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    Spdye4a speedy/RINGO cell cycle regulator family, member E4A [ Mus musculus (house mouse) ]

    Gene ID: 74673, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Spdye4aprovided by MGI
    Official Full Name
    speedy/RINGO cell cycle regulator family, member E4Aprovided by MGI
    Primary source
    MGI:MGI:1921923
    See related
    Ensembl:ENSMUSG00000039296 AllianceGenome:MGI:1921923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spdy2; Spdyb; Spdye4; RINGO E4A; Spy/Ringo B; 4930445A17Rik; 4930451F05Rik
    Summary
    Enables protein kinase binding activity. Involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be located in nucleus. Is expressed in testis. Orthologous to several human genes including SPDYE4 (speedy/RINGO cell cycle regulator family member E4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 5.6) See more
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    Genomic context

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    See Spdye4a in Genome Data Viewer
    Location:
    5 G2; 5 82.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143202070..143212657, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143216315..143226902, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RB-associated KRAB zinc finger Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143942516-143942699 Neighboring gene speedy/RINGO cell cycle regulator family, member E4B Neighboring gene RIKEN cDNA 4930448H16 gene Neighboring gene predicted gene, 38735 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:143996641-143996853 Neighboring gene zinc finger protein 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene. Xu H, et al. Gen Comp Endocrinol, 2023 Jan 1. PMID 36272447
    2. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cheng A, et al. Cell Cycle, 2005 Jan. PMID 15611625
    3. Characterization of a new family of cyclin-dependent kinase activators. Dinarina A, et al. Biochem J, 2005 Mar 1. PMID 15574121, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.
      Title: Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    speedy protein E4A
    Names
    mSpy/Ringo B
    mSpy/Ringo E4A
    rapid inducer of G2/M progression in oocytes B
    rapid inducer of G2/M progression in oocytes E4A
    speedy homolog 2
    speedy homolog E4
    speedy protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310757.1 → NP_001297686.1  speedy protein E4A isoform 2

      See identical proteins and their annotated locations for NP_001297686.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AC123686, AK015385, AK015441
      Consensus CDS
      CCDS80456.1
      UniProtKB/TrEMBL
      B9EIX3
      Related
      ENSMUSP00000123959.2, ENSMUST00000160502.2
      Conserved Domains (1) summary
      pfam11357
      Location:98 → 156
      Spy1; Cell cycle regulatory protein

    2. NM_029048.3 → NP_083324.3  speedy protein E4A isoform 1

      See identical proteins and their annotated locations for NP_083324.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123686, AK015441
      Consensus CDS
      CCDS39368.1
      UniProtKB/Swiss-Prot
      Q5IBH6
      Related
      ENSMUSP00000082882.3, ENSMUST00000085733.9
      Conserved Domains (1) summary
      pfam11357
      Location:135 → 264
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143202070..143212657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504749.3 → XP_006504812.1  speedy protein E4A isoform X1

      UniProtKB/TrEMBL
      A0A0G2JEI8
      Related
      ENSMUSP00000142788.2, ENSMUST00000195900.5
      Conserved Domains (1) summary
      pfam11357
      Location:101 → 227
      Spy1; Cell cycle regulatory protein

    2. XM_011240987.4 → XP_011239289.1  speedy protein E4A isoform X2

      Conserved Domains (1) summary
      pfam11357
      Location:138 → 193
      Spy1; Cell cycle regulatory protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IBH6.1 GenPept UniProtKB/Swiss-Prot:Q5IBH6

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