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    Mnt max binding protein [ Mus musculus (house mouse) ]

    Gene ID: 17428, updated on 12-May-2024

    Summary

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    Official Symbol
    Mntprovided by MGI
    Official Full Name
    max binding proteinprovided by MGI
    Primary source
    MGI:MGI:109150
    See related
    Ensembl:ENSMUSG00000000282 AllianceGenome:MGI:109150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rox; bHLHd3
    Summary
    Enables DNA binding activity; DNA-binding transcription factor activity; and chromatin binding activity. Acts upstream of or within several processes, including cell aging; negative regulation of apoptotic signaling pathway; and regulation of transcription, DNA-templated. Predicted to be located in nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; future brain; genitourinary system; and retina nuclear layer. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.8), adrenal adult (RPKM 10.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mnt in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74721651..74736551)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74830806..74845725)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40198 Neighboring gene STARR-seq mESC enhancer starr_29970 Neighboring gene STARR-seq mESC enhancer starr_29971 Neighboring gene STARR-positive B cell enhancer ABC_E3000 Neighboring gene methyltransferase 16, N6-methyladenosine Neighboring gene predicted gene, 57584 Neighboring gene STARR-positive B cell enhancer ABC_E8879 Neighboring gene STARR-positive B cell enhancer ABC_E11484 Neighboring gene STARR-positive B cell enhancer ABC_E7015 Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926 Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene TSR1 20S rRNA accumulation Neighboring gene serine racemase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Toyo-oka K, et al. Cancer Res, 2006 Jun 1. PMID 16740691
    2. Inflammatory disease and lymphomagenesis caused by deletion of the Myc antagonist Mnt in T cells. Dezfouli S, et al. Mol Cell Biol, 2006 Mar. PMID 16507988, Free PMC Article
    3. Evidence of mnt-myc antagonism revealed by mnt gene deletion. Hurlin PJ, et al. Cell Cycle, 2004 Feb. PMID 14712062
    4. Mnt-Max to Myc-Max complex switching regulates cell cycle entry. Walker W, et al. J Cell Biol, 2005 May 9. PMID 15866886, Free PMC Article
    5. Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation. Nilsson JA, et al. Mol Cell Biol, 2004 Feb. PMID 14749372, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
      Title: MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis.
    2. Although mnt heterozygosity clearly slowed lymphomagenesis in vavP-MYC10 and Emu-myc mice, the change(s) in cellular properties responsible for this effect remain to be identified.
      Title: Mnt modulates Myc-driven lymphomagenesis.
    3. results redefine the physiological relationship between Mnt and Myc and requirements for Myc-driven oncogenesis
      Title: A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.
    4. Mxd4 and Mnt upregulation following OX40 engagement most likely increases T-cell survival
      Title: OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.
    5. The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis.
      Title: Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes.
    6. Mnt represses Myc target genes and Myc functions as an oncogene by relieving Mnt-mediated repression
      Title: Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation.
    7. There is a unique negative regulatory role for Mnt in governing key Myc functions associated with cell proliferation and tumorigenesis.
      Title: Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis.
    8. Loss of protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects.
      Title: Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome.
    9. Mnt may serve a general role as a Myc antagonist.[Review]
      Title: Evidence of mnt-myc antagonism revealed by mnt gene deletion.
    10. These results demonstrate that Mnt-Myc antagonism plays a fundamental role in regulating cell cycle entry and proliferation.
      Title: Mnt-Max to Myc-Max complex switching regulates cell cycle entry.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    max-binding protein MNT
    Names
    myc antagonist MNT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010813.3 → NP_034943.3  max-binding protein MNT

      See identical proteins and their annotated locations for NP_034943.3

      Status: VALIDATED

      Source sequence(s)
      AW491765, BC054534, CA327080
      Consensus CDS
      CCDS25037.1
      UniProtKB/Swiss-Prot
      O08789, P97349, Q6GTJ3
      UniProtKB/TrEMBL
      Q3UGG9
      Related
      ENSMUSP00000000291.3, ENSMUST00000000291.9
      Conserved Domains (1) summary
      cd11402
      Location:222 → 298
      bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      74721651..74736551
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532402.5 → XP_006532465.1  max-binding protein MNT isoform X1

      UniProtKB/TrEMBL
      Q3UGG9
      Conserved Domains (2) summary
      pfam10944
      Location:267 → 325
      DUF2630; Protein of unknown function (DUF2630)
      cd11402
      Location:221 → 284
      bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

    2. XM_006532403.4 → XP_006532466.1  max-binding protein MNT isoform X2

    3. XM_036156377.1 → XP_036012270.1  max-binding protein MNT isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08789.2 GenPept UniProtKB/Swiss-Prot:O08789

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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