Thor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Thorprovided by FlyBase
Primary source: FLYBASE:FBgn0261560
Locus tag: Dmel_CG8846
See related: AllianceGenome:FB:FBgn0261560
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 153432_at; 43-BP; 4e-bp; 4e-BP; 4E-BP; 4E-BP1; 4ebp; 4eBP; 4EBP; anon-WO0172774.158; BcDNA.HL08053; BcDNA:HL08053; CG8846; CT8705; d4e-bp; d4E-BP; d4E-BP1; d4eBP; d4EBP; Dm 4E-BP; Dmel\CG8846; dthor; eIF4E-BP; l(2)06270; l(2)k07736; l(2)k13517; p4EBP; Phas1; pp20; thor; Thor/EIF4EBP
Summary: Enables eukaryotic initiation factor 4E binding activity. Involved in several processes, including negative regulation of cell size; regulation of translation; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in cytosol. Is expressed in several structures, including digestive system; ectoderm anlage; extended germ band embryo; germ layer; and gonad. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1); EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2); and EIF4EBP3 (eukaryotic translation initiation factor 4E binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 23F3-23F3; 2-10 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3478434..3479612)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3478434..3479612)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dietary Adaptation of Microbiota in Drosophila Requires NF-kappaB-Dependent Control of the Translational Regulator 4E-BP.
Title: Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP.
The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
Title: The S6k/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila.
4E-BP determines lifespan in the context of temperature changes, revealing a genetic mechanism for cold-induced longevity in this model organism. Our results suggest that the 4E-BP pathway, chiefly thought of as a nutrient sensor, may represent a master metabolic switch responding to diverse environmental factors
Title: The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan.
Here, the authors show that cell autonomous insulin signaling within the Drosophila CM9 motor neuron regulates the release of neurotransmitter via alteration of the synaptic vesicle fusion machinery. This effect of insulin utilizes the FOXO-dependent regulation of the thor gene, which encodes the Drosophila homologue of the eif-4e binding protein (4eBP).
Title: Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery.
GCN2 and ATF4 are important regulators of 4E-BP transcription during normal drosophila development and aging.
Title: 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.
longevity assurance mutants of chico, the Drosophila insulin receptor substrate homolog, require Drosophila d4eBP to slow aging.
Title: Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP.
These results indicate that the Ccr4-Not complex controls expression of 4E-BP at multiple levels and adjusts the magnitude of the total effect.
Title: Multi-functional regulation of 4E-BP gene expression by the Ccr4-Not complex.
eIF4E-binding protein requires non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
Title: 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation.
PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression
Title: Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.
These findings reveal an organism-wide regulation of proteostasis in response to muscle aging and a key role of FOXO/4E-BP signaling in the coordination of organismal and tissue aging.
Title: FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables eukaryotic initiation factor 4E binding	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic initiation factor 4E binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic initiation factor 4E binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic initiation factor 4E binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of eukaryotic translation initiation factor 4F complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translational initiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial translation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation at presynapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation at presynapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: thor

Names: 4E binding protein; CG8846-PA; CG8846-PB; Eif4e-binding protein; Thor-PA; Thor-PB; eIF-4E-binding protein; eIF4E binding protein; eif-4e binding protein; eif4e-binding protein 4EBP; eukaryotic initiation factor 4E binding protein; eukaryotic initiation factor 4E- binding protein; eukaryotic initiation factor 4E-binding protein; eukaryotic translation initiation factor 4E binding protein; eukaryotic translation initiation factor 4E-binding protein; insulin-stimulated eIF-4E binding protein; lethal (2) 06270; translation initiation factor 4E binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

3478434..3479612

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057947.4 → NP_477295.1 thor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477295.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XZ56

Related

FBpp0077213

Conserved Domains (1) summary

pfam05456
Location:3 → 117

eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)
NM_001298659.1 → NP_001285588.1 thor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285588.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XZ56

Conserved Domains (1) summary

pfam05456
Location:3 → 117

eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)