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    SUN1 Sad1 and UNC84 domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 23353, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SUN1provided by HGNC
    Official Full Name
    Sad1 and UNC84 domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18587
    See related
    Ensembl:ENSG00000164828 MIM:607723; AllianceGenome:HGNC:18587
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNC84A
    Summary
    This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]
    Expression
    Ubiquitous expression in endometrium (RPKM 45.0), skin (RPKM 41.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SUN1 in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (815557..874934)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (918630..978053)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (855194..914571)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17818 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:770503-771002 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:791462-792661 Neighboring gene dynein axonemal assembly factor 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:807142-808341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:821444-822643 Neighboring gene uncharacterized LOC124901567 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:837226-837726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:849762-850262 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:850239-850399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:852706-853270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:853271-853834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:855273-856014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17821 Neighboring gene Sharpr-MPRA regulatory region 7003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:869831-870726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25474 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:871666-872865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25475 Neighboring gene uncharacterized LOC124901568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:923699-924455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:925261-925974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:925975-926688 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_100798 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:932665-932864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:938411-938998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:938999-939585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:947339-948037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17826 Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:967671-968257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25481 Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17828 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:984861-986060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:988546-989191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:989192-989836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:992766-993377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17830 Neighboring gene uncharacterized LOC124901569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:994600-995209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans. Meng Q, et al. Hum Genet, 2023 Apr. PMID 36933034
    2. Nuclear restriction of HIV-1 infection by SUN1. Persaud M, et al. Sci Rep, 2021 Sep 27. PMID 34580332, Free PMC Article
    3. The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure. Satomi E, et al. Genes Cells, 2020 Nov. PMID 32931086
    4. Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging. Chang W, et al. Proc Natl Acad Sci U S A, 2019 Feb 26. PMID 30808750, Free PMC Article
    5. SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A. Luo X, et al. J Virol, 2018 Jul 1. PMID 29643244, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
      Title: SUN1 facilitates CHMP7 nuclear influx and injury cascades in sporadic amyotrophic lateral sclerosis.
    2. Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans.
      Title: Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans.
    3. Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans.
      Title: Homozygous missense mutation in CCDC155 disrupts the transmembrane distribution of CCDC155 and SUN1, resulting in non-obstructive azoospermia and premature ovarian insufficiency in humans.
    4. Nuclear restriction of HIV-1 infection by SUN1.
      Title: Nuclear restriction of HIV-1 infection by SUN1.
    5. The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
      Title: The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal.
    6. The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure.
      Title: The SUN1 splicing variants SUN1_888 and SUN1_916 differentially regulate nucleolar structure.
    7. The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
      Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
    8. SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
      Title: SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
    9. Progerin overexpression increased levels of SUN1, which couples the nucleus to microtubules through nesprin-2G and dynein, and microtubule association with the nucleus. Reducing microtubule-nuclear connections through SUN1 depletion or dynein inhibition rescued the polarity defects.
      Title: Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.
    10. Results provide evidence that SUN1 is involved in mRNA export and this function is regulated by phosphorylation of serine 113 in the N-terminal domain.
      Title: The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with Sad1 and UNC84 domain containing 1 (SUN1; UNC84A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: GET4

    Homology

    Clone Names

    • FLJ12407, KIAA0810, MGC176649

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytoskeleton-nuclear membrane anchor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lamin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic attachment of telomere to nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear matrix anchoring at nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    SUN domain-containing protein 1
    Names
    Sad1 unc-84 domain protein 1
    protein unc-84 homolog A
    sad1/unc-84 protein-like 1
    unc-84 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130965.3 → NP_001124437.1  SUN domain-containing protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1, 72, and 73 all encode the same isoform (a).
      Source sequence(s)
      AB018353, AC099731, AK022816, BM689998
      Consensus CDS
      CCDS47525.1
      UniProtKB/Swiss-Prot
      A5PL20, B3KMV7, B4DZF7, B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13, O94901, Q96CZ7, Q9HA14, Q9UH98
      UniProtKB/TrEMBL
      A7MCZ7
      Related
      ENSP00000384015.1, ENST00000401592.6
      Conserved Domains (5) summary
      COG1196
      Location:366 → 560
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:648 → 783
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:62 → 291
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:547 → 605
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21439
      Location:417 → 470
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    2. NM_001171944.2 → NP_001165415.1  SUN domain-containing protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks three in-frame exons in the middle portion of the coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC099731
      Consensus CDS
      CCDS55080.1
      UniProtKB/TrEMBL
      A0A8I5G938, A7MCZ7
      Related
      ENSP00000413439.2, ENST00000452783.6
      Conserved Domains (3) summary
      pfam07738
      Location:545 → 680
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:72 → 189
      MRP; Mitochondrial RNA binding protein MRP
      pfam16043
      Location:336 → 452
      DUF4795; Domain of unknown function (DUF4795)

    3. NM_001171945.2 → NP_001165416.1  SUN domain-containing protein 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate, upstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter than isoform a.
      Source sequence(s)
      AC099731
      Consensus CDS
      CCDS55078.1
      UniProtKB/Swiss-Prot
      O94901
      Related
      ENSP00000395952.2, ENST00000457378.6
      Conserved Domains (1) summary
      pfam09387
      Location:93 → 269
      MRP; Mitochondrial RNA binding protein MRP

    4. NM_001171946.2 → NP_001165417.1  SUN domain-containing protein 1 isoform e

      See identical proteins and their annotated locations for NP_001165417.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC099731
      Consensus CDS
      CCDS55079.1
      UniProtKB/Swiss-Prot
      O94901
      Related
      ENSP00000383947.1, ENST00000403868.5
      Conserved Domains (1) summary
      pfam09387
      Location:72 → 248
      MRP; Mitochondrial RNA binding protein MRP

    5. NM_001367633.1 → NP_001354562.1  SUN domain-containing protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (73), as well as variants 1 and 72, encodes isoform a.
      Source sequence(s)
      AC099731
      Consensus CDS
      CCDS47525.1
      UniProtKB/Swiss-Prot
      A5PL20, B3KMV7, B4DZF7, B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13, O94901, Q96CZ7, Q9HA14, Q9UH98
      UniProtKB/TrEMBL
      A7MCZ7
      Conserved Domains (5) summary
      COG1196
      Location:366 → 560
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:648 → 783
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:62 → 291
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:547 → 605
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21439
      Location:417 → 470
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    6. NM_001367634.1 → NP_001354563.1  SUN domain-containing protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (72), as well as variants 1 and 73, encodes isoform a.
      Source sequence(s)
      AC099731
      Consensus CDS
      CCDS47525.1
      UniProtKB/Swiss-Prot
      A5PL20, B3KMV7, B4DZF7, B7WNY4, B7WP53, E9PDU4, E9PF23, F8WD13, O94901, Q96CZ7, Q9HA14, Q9UH98
      UniProtKB/TrEMBL
      A7MCZ7
      Conserved Domains (5) summary
      COG1196
      Location:366 → 560
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam07738
      Location:648 → 783
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:62 → 291
      MRP; Mitochondrial RNA binding protein MRP
      pfam18580
      Location:547 → 605
      Sun2_CC2; SUN2 coiled coil domain 2
      cd21439
      Location:417 → 470
      SUN1_cc1; coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins

    7. NM_001367635.1 → NP_001354564.1  SUN domain-containing protein 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      H0Y6N5

    8. NM_001367636.1 → NP_001354565.1  SUN domain-containing protein 1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    9. NM_001367637.1 → NP_001354566.1  SUN domain-containing protein 1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC099731

    10. NM_001367638.1 → NP_001354567.1  SUN domain-containing protein 1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    11. NM_001367639.1 → NP_001354568.1  SUN domain-containing protein 1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      H0Y6N5
      Related
      ENSP00000406653.1, ENST00000433212.5

    12. NM_001367640.1 → NP_001354569.1  SUN domain-containing protein 1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    13. NM_001367641.1 → NP_001354570.1  SUN domain-containing protein 1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    14. NM_001367642.1 → NP_001354571.1  SUN domain-containing protein 1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    15. NM_001367643.1 → NP_001354572.1  SUN domain-containing protein 1 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    16. NM_001367644.1 → NP_001354573.1  SUN domain-containing protein 1 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    17. NM_001367645.1 → NP_001354574.1  SUN domain-containing protein 1 isoform p

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    18. NM_001367646.1 → NP_001354575.1  SUN domain-containing protein 1 isoform q

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      H0Y742

    19. NM_001367647.1 → NP_001354576.1  SUN domain-containing protein 1 isoform r

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    20. NM_001367648.1 → NP_001354577.1  SUN domain-containing protein 1 isoform s

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    21. NM_001367649.1 → NP_001354578.1  SUN domain-containing protein 1 isoform t

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    22. NM_001367651.1 → NP_001354580.1  SUN domain-containing protein 1 isoform u

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    23. NM_001367653.1 → NP_001354582.1  SUN domain-containing protein 1 isoform v

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    24. NM_001367655.1 → NP_001354584.1  SUN domain-containing protein 1 isoform w

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    25. NM_001367658.1 → NP_001354587.1  SUN domain-containing protein 1 isoform x

      Status: REVIEWED

      Source sequence(s)
      AC099731

    26. NM_001367660.1 → NP_001354589.1  SUN domain-containing protein 1 isoform y

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    27. NM_001367662.1 → NP_001354591.1  SUN domain-containing protein 1 isoform z

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    28. NM_001367664.1 → NP_001354593.1  SUN domain-containing protein 1 isoform aa

      Status: REVIEWED

      Source sequence(s)
      AC099731
      Consensus CDS
      CCDS94043.1
      UniProtKB/TrEMBL
      A7MCZ7, E9PHI4
      Related
      ENSP00000384116.1, ENST00000405266.5

    29. NM_001367665.1 → NP_001354594.1  SUN domain-containing protein 1 isoform bb

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    30. NM_001367666.1 → NP_001354595.1  SUN domain-containing protein 1 isoform cc

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    31. NM_001367667.1 → NP_001354596.1  SUN domain-containing protein 1 isoform dd

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    32. NM_001367668.1 → NP_001354597.1  SUN domain-containing protein 1 isoform ee

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    33. NM_001367669.1 → NP_001354598.1  SUN domain-containing protein 1 isoform ff

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    34. NM_001367670.1 → NP_001354599.1  SUN domain-containing protein 1 isoform gg

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    35. NM_001367671.1 → NP_001354600.1  SUN domain-containing protein 1 isoform hh

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    36. NM_001367672.1 → NP_001354601.1  SUN domain-containing protein 1 isoform ii

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    37. NM_001367673.1 → NP_001354602.1  SUN domain-containing protein 1 isoform jj

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      H0Y742
      Related
      ENSP00000409909.1, ENST00000429178.5

    38. NM_001367674.1 → NP_001354603.1  SUN domain-containing protein 1 isoform kk

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    39. NM_001367675.1 → NP_001354604.1  SUN domain-containing protein 1 isoform ll

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    40. NM_001367676.1 → NP_001354605.1  SUN domain-containing protein 1 isoform mm

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    41. NM_001367677.1 → NP_001354606.1  SUN domain-containing protein 1 isoform nn

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    42. NM_001367678.1 → NP_001354607.1  SUN domain-containing protein 1 isoform oo

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    43. NM_001367679.1 → NP_001354608.1  SUN domain-containing protein 1 isoform pp

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    44. NM_001367680.1 → NP_001354609.1  SUN domain-containing protein 1 isoform qq

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    45. NM_001367681.1 → NP_001354610.1  SUN domain-containing protein 1 isoform rr

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    46. NM_001367682.1 → NP_001354611.1  SUN domain-containing protein 1 isoform ss

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    47. NM_001367683.1 → NP_001354612.1  SUN domain-containing protein 1 isoform tt

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    48. NM_001367684.1 → NP_001354613.1  SUN domain-containing protein 1 isoform uu

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    49. NM_001367685.1 → NP_001354614.1  SUN domain-containing protein 1 isoform vv

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    50. NM_001367686.1 → NP_001354615.1  SUN domain-containing protein 1 isoform ww

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    51. NM_001367687.1 → NP_001354616.1  SUN domain-containing protein 1 isoform xx

      Status: REVIEWED

      Source sequence(s)
      AC099731

    52. NM_001367688.1 → NP_001354617.1  SUN domain-containing protein 1 isoform yy

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    53. NM_001367689.1 → NP_001354618.1  SUN domain-containing protein 1 isoform zz

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    54. NM_001367690.1 → NP_001354619.1  SUN domain-containing protein 1 isoform aaa

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    55. NM_001367691.1 → NP_001354620.1  SUN domain-containing protein 1 isoform bbb

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    56. NM_001367692.1 → NP_001354621.1  SUN domain-containing protein 1 isoform ccc

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A0A146IHP0, A7MCZ7

    57. NM_001367693.1 → NP_001354622.1  SUN domain-containing protein 1 isoform ddd

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    58. NM_001367694.1 → NP_001354623.1  SUN domain-containing protein 1 isoform eee

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    59. NM_001367695.1 → NP_001354624.1  SUN domain-containing protein 1 isoform fff

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    60. NM_001367696.1 → NP_001354625.1  SUN domain-containing protein 1 isoform ggg

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    61. NM_001367697.1 → NP_001354626.1  SUN domain-containing protein 1 isoform hhh

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    62. NM_001367698.1 → NP_001354627.1  SUN domain-containing protein 1 isoform iii

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    63. NM_001367699.1 → NP_001354628.1  SUN domain-containing protein 1 isoform jjj

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    64. NM_001367700.1 → NP_001354629.1  SUN domain-containing protein 1 isoform kkk

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    65. NM_001367701.1 → NP_001354630.1  SUN domain-containing protein 1 isoform lll

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    66. NM_001367702.1 → NP_001354631.1  SUN domain-containing protein 1 isoform mmm

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    67. NM_001367703.1 → NP_001354632.1  SUN domain-containing protein 1 isoform nnn

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    68. NM_001367704.1 → NP_001354633.1  SUN domain-containing protein 1 isoform ooo

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A7MCZ7

    69. NM_001367705.1 → NP_001354634.1  SUN domain-containing protein 1 isoform ppp

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0
      Related
      ENST00000413171.6

    70. NM_001367706.1 → NP_001354635.1  SUN domain-containing protein 1 isoform qqq

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      A4D2Q0

    71. NM_001367708.1 → NP_001354637.1  SUN domain-containing protein 1 isoform sss

      Status: REVIEWED

      Source sequence(s)
      AC099731
      UniProtKB/TrEMBL
      H0Y6N5

    72. NM_025154.6 → NP_079430.3  SUN domain-containing protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon in the 5' portion of the coding region. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC099731
      Consensus CDS
      CCDS43533.1
      UniProtKB/TrEMBL
      A7MCZ7
      Related
      ENSP00000374225.3, ENST00000389574.7
      Conserved Domains (3) summary
      pfam07738
      Location:565 → 700
      Sad1_UNC; Sad1 / UNC-like C-terminal
      pfam09387
      Location:22 → 208
      MRP; Mitochondrial RNA binding protein MRP
      pfam16043
      Location:356 → 472
      DUF4795; Domain of unknown function (DUF4795)

    RNA

    1. NR_160281.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC099731

    2. NR_160282.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC099731

    3. NR_160283.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC099731

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      815557..874934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      918630..978053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94901.4 GenPept UniProtKB/Swiss-Prot:O94901

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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