cervical cancer.
Title: microRNA-802 inhibits cell proliferation and induces apoptosis in human cervical cancer by targeting serine/arginine-rich splicing factor 9.
LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation.
Title: LncRNA-dependent nuclear stress bodies promote intron retention through SR protein phosphorylation.
Results identified SRSF9 protein as one of the factors involved in modulating the splicing of the DDC mutated (c.714+4A>T) transcript.
Title: Antisense oligonucleotides modulate dopa decarboxylase function in aromatic l-amino acid decarboxylase deficiency.
The splicing factor SRSF9 is a key factor that serves to restrict the editing of numerous protein-coding and non-coding sites to the brain. The results highlight the importance of SRSF9 as an editing regulator and suggest potential roles for other splicing factors.
Title: SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates.
Dehydroepiandrosterone (DHEA) and cortisol modulate SRSF9 and SRSF3 in a different way and data suggest that the anti-glucocorticoid effect of DHEA, among other mechanisms, is also exerted by modulating the expression of proteins involved in the splicing of the GR pre-mRNA.
Title: Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, serine/arginine-rich splicing factor 9 (SRSF9), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with SRSF9 is increased by RRE	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G19881 (e-PCR)
- UniSTS:63784

A002B13 (e-PCR)
- UniSTS:63785

RH44493 (e-PCR)
- UniSTS:32056

RH80576 (e-PCR)
- UniSTS:89678

STS-W73277 (e-PCR)
- UniSTS:16212

Cda16c02 (e-PCR)
- UniSTS:90808

NoName (e-PCR)
- UniSTS:484339

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA processing	TAS Traceable Author Statement more info	PubMed
involved_in mRNA splice site recognition	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in response to alkaloid	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 9

Names: SR splicing factor 9; pre-mRNA-splicing factor SRp30C; splicing factor, arginine/serine-rich 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003769.3 → NP_003760.1 serine/arginine-rich splicing factor 9

See identical proteins and their annotated locations for NP_003760.1

Status: REVIEWED

Source sequence(s)

AI005398, BU786332, U30825

Consensus CDS

CCDS9199.1

UniProtKB/Swiss-Prot

Q13242, Q52LD1

UniProtKB/TrEMBL

A8K3M9

Related

ENSP00000229390.3, ENST00000229390.8

Conserved Domains (2) summary

cd12598
Location:15 → 86

RRM1_SRSF9; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 9 (SRSF9)

cd12768
Location:104 → 186

RRM2_SRSF9; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 9 (SRSF9)