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    Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 74203, updated on 9-May-2024

    Summary

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    Official Symbol
    Eif4enif1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4E nuclear import factor 1provided by MGI
    Primary source
    MGI:MGI:1921453
    See related
    Ensembl:ENSMUSG00000020454 AllianceGenome:MGI:1921453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clast4; D11Ertd166e; 2610509L04Rik; A930019J01Rik
    Summary
    Enables mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of translation; and stem cell population maintenance. Located in P-body; cytosol; and nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; epithelium; metanephros; and ovary. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.2), CNS E11.5 (RPKM 15.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif4enif1 in Genome Data Viewer
    Location:
    11 A1; 11 2.24 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3152344..3194588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3202343..3244588)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene elongation factor 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6943 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene predicted gene, 51877 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool. Kolaj A, et al. Cell Rep, 2023 Mar 28. PMID 36924490
    2. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. Martínez A, et al. PLoS One, 2015. PMID 25923732, Free PMC Article
    3. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. Villaescusa JC, et al. Gene, 2006 Feb 15. PMID 16343815
    4. Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. Park CS, et al. BMC Genomics, 2013 Aug 8. PMID 23927422, Free PMC Article
    5. A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. Amadei G, et al. J Neurosci, 2015 Nov 25. PMID 26609159, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.
      Title: Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4E transporter
    Names
    4E-T
    CD40 ligand-activated specific transcript 4
    eIF4E transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166547.1 → NP_001160019.1  eukaryotic translation initiation factor 4E transporter isoform a

      See identical proteins and their annotated locations for NP_001160019.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AK165678, BC033410
      Consensus CDS
      CCDS24354.1
      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000136768.2, ENSMUST00000179770.8
      Conserved Domains (2) summary
      pfam03154
      Location:707 → 934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    2. NM_001166548.1 → NP_001160020.1  eukaryotic translation initiation factor 4E transporter isoform b

      See identical proteins and their annotated locations for NP_001160020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK041598, BC033410, CJ072393
      Consensus CDS
      CCDS48739.1
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000020734.5, ENSMUST00000020734.11
      Conserved Domains (2) summary
      pfam03154
      Location:683 → 910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    3. NM_001166549.1 → NP_001160021.1  eukaryotic translation initiation factor 4E transporter isoform b

      See identical proteins and their annotated locations for NP_001160021.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC033410, BY068596
      Consensus CDS
      CCDS48739.1
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000105675.2, ENSMUST00000110048.8
      Conserved Domains (2) summary
      pfam03154
      Location:683 → 910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    4. NM_023743.2 → NP_076232.2  eukaryotic translation initiation factor 4E transporter isoform a

      See identical proteins and their annotated locations for NP_076232.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
      Source sequence(s)
      AL671968, BC033410
      Consensus CDS
      CCDS24354.1
      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Related
      ENSMUSP00000105676.2, ENSMUST00000110049.8
      Conserved Domains (2) summary
      pfam03154
      Location:707 → 934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      3152344..3194588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514842.5 → XP_006514905.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514905.1

      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:707 → 934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    2. XM_006514844.4 → XP_006514907.1  eukaryotic translation initiation factor 4E transporter isoform X2

      See identical proteins and their annotated locations for XP_006514907.1

      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:683 → 910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    3. XM_006514841.4 → XP_006514904.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514904.1

      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:707 → 934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    4. XM_017314806.3 → XP_017170295.1  eukaryotic translation initiation factor 4E transporter isoform X2

      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:683 → 910
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 686
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

    5. XM_006514843.5 → XP_006514906.1  eukaryotic translation initiation factor 4E transporter isoform X1

      See identical proteins and their annotated locations for XP_006514906.1

      UniProtKB/Swiss-Prot
      Q8CFW0, Q9CSS3, Q9EST3
      UniProtKB/TrEMBL
      Q8BY82
      Conserved Domains (2) summary
      pfam03154
      Location:707 → 934
      Atrophin-1; Atrophin-1 family
      pfam10477
      Location:29 → 710
      EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EST3.2 GenPept UniProtKB/Swiss-Prot:Q9EST3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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