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    Sntg1 syntrophin, gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 71096, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sntg1provided by MGI
    Official Full Name
    syntrophin, gamma 1provided by MGI
    Primary source
    MGI:MGI:1918346
    See related
    Ensembl:ENSMUSG00000025909 AllianceGenome:MGI:1918346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SYN4; G1SYN; 4933426D16Rik
    Summary
    Predicted to enable protein C-terminus binding activity. Predicted to be located in cytoplasm; cytoskeleton; and ruffle membrane. Predicted to be part of dystrophin-associated glycoprotein complex. Orthologous to human SNTG1 (syntrophin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sntg1 in Genome Data Viewer
    Location:
    1 A1- A2; 1 2.08 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (8429963..9371882, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (8359739..9301657, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00135 Neighboring gene F-box protein 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00138 Neighboring gene predicted gene, 39589 Neighboring gene STARR-seq mESC enhancer starr_00139 Neighboring gene STARR-seq mESC enhancer starr_00140 Neighboring gene STARR-seq mESC enhancer starr_00143 Neighboring gene STARR-seq mESC enhancer starr_00144 Neighboring gene STARR-seq mESC enhancer starr_00146 Neighboring gene STARR-seq mESC enhancer starr_00148 Neighboring gene STARR-seq mESC enhancer starr_00149 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00150 Neighboring gene STARR-seq mESC enhancer starr_00151 Neighboring gene STARR-seq mESC enhancer starr_00153 Neighboring gene STARR-seq mESC enhancer starr_00156 Neighboring gene STARR-seq mESC enhancer starr_00154 Neighboring gene RING-box protein 2 pseudogene Neighboring gene RING-box protein 2 pseudogene Neighboring gene mitochondrial import inner membrane translocase subunit Tim23 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00157 Neighboring gene STARR-seq mESC enhancer starr_00158 Neighboring gene STARR-seq mESC enhancer starr_00159 Neighboring gene STARR-seq mESC enhancer starr_00160 Neighboring gene predicted gene, 30719 Neighboring gene predicted gene 6187

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins. Alessi A, et al. Exp Cell Res, 2006 Oct 1. PMID 16857187
    2. Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome. Lyssand JS, et al. J Biol Chem, 2008 Jul 4. PMID 18468998, Free PMC Article
    3. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dystrophin-associated glycoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-1-syntrophin
    Names
    syntrophin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290390.1 → NP_001277319.1  gamma-1-syntrophin isoform 2

      See identical proteins and their annotated locations for NP_001277319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC102786, AK038698, AK083241, CJ254355
      Consensus CDS
      CCDS69860.1
      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      UniProtKB/TrEMBL
      Q8C415
      Related
      ENSMUSP00000141839.2, ENSMUST00000191683.6
      Conserved Domains (2) summary
      smart00233
      Location:283 → 388
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 135
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. NM_001290392.1 → NP_001277321.1  gamma-1-syntrophin isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to isoform 1. The encoded protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC102786, AK038698, AK083241, CJ254355
      UniProtKB/TrEMBL
      Q8CAI8
      Conserved Domains (1) summary
      smart00233
      Location:32 → 137
      PH; Pleckstrin homology domain

    3. NM_001290393.1 → NP_001277322.1  gamma-1-syntrophin isoform 1

      See identical proteins and their annotated locations for NP_001277322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC102786, AF367759, AK038698, AK080034, AK083241, CJ254355
      Consensus CDS
      CCDS35509.1
      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      UniProtKB/TrEMBL
      E9Q0U6, Q8BNW6
      Conserved Domains (2) summary
      smart00233
      Location:284 → 389
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    4. NM_027671.5 → NP_081947.2  gamma-1-syntrophin isoform 1

      See identical proteins and their annotated locations for NP_081947.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same protein.
      Source sequence(s)
      AC102786, AK038698, AK080034, AK083241, CJ254355
      Consensus CDS
      CCDS35509.1
      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      UniProtKB/TrEMBL
      E9Q0U6, Q8BNW6
      Related
      ENSMUSP00000118101.3, ENSMUST00000140295.8
      Conserved Domains (2) summary
      smart00233
      Location:284 → 389
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      8429963..9371882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153661.1 → XP_036009554.1  gamma-1-syntrophin isoform X5

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      Conserved Domains (2) summary
      smart00233
      Location:236 → 341
      PH; Pleckstrin homology domain
      cd00992
      Location:7 → 88
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. XM_036153666.1 → XP_036009559.1  gamma-1-syntrophin isoform X7

      UniProtKB/TrEMBL
      Q8CAI8
      Conserved Domains (1) summary
      smart00233
      Location:32 → 137
      PH; Pleckstrin homology domain

    3. XM_036153660.1 → XP_036009553.1  gamma-1-syntrophin isoform X4

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      Conserved Domains (2) summary
      smart00233
      Location:270 → 375
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 135
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    4. XM_017312321.2 → XP_017167810.1  gamma-1-syntrophin isoform X2

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      UniProtKB/TrEMBL
      Q8C415
      Related
      ENSMUSP00000122134.2, ENSMUST00000132064.8
      Conserved Domains (2) summary
      smart00233
      Location:283 → 388
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 135
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    5. XM_006495572.3 → XP_006495635.1  gamma-1-syntrophin isoform X3

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      Conserved Domains (2) summary
      smart00233
      Location:271 → 376
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    6. XM_036153664.1 → XP_036009557.1  gamma-1-syntrophin isoform X7

      UniProtKB/TrEMBL
      Q8CAI8
      Conserved Domains (1) summary
      smart00233
      Location:32 → 137
      PH; Pleckstrin homology domain

    7. XM_036153658.1 → XP_036009551.1  gamma-1-syntrophin isoform X2

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      UniProtKB/TrEMBL
      Q8C415
      Conserved Domains (2) summary
      smart00233
      Location:283 → 388
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 135
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    8. XM_011238407.3 → XP_011236709.1  gamma-1-syntrophin isoform X1

      See identical proteins and their annotated locations for XP_011236709.1

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      UniProtKB/TrEMBL
      E9Q0U6, Q8BNW6
      Conserved Domains (2) summary
      smart00233
      Location:284 → 389
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    9. XM_036153662.1 → XP_036009555.1  gamma-1-syntrophin isoform X5

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      Conserved Domains (2) summary
      smart00233
      Location:236 → 341
      PH; Pleckstrin homology domain
      cd00992
      Location:7 → 88
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    10. XM_017312320.3 → XP_017167809.1  gamma-1-syntrophin isoform X1

      UniProtKB/Swiss-Prot
      Q925E1, Q9D3Z5
      UniProtKB/TrEMBL
      E9Q0U6, Q8BNW6
      Related
      ENSMUSP00000111151.3, ENSMUST00000115488.3
      Conserved Domains (2) summary
      smart00233
      Location:284 → 389
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    11. XM_036153663.1 → XP_036009556.1  gamma-1-syntrophin isoform X6

      Conserved Domains (2) summary
      smart00233
      Location:191 → 264
      PH; Pleckstrin homology domain
      cd00992
      Location:55 → 136
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RNA

    1. XR_001778003.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925E1.2 GenPept UniProtKB/Swiss-Prot:Q925E1

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