ARHGDIG Rho GDP dissociation inhibitor gamma [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARHGDIGprovided by HGNC
Official Full Name: Rho GDP dissociation inhibitor gammaprovided by HGNC
Primary source: HGNC:HGNC:680
See related: Ensembl:ENSG00000242173 MIM:602844; AllianceGenome:HGNC:680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RHOGDI-3
Summary: The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]
Expression: Biased expression in brain (RPKM 34.7), duodenum (RPKM 7.8) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (280591..283010)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (275429..277879)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (330591..333010)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.
Title: RhoGDI3 at the trans-Golgi network participates in NLRP3 inflammasome activation, VSMC phenotypic modulation, and neointima formation.
These results suggest that the levels of RhoG and RhoB GTPases and their negative regulator RhoGDI3 might be linked to the aggressiveness of the pancreatic cancerous cell lines. It is possible that RhoGDI3 could induce the downregulation of RhoG and RhoB.
Title: Immunological and Functional Characterization of RhoGDI3 and Its Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and Normal Cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.
analysis of inhibitory and shuttling functions of rhoGDI-3 and rhoGDI-1
Title: Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD02068 (e-PCR)
- UniSTS:283169

REN95338 (e-PCR)
- UniSTS:420136

REN95339 (e-PCR)
- UniSTS:420137

REN95340 (e-PCR)
- UniSTS:420138

REN95341 (e-PCR)
- UniSTS:420139

REN95343 (e-PCR)
- UniSTS:420141

REN95344 (e-PCR)
- UniSTS:420142

REN95345 (e-PCR)
- UniSTS:420143

REN95346 (e-PCR)
- UniSTS:420144

REN95347 (e-PCR)
- UniSTS:420145

REN95348 (e-PCR)
- UniSTS:420146

REN95349 (e-PCR)
- UniSTS:420147

REN95350 (e-PCR)
- UniSTS:420148

REN95353 (e-PCR)
- UniSTS:420151

REN95354 (e-PCR)
- UniSTS:420152

REN95356 (e-PCR)
- UniSTS:420154

REN95358 (e-PCR)
- UniSTS:420156

REN95360 (e-PCR)
- UniSTS:420158

REN95361 (e-PCR)
- UniSTS:420159

REN95362 (e-PCR)
- UniSTS:420160

REN95363 (e-PCR)
- UniSTS:420161

REN95364 (e-PCR)
- UniSTS:420162

REN95365 (e-PCR)
- UniSTS:420163

REN95366 (e-PCR)
- UniSTS:420164

REN95367 (e-PCR)
- UniSTS:420165

REN95368 (e-PCR)
- UniSTS:420166

REN95369 (e-PCR)
- UniSTS:420167

ECD11643 (e-PCR)
- UniSTS:292679

REN95370 (e-PCR)
- UniSTS:420168

REN95371 (e-PCR)
- UniSTS:420169

REN95374 (e-PCR)
- UniSTS:420172

REN95375 (e-PCR)
- UniSTS:420173

REN95376 (e-PCR)
- UniSTS:420174

REN95377 (e-PCR)
- UniSTS:420175

REN95378 (e-PCR)
- UniSTS:420176

REN95379 (e-PCR)
- UniSTS:420177

REN95380 (e-PCR)
- UniSTS:420178

REN95382 (e-PCR)
- UniSTS:420180

ECD11673 (e-PCR)
- UniSTS:292709

ECD05777 (e-PCR)
- UniSTS:286839

ECD11496 (e-PCR)
- UniSTS:292532

ECD22570 (e-PCR)
- UniSTS:303556

RH71265 (e-PCR)
- UniSTS:7118

ECD08202 (e-PCR)
- UniSTS:289250

ECD01233 (e-PCR)
- UniSTS:282340

ECD07716 (e-PCR)
- UniSTS:288766

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables Rho GDP-dissociation inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in blastocyst hatching	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	TAS Traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: rho GDP-dissociation inhibitor 3

Names: Rho GDP dissociation inhibitor (GDI) gamma; RhoGDI gamma; rho GDI 3; rho-GDI gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.